INTRODUCTION ABALAM 600/300 is a combination of Abacavir and Lamivudine which belongs to the group of medicines called Anti-viral agents. It is used in the management of HIV infection in adults, adolescents and in children (weighing above 25 kgs). HIV (human immunodeficiency virus) infection is a viral infection that damages our immune system and weakens our body’s ability to fight against various infections. Both abacavir and lamivudine are nucleoside reverse transcriptase inhibitors. They work by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. This prevents further multiplication of viral cells within the body. Also, they can improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. ABALAM 600/300 cannot not manage HIV infection completely. It can reduce only the number of viral cells present in the body and maintains them at a lower level. During management with ABALAM 600/300 your doctor will closely monitor your body weight, blood cholesterol levels and blood sugar levels to reduce the risk of unwanted side effects. Do not take ABALAM 600/300 if you are allergic to abacavir or lamivudine. Before taking ABALAM 600/300 inform your doctor if you have diabetes or any liver (hepatitis C or B infection), kidney or heart problems. If you are already taking ABALAM 600/300 to manage hepatitis B or C infection, do not stop taking it without consulting your doctor. Even if you take ABALAM 600/300, it is important for you to follow certain measures to prevent the spread of infections to the other people (such as avoid having unprotected sexual intercourse or sharing needles or personal items like toothbrush, razors etc with other people). ABALAM 600/300 is not recommended for use in pregnant or breastfeeding women. The most common side effects of taking ABALAM 600/300 are difficulty in sleeping, increased signs of infections, nausea, stomach pain, headache, or dizziness. Consult your doctor if any of these side effects worsens. Also inform your doctor immediately if you experience severe fever with extreme tiredness, sudden changes in body weight or severe stomach pain along with dark urine after taking ABALAM 600/300. USES OF ABALAM 600/300 Manages HIV infection in adults, adolescents and in children (weighing above 25 kgs) HOW ABALAM 600/300 WORKS ABALAM 600/300 is an anti-retroviral medicine. It controls the multiplication of viral cell within the body, by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. It can also improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. DIRECTIONS FOR USE Take ABALAM 600/300 as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. ABALAM 600/300 can be taken with or without meals. Your doctor will decide the correct dose and for how long ABALAM 600/300 must be taken depending upon your age, body weight and severity of the infection. Do not stop taking ABALAM 600/300 without consulting your doctor as it may reduce its effectiveness. SIDE EFFECTS OF ABALAM 600/300 COMMON difficulty in sleeping feeling depressed headache, tiredness, dizziness nausea, diarrhoea fever, skin rash stomach pain loss of appetite irritated or runny nose hair loss UNCOMMON decrease in RBC, WBC, and platelets RARE Stop taking ABALAM 600/300 and contact your doctor immediately if you experience any of the following side effects: signs of allergic reactions (such as skin rash, fever, accompanied with sore throat, cough, nausea, vomiting, stomach pain, diarrhea, tiredness, joint pain, muscle pain, swelling of the neck, difficulty in breathing, mouth ulcers, occasional headaches, inflammation of the eye, low blood pressure, sense of tingling or numbness of hands or feet) pure red cell aplasia (failure of bone marrow to produce new red blood cells) signs of infections (such as fever, headache, stomach-ache, breathing difficulty) signs of auto-immune disorders (such as rapid or irregular heartbeat, tremor, hyperactivity, general weakness) signs of osteonecrosis (death of bone cells causing joint stiffness, pain in the hip, knee or shoulder and difficulty in moving) signs of liver problems (such as yellowing of the skin and whites of the eye, dark urine, light-coloured stools, loss of appetite, nausea, pain, tenderness on the right side of stomach) heart attack changes in body fat (such as increase fat in the shoulder and neck (buffalo hump), breast, and in the middle body or fat loss from the legs, arms, or face)

Marketer Intas Pharmaceuticals Ltd SALT COMPOSITION Recombinant Human Erythropoietin Alfa (6000IU) Salt Synonyms Epoetin Alfa Storage Store in a refrigerator (2 - 8°C). Do not freeze. Uses of Renocel Injection Anemia due to chronic kidney disease Anemia due to cancer chemotherapy Product introduction Renocel 6000IU Injection is a medicine that helps your bone marrow to produce more red blood cells. It is used to treat a type of anemia caused by kidney disease. It is also used to treat anemia caused by cancer chemotherapy and by taking medicines to treat HIV. Renocel 6000IU Injection is given by injection either under the skin or into a vein which will be decided by your doctor. Usually, the injections are given by a nurse or doctor. The dose depends on your body weight and the cause of your anemia. Iron supplements both before and during treatment may make this treatment more effective. Renocel 6000IU Injection needs to be stored in a fridge but used at room temperature. The most common side effects of taking this medicine include nausea, vomiting, fever, and increased blood pressure. It may also cause flu-like symptoms such as headache, tiredness, dizziness and aches and pains. These side effects are most common at the start of treatment but if they persist your doctor may be able to suggest ways of preventing or reducing them. Tell your doctor straight away if you get any serious side effects, including seizures (fits). Sometimes this medicine can cause serious blood clots that need urgent medical attention. Before using Renocel 6000IU Injection you should tell your doctor if you have uncontrolled high blood pressure, heart disease, or gout (disease of joint pain). You should also tell him/her what other medicines you are taking in case they affect this treatment. Your blood pressure should be checked often during this treatment by you or your doctor. You may also need other regular medical tests to be sure this medicine is not causing harmful effects. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Side effects of Renocel Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Renocel High blood pressure Nausea Vomiting Fever Rash Joint pain Headache Insomnia (difficulty in sleeping) Chills Cough Bone pain Muscle spasm Dizziness Vascular occlusion Injection site irritation Stomatitis (Inflammation of the mouth) Weight loss Decreased white blood cell count (lymphocytes) Increased glucose level in blood Blood clot in the blood vessels How to use Renocel Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Renocel Injection works Renocel 6000IU Injection is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Renocel 6000IU Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Renocel 6000IU Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding CONSULT YOUR DOCTOR Renocel 6000IU Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Marketer Emcure Pharmaceuticals Ltd SALT COMPOSITION Dolutegravir (50mg) + Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg) Storage Store below 30°C Uses of Viropil Tablet HIV infection Product introduction Viropil Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome). Viropil Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine. The most common side effects of this medicine are headaches, nasal congestion, diarrhea, nausea, weakness and tiredness, cough, and rash. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel lazy or weak, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with the side effects, so stay hydrated. Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular blood tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse. Benefits of Viropil Tablet In HIV infection Viropil Tablet prevents HIV from multiplying in the body. It helps control the infection and make the immune system work better. This lowers the chances of getting complications, such as new infections, and improves the quality of life. This medicine is always taken in combination with other antiretroviral medicines. It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important to take this medicine as prescribed by the doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of this combination of medicines and reduces the chances of HIV infection becoming resistant to antiretroviral medicines. Although taking this medicine does not prevent the passing of HIV to other people. Side effects of Viropil Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Viropil Headache Fever Abdominal pain Weakness Diarrhea Nausea Vomiting Joint pain Insomnia (difficulty in sleeping) Gastrointestinal disturbance Dizziness Abnormal dreams Depression Anxiety Itching Rash Fatigue Decreased phosphate level in blood General discomfort Cough Increased transaminase level in blood Hair loss Muscle disorders How to use Viropil Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Viropil Tablet may be taken with or without food, but it is better to take it at a fixed time. How Viropil Tablet works Viropil Tablet is an anti-HIV medication. It works by preventing the action of reverse transcriptase enzyme. This enzyme is responsible for production of HIV.

Marketer Cipla Ltd SALT COMPOSITION Darunavir (600mg) + Ritonavir (100mg) Storage Store below 30°C Uses of Daruvir R Tablet Treatment of HIV infection Product introduction Daruvir 600 R Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome). Daruvir 600 R Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine. The most common side effects of this medicine are headaches, nasal congestion, diarrhea, nausea, weakness and tiredness, cough, and rash. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel lazy or weak, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with the side effects, so stay hydrated. Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular blood tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse. Benefits of Daruvir R Tablet In Treatment of HIV infection Daruvir 600 R Tablet controls HIV infection by preventing the virus from multiplying in the body. It also helps your immune system to work better and may decrease your chance of developing HIV-related illnesses such as AIDS. This ensures that you live a long and healthy life. Avoid skipping doses and follow your doctor’s instructions carefully to get maximum benefit. Taking Daruvir 600 R Tablet along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people. Side effects of Daruvir R Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Daruvir R Diarrhea Headache Nausea Abdominal pain Rash Vomiting How to use Daruvir R Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Daruvir 600 R Tablet may be taken with or without food, but it is better to take it at a fixed time. How Daruvir R Tablet works Daruvir 600 R Tablet is a combination of two anti-HIV medicines. Altogether, Darunavir and Ritonavir work by interfering with an enzyme (protease), which is required by HIV-infected cells to make new viruses. This stops the production of new viruses. This is how it works to treat HIV infections.

Marketer Cipla Ltd SALT COMPOSITION Darunavir (800mg) + Ritonavir (100mg) Storage Store below 30°C Uses of Daruvir R Tablet Treatment of HIV infection Product introduction Daruvir 800 R Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome). Daruvir 800 R Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine. The most common side effects of this medicine are headaches, nasal congestion, diarrhea, nausea, weakness and tiredness, cough, and rash. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel lazy or weak, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with the side effects, so stay hydrated. Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular blood tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse. Benefits of Daruvir R Tablet In Treatment of HIV infection Daruvir 800 R Tablet controls HIV infection by preventing the virus from multiplying in the body. It also helps your immune system to work better and may decrease your chance of developing HIV-related illnesses such as AIDS. This ensures that you live a long and healthy life. Avoid skipping doses and follow your doctor’s instructions carefully to get maximum benefit. Taking Daruvir 800 R Tablet along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people. Side effects of Daruvir R Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Daruvir R Diarrhea Headache Nausea Abdominal pain Rash Vomiting How to use Daruvir R Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Daruvir 800 R Tablet may be taken with or without food, but it is better to take it at a fixed time. How Daruvir R Tablet works Daruvir 800 R Tablet is a combination of two anti-HIV medicines. Altogether, Darunavir and Ritonavir work by interfering with an enzyme (protease), which is required by HIV-infected cells to make new viruses. This stops the production of new viruses. This is how it works to treat HIV infections.

Marketer Cipla Ltd SALT COMPOSITION Lamivudine (150mg) + Zidovudine (300mg) + Nevirapine (200mg) Storage Store below 30°C Uses of Duovir N Tablet HIV infection Product introduction Duovir N Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome). Duovir N Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine. The most common side effects of this medicine are headaches, nasal congestion, diarrhea, nausea, weakness and tiredness, cough, and rash. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel lazy or weak, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with the side effects, so stay hydrated. Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular blood tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse. Benefits of Duovir N Tablet In HIV infection Duovir N Tablet prevents the HIV virus from multiplying in your body. It helps control the infection and makes your immune system work better. This lowers your chances of getting complications such as new infections and improves your quality of life. It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important that you take this medicine as prescribed, following the dosage recommended by your doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of your combination of medicines and reduces the chances of your HIV infection becoming resistant to antiretroviral medicines. However, taking this medicine will not prevent you from passing HIV to other people. Side effects of Duovir N Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Duovir N Headache Insomnia (difficulty in sleeping) Rash Decreased white blood cell count (neutrophils) Fever Hair loss Joint pain Muscle disorders Fatigue General discomfort Cough How to use Duovir N Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duovir N Tablet may be taken with or without food, but it is better to take it at a fixed time.

INTRODUCTION ABOUT VALCYTE 450MG TABLET VALCYTE 450MG TABLET contains Valganciclovir which belongs to the group of medicines called Antiviral agents. It is used in adults (with acquired immunodeficiency syndrome) to manage cytomegalovirus (CMV) infection of the retina of the eye which generally cause vision problems and blindness. VALCYTE 450MG TABLET is also used in adults and children to manage cytomegalovirus (CMV) infection who are not infected with CMV or who had received an organ transplant from someone who earlier had CMV infection. VALCYTE 450MG TABLET is not recommended for use in patients allergic (hypersensitive) to Valganciclovir, and/or Ganciclovir. Before taking VALCYTE 450MG TABLET, inform your doctor if are undergoing radiotherapy/hemodialysis, and/or suffer from low red blood cell, white blood cell or platelets, kidney/liver problems. VALCYTE 450MG TABLET is not recommended for use in pregnant women unless it is clearly necessary since it may cause harm to the unborn baby. It is also not recommended for use in breastfeeding women. VALCYTE 450MG TABLET should be used with caution in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 65 years and above) after consulting the doctor. The most common side effects of taking VALCYTE 450MG TABLET are oral thrush (fungal infection), headache, shortness of breath, abdominal pain, loss of appetite, nausea, vomiting, and/or diarrhea. Consult your doctor if any of these symptoms worsens. USES OF VALCYTE 450MG TABLET Manage cytomegalovirus (CMV) infection of the retina of the eye in adult patients with acquired immunodeficiency syndrome (AIDS). Prevents cytomegalovirus (CMV) infection who are not infected with CMV or in patients who had received an organ transplant from someone who earlier had CMV infection HOW VALCYTE 450MG TABLET WORKS VALCYTE 450MG TABLET works by managing the multiplication of virus in human cells by decreasing its growth which results in inhibition of production of new virus thus managing and managing the spread of infection to other parts of the body in affected individuals. DIRECTIONS FOR USE Take VALCYTE 450MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF VALCYTE 450MG TABLET COMMON thrush & oral thrush (fungal infection) upper respiratory tract infection such as sinusitis, tonsillitis headache cough, shortness of breath abdominal pain, loss of appetite, nausea/vomiting, diarrhea, weight loss eczema (skin inflammation) tiredness, fever influenza signs of urine infection such as fever, passing urine more often, and/or pain (while passing urine) skin infection signs of mild allergic reaction such as red, itchy skin feeling depressed, anxious or confused trouble sleeping feeling numb/weak in hands/feet changes in sense of touch, tingling/tickling/pricking/burning sensation altered taste, chills eye inflammation/pain or sight problems ear pain signs of low blood pressure such as feeling dizzy/faint difficulty while swallowing constipation, wind, indigestion, stomach pain, swelling of abdomen mouth ulcers night sweats itching, rash hair loss back pain, muscle/joint pain, muscle spasms feeling dizzy, weak/generally unwell UNCOMMON feeling agitated tremor/shaking deafness irregular heartbeat red itchy welt, dry skin blood in urine chest pain RARE Stop taking VALCYTE 450MG TABLET and contact your doctor if you experience any of the following side effects: signs of allergic reaction (anaphylactic shock) such as raised, itchy skin rash, sudden swelling of throat, face, lips/mouth resulting in difficulty while swallowing/breathing, and/or sudden swelling of the hands, feet/ankles. signs of infection (due to low white blood cell count) such as sore throat, mouth ulcer, and/or fever signs of low red blood cell count such as shortness of breath, tiredness, palpitation, and/or pale skin signs of blood infection (sepsis) such as fever, chills, palpitation, confusion, and/or slurred speech signs of low platelet count such as bleeding/bruising, blood in urine/stools, and/or bleeding from gums severely low blood cell count pancreatitis (inflammation of pancreas) associated with severe stomach pain fits hallucinations abnormal thoughts/feelings, losing contact with reality failure of kidney function HOW TO MANAGE SIDE EFFECTS Constipation Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (such as going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate managements for constipation.

Spnib 50mg tablet consists of the active ingredient Dasatinib. It is prescribed for adults and children above one year of age with Chronic Myeloid Leukemia. This medicine is used to treat newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in the chronic phase and Ph+ acute lymphoblastic leukemia in patients resistant to other therapies. Chronic Myeloid Leukemia refers to a type of blood cancer that makes the body produce too many white blood cells that happen due to alteration in the Philadelphia chromosome. Acute Lymphoblastic Leukemia is the most common form of blood cancer that affects children. In this case, the lymphocytes of white blood cells multiply too quickly and live too long. The common side effects that are likely to associate with Spnib 50mg tablet are diarrhea, headache, cough, rash, nausea, tiredness, vomiting, muscle pain, weakness, low appetite, and high or low blood pressure. Inform your doctor if these side effects disturb or persist you.

INTRODUCTION ABOUT RITUXIREL 100 INJECTION RITUXIREL 100 INJECTION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals). It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). RITUXIREL 100 INJECTION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion). Before receiving RITUXIREL 100 INJECTION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. RITUXIREL 100 INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving RITUXIREL 100 INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with RITUXIREL 100 INJECTION. The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens. USES OF RITUXIREL 100 INJECTION It is used to manage: Blood cancer (Chronic lymphocytic leukaemia) Lymph cancer (Non-Hodgkin’s Lymphoma) Rheumatoid arthritis (joint pain and inflammation) Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals) HOW RITUXIREL 100 INJECTION WORKS RITUXIREL 100 INJECTION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases. DIRECTIONS FOR USE RITUXIREL 100 INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RITUXIREL 100 INJECTION COMMON increased infections (bacterial, viral or fungal) low RBC, WBC and platelet counts in blood nausea, vomiting, diarrhea, stomach pain, constipation, indigestion mouth ulcers hair loss fever, chills, pneumonia, shingles, cold, sinusitis thrush, urinary tract infection headache, dizziness, tiredness, weakness hepatitis B infection high blood sugar and cholesterol levels weight loss, lack of appetite numbness, tingling, pricking, burning sensation on the skin restlessness, problems in falling asleep, anxiety, depression flushing (skin redness) eye inflammation or watery eyes ringing sound in the ears, ear pain uneven or fast heart rate, high or low blood pressure shortness of breath, runny nose, nasal itching and repeated sneezing increased sweating, night sweats muscle pain, joint pain, back pain, neck pain pain while passing urine fungal foot infection (athlete’s foot) tremors (shakiness) swelling of the hands or ankles UNCOMMON blood clotting problems changes in taste slow heart rate chest tightness and lung problems RARE Contact your doctor immediately if you experience any of the following side effects: fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems) signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever)