'proinflammtory cytokines'

Ichmune C contains Cyclosporine an immunosuppressant that blocks the production of pro-inflammtory cytokines and is approved for use by USFDA for the long terms management of canine atopic dermatitits and for use in cats with atopic syndrome. Ichmune C offers a gradual dose tapering protocol that helps veterinarians to tailor dose as per the requirements of patients.

DEXAPAR Dexamethasone Eye Drops contain Dexamethasone, a potent corticosteroid that helps to reduce inflammation in the eyes. These eye drops are typically used to manage a variety of eye conditions involving inflammation. Here’s a breakdown of the primary uses: 🔹 Primary Uses Treatment of Inflammatory Eye Conditions Dexamethasone is commonly used to treat eye conditions where inflammation is present, such as: Uveitis (inflammation of the uvea, which is part of the eye) Iritis (inflammation of the iris) Conjunctivitis (inflammation of the conjunctiva) Keratitis (inflammation of the cornea) Post-Surgical Inflammation Used after eye surgeries, such as cataract surgery, to control post-operative inflammation and prevent discomfort. Allergic Conjunctivitis May be used for severe allergic reactions causing inflammation in the eye (though often replaced by non-steroidal anti-inflammatory drugs or other treatments). 🔹 How It Works Dexamethasone is a corticosteroid that works by suppressing the immune system to decrease inflammation. It inhibits the release of substances in the body that cause inflammation, such as prostaglandins and cytokines. ⚠️ Common Side Effects Eye irritation or stinging upon application Increased intraocular pressure (which can lead to glaucoma with long-term use) Blurred vision (temporary) Cataract formation (with prolonged use) Eye infections: Prolonged use may increase the risk of developing eye infections. 🔹 Usage Tips Dosage: Typically, 1–2 drops in the affected eye(s), 2 to 4 times a day, depending on the severity of inflammation. Application: Wash your hands before using the eye drops. Tilt your head back and pull down your lower eyelid to form a pocket. Drop the medication into the pocket and close your eye gently. Blink to spread the medication evenly. If using multiple eye medications, wait about 5 minutes between applying each. Contact Lenses: Remove contact lenses before applying the drops and wait 15 minutes before reinserting them. 🔹 Precautions Glaucoma and Cataracts: Prolonged use of Dexamethasone can increase the risk of glaucoma and cataracts, especially in people with a history of these conditions. Infections: Dexamethasone may mask signs of infection. Be cautious if you have an active eye infection. Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding, as corticosteroids may not be suitable in these situations. Long-Term Use: Prolonged or repeated use of corticosteroid eye drops requires careful monitoring by an eye care professional. 🔹 Long-Term Use Dexamethasone Eye Drops are generally not recommended for long-term use unless prescribed by a doctor because of the risk of increasing intraocular pressure, glaucoma, and other complications like cataract formation.

CYCLOSIM 0.1% Eye Drops contain Cyclosporine A, which is an immunosuppressive drug. These eye drops are primarily used for conditions related to dry eyes and inflammation. Here's a detailed overview of its uses: 🔹 Primary Uses Treatment of Dry Eye Disease (Keratoconjunctivitis Sicca) Cyclosporine A in CYCLOSIM 0.1% is commonly used to treat dry eye disease associated with inflammation. It helps by increasing tear production and reducing the inflammation in the eye, making it useful for those who have chronic dry eye caused by insufficient tear production. Inflammatory Eye Conditions It can help reduce inflammation in the eyes, particularly in conditions where the immune system is involved in causing eye irritation or dry eye symptoms. 🔹 How It Works Cyclosporine A is an immunosuppressive agent that modulates the immune system by inhibiting the production of certain cytokines (especially interleukin-2). In the context of dry eyes, this helps to reduce inflammation in the tear glands and promotes tear production. ⚠️ Common Side Effects Burning or stinging sensation in the eye upon application Redness in the eye Eye discomfort or feeling of a foreign object in the eye Watery eyes Temporary blurred vision (typically resolves shortly after application) 🔹 Usage Tips Frequency: Typically applied twice a day, about 12 hours apart, in each affected eye. Application: Wash your hands thoroughly before using the drops. Tilt your head back and pull down the lower eyelid to form a small pocket. Instill 1 drop into the pocket of the lower eyelid. Close your eye gently and blink several times to help spread the medication. If you use other eye medications, wait at least 5–10 minutes between applications. Contact Lenses: Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting. 🔹 Precautions Infections: If you have an active eye infection, this medication may not be appropriate as it could exacerbate it. Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding before using Cyclosporine A eye drops. Other Medications: Always inform your doctor if you are using other eye medications or oral medications that may interact with Cyclosporine.

INTRODUCTION ABOUT RITUXIREL 100 INJECTION RITUXIREL 100 INJECTION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals). It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). RITUXIREL 100 INJECTION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion). Before receiving RITUXIREL 100 INJECTION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. RITUXIREL 100 INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving RITUXIREL 100 INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with RITUXIREL 100 INJECTION. The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens. USES OF RITUXIREL 100 INJECTION It is used to manage: Blood cancer (Chronic lymphocytic leukaemia) Lymph cancer (Non-Hodgkin’s Lymphoma) Rheumatoid arthritis (joint pain and inflammation) Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals) HOW RITUXIREL 100 INJECTION WORKS RITUXIREL 100 INJECTION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases. DIRECTIONS FOR USE RITUXIREL 100 INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RITUXIREL 100 INJECTION COMMON increased infections (bacterial, viral or fungal) low RBC, WBC and platelet counts in blood nausea, vomiting, diarrhea, stomach pain, constipation, indigestion mouth ulcers hair loss fever, chills, pneumonia, shingles, cold, sinusitis thrush, urinary tract infection headache, dizziness, tiredness, weakness hepatitis B infection high blood sugar and cholesterol levels weight loss, lack of appetite numbness, tingling, pricking, burning sensation on the skin restlessness, problems in falling asleep, anxiety, depression flushing (skin redness) eye inflammation or watery eyes ringing sound in the ears, ear pain uneven or fast heart rate, high or low blood pressure shortness of breath, runny nose, nasal itching and repeated sneezing increased sweating, night sweats muscle pain, joint pain, back pain, neck pain pain while passing urine fungal foot infection (athlete’s foot) tremors (shakiness) swelling of the hands or ankles UNCOMMON blood clotting problems changes in taste slow heart rate chest tightness and lung problems RARE Contact your doctor immediately if you experience any of the following side effects: fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems) signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever)

INTRODUCTION ABOUT RITUXIREL 500MG INJECTION RITUXIREL 500MG INJECTION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals). It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). RITUXIREL 500MG INJECTION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion). Before receiving RITUXIREL 500MG INJECTION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. RITUXIREL 500MG INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving RITUXIREL 500MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with RITUXIREL 500MG INJECTION. The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens. USES OF RITUXIREL 500MG INJECTION It is used to manage: Blood cancer (Chronic lymphocytic leukaemia) Lymph cancer (Non-Hodgkin’s Lymphoma) Rheumatoid arthritis (joint pain and inflammation) Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals) HOW RITUXIREL 500MG INJECTION WORKS RITUXIREL 500MG INJECTION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases. DIRECTIONS FOR USE RITUXIREL 500MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RITUXIREL 500MG INJECTION COMMON increased infections (bacterial, viral or fungal) low RBC, WBC and platelet counts in blood nausea, vomiting, diarrhea, stomach pain, constipation, indigestion mouth ulcers hair loss fever, chills, pneumonia, shingles, cold, sinusitis thrush, urinary tract infection headache, dizziness, tiredness, weakness hepatitis B infection high blood sugar and cholesterol levels weight loss, lack of appetite numbness, tingling, pricking, burning sensation on the skin restlessness, problems in falling asleep, anxiety, depression flushing (skin redness) eye inflammation or watery eyes ringing sound in the ears, ear pain uneven or fast heart rate, high or low blood pressure shortness of breath, runny nose, nasal itching and repeated sneezing increased sweating, night sweats muscle pain, joint pain, back pain, neck pain pain while passing urine fungal foot infection (athlete’s foot) tremors (shakiness) swelling of the hands or ankles UNCOMMON blood clotting problems changes in taste slow heart rate chest tightness and lung problems RARE Contact your doctor immediately if you experience any of the following side effects: fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems) signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever) HOW TO MANAGE SIDE EFFECTS Constipation Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.