Nor-ADR Injection is a brand of Noradrenaline (Norepinephrine) Bitartrate Injection, manufactured by American Remedies. It is primarily used in critical care settings to manage severe hypotension (low blood pressure) and shock. ________________________________________ ✅ Primary Uses Nor-ADR Injection is indicated for: • Septic Shock: A life-threatening condition caused by severe infection leading to dangerously low blood pressure. • Cardiogenic Shock: A state where the heart is unable to pump sufficient blood to meet the body's needs. Anaphylactic Shock: A severe allergic reaction causing a sudden drop in blood pressure. • Hypotension During Surgery or Trauma: To maintain adequate blood pressure during and after surgical procedures or traumatic events. • Cardiac Arrest: As an adjunct in the management of cardiac arrest to improve blood flow to vital organs. These indications are supported by clinical guidelines and pharmacological references. ________________________________________ ⚙️ Mechanism of Action Noradrenaline is a potent vasopressor that works by: Alpha-1 Adrenergic Receptor Activation: Causing vasoconstriction, which increases systemic vascular resistance and raises blood pressure. • Beta-1 Adrenergic Receptor Activation: Increasing heart rate and myocardial contractility, thereby enhancing cardiac output. This dual action helps restore blood pressure and improve perfusion to vital organs in shock states. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Administration: Should be administered intravenously under strict medical supervision, typically in an intensive care unit (ICU) setting. • Monitoring: Continuous monitoring of blood pressure and heart rate is essential during administration. • Contraindications: Should not be used in patients with mesenteric or peripheral vascular thrombosis unless absolutely necessary. Common Side Effects: • Hypertension (high blood pressure) • Headache Nausea • Anxiety • Dizziness Serious Side Effects: • Arrhythmias (irregular heartbeats) • Tissue necrosis at the injection site • Reduced renal perfusion leading to renal failure Immediate medical attention is required if any serious side effects occur.

Nitrocan 25 Injection is a brand of Nitroglycerin Injection 25 mg/5 mL, manufactured by American Remedies. It is primarily used in hospital settings for the management of certain cardiovascular conditions. ________________________________________ ✅ Primary Uses Nitrocan 25 Injection is indicated for: • Angina Pectoris: To treat and prevent chest pain caused by reduced blood flow to the heart. • Acute Myocardial Infarction (Heart Attack): To alleviate chest pain and improve blood flow to the heart muscle. Hypertension During Surgery: To control high blood pressure during and after surgical procedures. • Congestive Heart Failure: To reduce the workload on the heart and improve symptoms. ________________________________________ ⚙️ Mechanism of Action Nitroglycerin is a nitrate that, once administered, is converted into nitric oxide in the body. This leads to the relaxation and dilation of blood vessels, improving blood flow and reducing the heart's workload. ________________________________________ ⚠️ Precautions • Contraindications: Should not be used in patients with severe anemia, hypotension, or those taking medications for erectile dysfunction (e.g., sildenafil, tadalafil) due to the risk of a significant drop in blood pressure. • Monitoring: Requires careful monitoring of blood pressure and heart rate during administration. • Administration: Administered intravenously under medical supervision; dosage and duration are determined by the healthcare provider. ________________________________________ 💊 Common Side Effects • Headache • Dizziness or lightheadedness • Hypotension (low blood pressure) • Nausea or vomiting • Flushing

Mucanix Injection is a brand of Acetylcysteine Injection, manufactured by American Remedies. Acetylcysteine is a mucolytic agent that helps in thinning and loosening mucus in the airways, making it easier to cough up and clear the airways. ________________________________________ ✅ Primary Uses Mucanix Injection is primarily used for: • Respiratory Disorders: Conditions such as chronic bronchitis, asthma, and cystic fibrosis, where there is excessive mucus production. • Paracetamol (Acetaminophen) Overdose: As an antidote to prevent liver damage when administered within 8 hours of overdose. ________________________________________ ⚙️ Mechanism of Action Acetylcysteine works by: • Breaking down mucus: It reduces the viscosity of mucus, facilitating easier expectoration. • Restoring glutathione levels: In cases of paracetamol overdose, it replenishes glutathione, a vital antioxidant, aiding in detoxification and protecting the liver. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Allergy: Do not use if allergic to acetylcysteine or any of its components. • Asthma: Use with caution in patients with asthma; monitoring is required. • Pregnancy and Breastfeeding: Consult a doctor before use during pregnancy or breastfeeding. Common Side Effects: • Nausea • Vomiting • Rash • Fever • Headache Serious Side Effects: • Anaphylactic reactions (rare) • Hypotension • Tachycardia If you experience any of these serious side effects, seek immediate medical attention.

MNOphyllin Injection is a brand of Aminophylline Injection, manufactured by American Remedies. Aminophylline is a bronchodilator that works by relaxing the muscles of the air passages in the lungs, making it easier to breathe. ________________________________________ ✅ Primary Uses MNOphyllin Injection is primarily used for: • Asthma: A chronic condition where the airways become inflamed and narrow, leading to difficulty in breathing. • Chronic Obstructive Pulmonary Disease (COPD): A group of lung diseases that block airflow and make breathing difficult. • Bronchospasm: A condition where the muscles around the airways tighten, leading to wheezing and shortness of breath. It is administered intravenously in a hospital setting under medical supervision. ________________________________________ ⚙️ Mechanism of Action Aminophylline works by: • Relaxing the bronchial muscles: This leads to the widening of the air passages, making it easier to breathe. • Increasing the strength of the diaphragm: This enhances the ability to breathe effectively. • Reducing airway responsiveness to irritants: This helps in decreasing inflammation and bronchoconstriction. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Medical History: Inform your doctor if you have a history of heart disease, liver or kidney disorders, or seizures. • Pregnancy and Breastfeeding: Consult your doctor before use if pregnant or breastfeeding. • Drug Interactions: Certain medications can interact with Aminophylline, so it's essential to inform your healthcare provider about all medicines you are taking. Common Side Effects: • Nausea • Vomiting • Headache • Restlessness • Dizziness Serious Side Effects: • Irregular heartbeats • Seizures • Severe allergic reactions If you experience any of these serious side effects, seek immediate medical attention.

Colistican 3 Injection is an intravenous formulation containing Colistimethate Sodium 3 Million IU, manufactured by American Remedies. It is primarily used to treat severe infections caused by multidrug-resistant Gram-negative bacteria. ________________________________________ 🩺 Uses of Colistican 3 Injection Colistican 3 Injection is indicated for: • Ventilator-Associated Pneumonia (VAP): A lung infection acquired during mechanical ventilation. • Bloodstream Infections (Sepsis): Infections caused by resistant bacteria entering the bloodstream. • Urinary Tract Infections (UTIs): Caused by multidrug-resistant Gram-negative organisms. • Intra-abdominal Infections: Such as peritonitis. • Cystic Fibrosis: For chronic pulmonary infections due to Pseudomonas aeruginosa in both adults and children. ________________________________________ 💊 Mechanism of Action Colistimethate sodium is a prodrug that, upon administration, is converted to colistin. Colistin binds to the bacterial cell membrane, disrupting its structure and leading to cell death. It is particularly effective against aerobic Gram-negative bacteria with hydrophobic outer membranes. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Renal Function: Use with caution in patients with kidney impairment. • Neurological Effects: Monitor for signs of neurotoxicity, including dizziness and muscle weakness. • Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding. Common Side Effects: • Injection site reactions • Renal toxicity • Neurological symptoms (e.g., confusion, dizziness) • Gastrointestinal disturbances (e.g., nausea, vomiting) • Muscle weakness

Colistican 2 Injection is a brand of Colistimethate Sodium for Injection, manufactured by American Remedies. It is a polymyxin-class antibiotic used to treat serious infections caused by multidrug-resistant Gram-negative bacteria. ________________________________________ 🩺 Uses of Colistican 2 Injection Colistican 2 Injection is primarily indicated for: • Ventilator-Associated Pneumonia (VAP): A lung infection acquired during mechanical ventilation. • Bacteremia (Bloodstream Infection): Infections caused by resistant bacteria entering the bloodstream. • Lower Respiratory Tract Infections: Including severe cases of pneumonia and bronchitis. • Urinary Tract Infections (UTIs): Caused by multidrug-resistant Gram-negative organisms. These infections are typically caused by pathogens such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, which are resistant to multiple antibiotics. ________________________________________ 💊 Mechanism of Action Colistimethate sodium is a prodrug that, upon administration, is converted to colistin. Colistin binds to the bacterial cell membrane, disrupting its structure and leading to cell death. It is particularly effective against aerobic Gram-negative bacteria with hydrophobic outer membranes. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Renal Function: Use with caution in patients with kidney impairment. • Neurological Effects: Monitor for signs of neurotoxicity, including dizziness and muscle weakness. • Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding. Common Side Effects: • Injection site reactions • Renal toxicity • Neurological symptoms (e.g., confusion, dizziness) • Gastrointestinal disturbances (e.g., nausea, vomiting) • Muscle weakness

Colistican 1 Injection is a brand of Colistimethate Sodium for Injection manufactured by American Remedies. Colistimethate sodium is a polymyxin-class antibiotic, also known as polymyxin E, used to treat serious infections caused by multidrug-resistant Gram-negative bacteria. ________________________________________ 🩺 Uses of Colistican 1 Injection Colistican 1 Injection is primarily used for: • Multidrug-Resistant Infections: Especially those caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. • Ventilator-Associated Pneumonia (VAP): A lung infection acquired during mechanical ventilation. • Urinary Tract Infections (UTIs): Caused by resistant Gram-negative bacteria. • Bloodstream Infections (Sepsis): Resulting from resistant pathogens. • Intra-abdominal Infections: Such as peritonitis. • Cystic Fibrosis: For chronic pulmonary infections due to Pseudomonas aeruginosa in both adults and children. ________________________________________ 💊 Mechanism of Action Colistimethate sodium is a prodrug that, upon administration, is converted to colistin. Colistin binds to the bacterial cell membrane, disrupting its structure and leading to cell death. It is particularly effective against aerobic Gram-negative bacteria with hydrophobic outer membranes. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Renal Function: Use with caution in patients with kidney impairment. • Neurological Effects: Monitor for signs of neurotoxicity, including dizziness and muscle weakness. • Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding. Common Side Effects: • Injection site reactions • Renal toxicity • Neurological symptoms (e.g., confusion, dizziness) • Gastrointestinal disturbances (e.g., nausea, vomiting) • Muscle weakness

Clocivir 500 Injection is an intravenous formulation containing Acyclovir 500 mg, manufactured by American Remedies. It is primarily used to treat severe viral infections caused by herpes viruses. ________________________________________ 🩺 Uses of Clocivir 500 Injection Clocivir 500 Injection is indicated for: • Herpes Simplex Infections in Immunocompromised Patients: Including severe primary or non-primary genital herpes. • Herpes Simplex Encephalitis: A serious brain infection caused by the herpes simplex virus. • Neonatal Herpes Simplex Virus Infection: In newborns. • Varicella-Zoster Infections in Immunocompromised Patients: Such as severe cases of chickenpox or shingles. • Severe Herpes Zoster (Shingles): In immunocompetent patients with very severe acute local or systemic manifestations. ________________________________________ 💊 Mechanism of Action Acyclovir, the active ingredient in Clocivir, is a synthetic purine nucleoside analogue. It exerts its antiviral effects by inhibiting viral DNA synthesis, thereby preventing the replication of herpes viruses. Acyclovir is converted to its active form, Acyclovir Triphosphate, within infected cells, which then interferes with viral DNA polymerase. ________________________________________ ⚠️ Precautions • Administration: Clocivir 500 Injection should be administered by a healthcare professional through slow intravenous infusion over a 1-hour period to minimize the risk of kidney damage. • Hydration: Adequate hydration is essential during treatment to prevent dehydration and kidney damage. • Kidney Function: Use with caution in patients with pre-existing kidney conditions. • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Clocivir 250 Injection is an intravenous formulation containing Acyclovir 250 mg, manufactured by American Remedies. It is primarily used to treat severe viral infections caused by herpes viruses. ________________________________________ 🩺 Uses of Clocivir 250 Injection Clocivir 250 Injection is indicated for: • Herpes Simplex Virus Infections: Including severe cases in immunocompromised patients. • Genital Herpes: Especially primary or non-primary severe cases. • Herpes Zoster (Shingles): In immunocompetent patients with severe manifestations. • Chickenpox (Varicella Zoster Virus Infection): Particularly in immunocompromised individuals. • Herpes Simplex Encephalitis: A severe brain infection caused by the herpes simplex virus. ________________________________________ 💊 Mechanism of Action Acyclovir, the active ingredient in Clocivir, is a synthetic purine nucleoside analogue. It exerts its antiviral effects by inhibiting viral DNA synthesis, thereby preventing the replication of herpes viruses. Acyclovir is converted to its active form, Acyclovir Triphosphate, within infected cells, which then interferes with viral DNA polymerase . ________________________________________ ⚠️ Precautions • Administration: Clocivir 250 Injection should be administered by a healthcare professional through slow intravenous infusion over a 1-hour period to minimize the risk of kidney damage . • Hydration: Adequate hydration is essential during treatment to prevent dehydration and kidney damage. • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding. • Drug Interactions: Inform your healthcare provider about all other medications you are taking to avoid potential interactions.