Aromasten 25 (Exemestane 25mg) Tablets: Verified Pharmaceutical Exporter from India | Bulk Supplier for USA, UK, Australia, Thailand, Singapore & Jamaica

Product Profile: Aromasten 25 (Exemestane 25mg Tablets)

Aromasten 25 contains Exemestane, a potent, irreversible steroidal aromatase inactivator. Unlike non-steroidal aromatase inhibitors, Exemestane acts as a “suicide inhibitor,“ permanently binding to the aromatase enzyme and rendering it inactive, which results in a profound reduction of circulating estrogen levels in postmenopausal women.

1. Clinical Indications & Usage

Breast Cancer Treatment: Indicated for the adjuvant treatment of postmenopausal women with estrogen receptor-positive early breast cancer who have received 2–3 years of tamoxifen therapy and are switched to exemestane to complete a total of 5 consecutive years of adjuvant hormonal therapy.

Advanced Breast Cancer: Used for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following anti-estrogen (e.g., tamoxifen) therapy.

2. Mechanism of Action

Irreversible Inhibition: Exemestane structurally mimics the substrate androstenedione. It binds to the active site of the aromatase enzyme, causing its permanent inactivation.

Estrogen Depletion: Because the enzyme is permanently disabled, the body's peripheral conversion of androgens to estrogens is significantly blocked. In postmenopausal women, this is the primary source of estrogen, and its depletion effectively halts the growth of hormone-dependent breast cancer cells.

3. Administration and Dosing

Regimen: The recommended dosage is 25mg taken orally once daily, preferably administered after a meal to enhance absorption.

Consistency: It should be taken at the same time each day to maintain steady-state serum concentrations. Tablets must be swallowed whole.

⚠️ Safety, Side Effects, and Monitoring

Contraindications: Not indicated for premenopausal women. Do not use in patients who are pregnant or breastfeeding. It should not be administered concurrently with estrogen-containing medications (e.g., HRT), as these will negate the drug’s efficacy.

Important Considerations:

Bone Health: By suppressing estrogen, Exemestane can accelerate bone loss, leading to a higher risk of osteoporosis and fractures. Bone mineral density (BMD) monitoring is standard clinical practice.

Lipid Profile: May lead to increases in serum cholesterol and triglyceride levels.

Common Side Effects: Hot flashes, fatigue, joint and muscle pain (arthralgia), nausea, increased sweating, insomnia, and headache.

📦 Storage, Stability & Commercial Packaging

Storage: Store at controlled room temperature (20°C to 25°C / 68°F to 77°F).

Protection: Keep in original blister packaging to protect from moisture and light.

Security: Keep securely out of reach of children.

PRESCRIPTION MEDICINE IS: YES.

Disclaimer: This profile is compiled strictly for international wholesale procurement and commercial educational research. Aromasten 25 is a highly specialized prescription medication and must be utilized strictly under the supervision of a licensed oncologist or physician. All cross-border importing setups must comply with the native health authorities of the destination country.

📞 Contact Ernest Impex — Pharmaceutical Exporter from India

[GROUP OF ERNEST PHARMACEUTICAL PVT. LTD.]

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