Dixin Injection Salt: Digoxin (0.5mg) Description Dixin 0.25mg Injection is a medicine used for the emergency treatment of heart failure and abnormal heart rhythm (arrhythmia). It helps to provide symptomatic relief by making the heart pump blood more efficiently. It helps in arrhythmia by restoring a steady and normal heartbeat. Dixin 0.25mg Injection is a medicine used for the emergency treatment of heart failure and abnormal heart rhythm (arrhythmia). It helps to provide symptomatic relief by making the heart pump blood more efficiently. It helps in arrhythmia by restoring a steady and normal heartbeat. Dixin 0.25mg Injection is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. Doctor may closely monitor your blood pressure, heart rate and ECG till you became stable. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Common side effects of this medicine include nausea, vomiting, diarrhea, dizziness, and visual disturbances. Consult your doctor if these effects bother you. This medicine is used with caution for some people. Thus, you must inform the doctor if you are suffering from any kidney disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Benefits 1. In Heart failure: Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Dixin 0.25mg Injection makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure. It is given as an injection by a doctor or nurse and should not be self-administered. This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes (such as eating healthily and keeping active) to help this medicine be effective. 2. In Arrhythmia: Dixin 0.25mg Injection is used to stabilize heart rhythms (particularly atrial fibrillation). It helps in normalizing an abnormal heart rhythm, preventing it from occurring in the first place, or slowing down the heart rate during an episode.' Side Effects Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Common side effects of Dixin: - Visual impairment - Nausea - Vomiting - Diarrhea - Dizziness - Arrhythmia (irregular heartbeats)

Dixin Syrup Salt: Digoxin (3mg) Description Dixin 3mg Syrup is a medicine used for the treatment of heart failure in combination with other medicines. It helps to provide symptomatic relief by making the heart pump blood more efficiently. This medicine is also used to treat abnormal heart rhythm (arrhythmia). Dixin 3mg Syrup is a medicine used for the treatment of heart failure in combination with other medicines. It helps to provide symptomatic relief by making the heart pump blood more efficiently. This medicine is also used to treat abnormal heart rhythm (arrhythmia). Dixin 3mg Syrup restores and maintains a normal and steady heartbeat. It should be taken regularly as advised by the doctor. You may take it with or without food but it is better to take this medicine at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. Common side effects of this medicine include nausea, vomiting, diarrhea, dizziness, and visual disturbances. Consult your doctor if these effects bother you. This medicine is used with caution for some people. Thus, you must inform the doctor if you are suffering from any kidney disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Your doctor may advise for regular monitoring of kidney function while you are taking this medicine. Benefits 1. In Heart failure: Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Dixin 3mg Syrup makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure. This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes (such as eating healthily and keeping active) to help this medicine be effective. Take it regularly and keep taking it even if you feel better. 2. In Arrhythmia: Dixin 3mg Syrup is used to stabilize heart rhythms (particularly atrial fibrillation). It helps in normalizing an abnormal heart rhythm, preventing it from occurring in the first place, or slowing down the heart rate during an episode.' Side Effects Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Common side effects of Dixin: - Visual impairment - Skin rash - Nausea - Vomiting - Diarrhea - Dizziness - Arrhythmia (irregular heartbeats)

Dixin Tablet Salt: Digoxin (0.25mg) Description Dixin Tablet is a medicine used for the treatment of heart failure in combination with other medicines. It helps to provide symptomatic relief by making the heart pump blood more efficiently. This medicine is also used to treat abnormal heart rhythm (arrhythmia). Dixin Tablet is a medicine used for the treatment of heart failure in combination with other medicines. It helps to provide symptomatic relief by making the heart pump blood more efficiently. This medicine is also used to treat abnormal heart rhythm (arrhythmia). Dixin Tablet restores and maintains a normal and steady heartbeat. It should be taken regularly as advised by the doctor. You may take it with or without food but it is better to take this medicine at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. Common side effects of this medicine include nausea, vomiting, diarrhea, dizziness, and visual disturbances. Consult your doctor if these effects bother you. This medicine is used with caution for some people. Thus, you must inform the doctor if you are suffering from any kidney disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Your doctor may advise for regular monitoring of kidney function while you are taking this medicine. Benefits 1. In Heart failure: Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Dixin Tablet makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure. This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes (such as eating healthily and keeping active) to help this medicine be effective. Take it regularly and keep taking it even if you feel better. 2. In Arrhythmia: Dixin Tablet is used to stabilize heart rhythms (particularly atrial fibrillation). It helps in normalizing an abnormal heart rhythm, preventing it from occurring in the first place, or slowing down the heart rate during an episode. Side Effects Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Common side effects of Dixin: - Visual impairment - Skin rash - Nausea - Vomiting - Diarrhea - Dizziness - Arrhythmia (irregular heartbeats)

Isolin 2mg Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Isoprenaline (2mg) Storage Store below 25°C Uses of Isolin Injection Heart Failure Treatment of Bradycardia Decreased blood pressure Treatment of Cardiac arrest Product introduction Isolin 2mg Injection is a medicine used for the treatment of bradycardia (decreased heart rate) and heart block. It is also used for emergency treatment of cardiac arrest. This medicine increases the heart rate and blood pressure. Isolin 2mg Injection is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. Doctor may closely monitor your blood pressure and heart rate till you became stable. You should continue all your other medicines that are advised for your long-term treatment even after this injection. This medicine may cause side effects like headache, palpitations, and flushing in some patients. You must inform doctor if you are suffering from any liver or kidney disease. Also let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it. Benefits of Isolin Injection In Treatment of Bradycardia Isolin 2mg Injection helps to bring back the blood pressure within normal range. This relaxes the heart, treats decreased heart rate (bradycardia) and prevents any sudden fall of blood pressure or even serious complications that might have otherwise followed due to low blood pressure. In Treatment of Cardiac arrest Isolin 2mg Injection stimulates the heart and promotes blood flow. It is a proven life-saving treatment for people whose hearts have stopped working all of a sudden due to an emergency condition called cardiac arrest. Its action is fast though it has a very short duration of action. It is given in an emergency condition to save life by a trained healthcare professional only. Side effects of Isolin Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Isolin Headache Palpitations Increased heart rate Flushing (sense of warmth in the face, ears, neck and trunk) Restlessness Tremors How to use Isolin Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Isolin Injection works Isolin 2mg Injection makes the heart pump blood with more strength and force, therefore, increasing the blood pressure.

Milicor 10mg Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Milrinone (10mg) Storage Store below 30°C Uses of Milicor Injection Heart Failure Product introduction Milicor 10mg Injection is a medicine used for short-term treatment of heart failure. It is also used to treat patients with a poorly functioning heart after heart surgery. It makes the heart pump blood more efficiently. It is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. The doctor may closely monitor your blood pressure, heart rate, and ECG until you become stable. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Common side effects of this medicine include hypotension, headaches, arrhythmias, and tachycardia. Consult your doctor if these effects bother you. This medicine is used with caution for some people. Thus, you must inform the doctor if you are suffering from any kidney disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Side effects of Milicor Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Milicor Hypotension (low blood pressure) Headache Arrhythmia (irregular heartbeats) Tachycardia How to use Milicor Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Milicor Injection works Milicor 10mg Injection is a vasodilator. It increases the level of a chemical messenger (cAMP), which helps the smooth muscles to relax. Thus, dilates the blood vessels for better blood flow into the heart. It also has blood thinning property. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Milicor 10mg Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Milicor 10mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding SAFE IF PRESCRIBED Milicor 10mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. warnings Driving CONSULT YOUR DOCTOR It is not known whether Milicor 10mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. warnings Kidney CAUTION Milicor 10mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Milicor 10mg Injection may be needed. Please consult your doctor. warnings Liver SAFE IF PRESCRIBED Milicor 10mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Milicor 10mg Injection may not be needed in these patients. Please consult your doctor.

Nipress 50mg Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Nitroprusside (50mg) Storage Store below 30°C Uses of Nipress Injection Angina (heart-related chest pain) Heart Failure Coronary artery disease Hypertensive emergency Anal fissure Product introduction Nipress 50mg Injection is a medicine used in the immediate treatment of hypertensive emergency (severely increased blood pressure) and acute heart failure. It brings about an immediate reduction in blood pressure and the workload of the heart. Nipress 50mg Injection is given as a drip into the vein under the supervision of a doctor. Your doctor is the right person to decide the dose and duration, hence do not try to self-administered the injection at home. Regular monitoring of blood pressure is required while on treatment. Decreased blood pressure (hypotension) may occur as a side effect of this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding. It is also advisable to avoid medication like sildenafil or tadalafil while on treatment as it may cause a sudden lowering of blood pressure. Side effects of Nipress Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Nipress Cyanide poisoning Decreased blood pressure How to use Nipress Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Nipress Injection works Nipress 50mg Injection is a vasodilator. It works by relaxing the muscles in your blood vessels to help them widen and results in the lowering of blood pressure. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Nipress 50mg Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Nipress 50mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding CONSULT YOUR DOCTOR Nipress 50mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. warnings Driving CONSULT YOUR DOCTOR It is not known whether Nipress 50mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. warnings Kidney SAFE IF PRESCRIBED Nipress 50mg Injection is safe to use in patients with kidney disease. No dose adjustment of Nipress 50mg Injection is recommended. However, talk to your doctor if you have any underlying kidney disease.

Nitrocin 5ML Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Nitroglycerin (5mg/ml) Salt Synonyms Glyceryl Trinitrate Storage Store below 30°C Uses of Nitrocin Injection Angina (heart-related chest pain) Heart Failure Treatment of Hypertension (high blood pressure) Coronary artery disease Hypertensive emergency Anal fissure Product introduction Nitrocin 5mg Injection is used to treat and prevent heart-related chest pain (angina) and hypertension (high blood pressure) during surgery. This medicine works by relaxing and widening blood vessels so blood can flow more easily to the heart. It has a very short-lived effect. Nitrocin 5mg Injection is given as an injection under the supervision of a doctor with careful blood pressure monitoring. This is given as a continuous infusion into a vein and should not be stopped abruptly. It should not be mixed with any other medication of any kind. The most common side effect of Nitrocin 5mg Injection is a headache which may be severe. This can sometimes be helped by drinking plenty of fluids and avoiding alcohol. You may also experience lightheadedness, which could increase your risk of having a fall. There are other, rarer side effects, some of them serious. Ask your doctor and read the leaflet which comes with the medicine to make sure you are keeping safe. Do not use Nitrocin 5mg Injection if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or erectile dysfunction; or if you have anemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. It is best not to drink alcohol with this medicine as it increases some of the side effects. If you are affected by dizziness, avoid driving. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine. Benefits of Nitrocin Injection In Treatment of Hypertension (high blood pressure) Nitrocin 5mg Injection is used to treat hypertension in hypertensive emergencies. It rapidly dilates (widens) the blood vessels. This rapid vasodilation helps reduce blood pressure levels, relieving the strain on the heart and improving blood flow to vital organs. It is typically used in critical situations where immediate blood pressure reduction is necessary, such as severe high blood pressure that can lead to organ damage or other life-threatening complications. Side effects of Nitrocin Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Nitrocin Blurred vision Decreased blood pressure Dizziness Headache Increased heart rate Lightheadedness Paresthesia (tingling or pricking sensation) How to use Nitrocin Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Nitrocin Injection works Nitrocin 5mg Injection is a nitrate. It works by improving blood supply to heart and relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload, thereby preventing/treating attacks of angina (chest pain). Relaxation of blood vessels lowers blood pressure. Safety advice warnings Alcohol UNSAFE Consuming alcohol while taking Nitrocin 5mg Injection may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction). warnings Pregnancy SAFE IF PRESCRIBED Nitrocin 5mg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. warnings Breast feeding SAFE IF PRESCRIBED Nitrocin 5mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. warnings Driving UNSAFE Nitrocin 5mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. warnings Kidney SAFE IF PRESCRIBED Nitrocin 5mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nitrocin 5mg Injection may not be needed in these patients. Please consult your doctor. warnings Liver CONSULT YOUR DOCTOR There is limited information available on the use of Nitrocin 5mg Injection in patients with liver disease. Please consult your doctor.

Dopan 200mg Injection Salt Composition : Dopamine Hydrochloride Manufacturer : CELON LABORATORIES LTD Introduction to Dopan 200mg Injection Dopan 200mg injection contains the active ingredient Dopamine hydrochloride. It is used to treat low blood pressure and helps improve the muscle contraction strength in the heart. It also aids in improving low blood pressure due to open heart surgery, injury, congestive heart failure, heart attack, blood poisoning, and infection. Inform your doctor before using Dopan 200mg injection if you are pregnant or breastfeeding, if you have heart problems, liver or kidney problems, sulphite sensitivity, a tumor, narrow-angle glaucoma, diabetes, blood disorder, hyperthyroidism, or if you have been taking antidepressants. Headache, nausea and vomiting, palpitation, trouble breathing (dyspnoea), low blood pressure, and chest pain are common side effects seen with the use of Dopan 200mg injection. Uses of Dopan 200mg Injection In treating low blood pressure or shock due to heart attack, trauma, or injury In treating low blood pressure due to blood infections or blood poisoning To treat congestive heart failure In combination with other treatments to treat low blood pressure after open heart surgery. Therapeutic Effects of Dopan 200mg Injection Dopan 200mg injection works by producing an ionotropic effect on the muscles of the heart, which causes an increase in the strength of heart muscle contractions and heart rate. As a result of this, there is an increase in blood pressure and cardiac output. Interaction of Dopan 200mg Injection with other drugs Inform your healthcare professional about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications belong to Tricyclic antidepressant drugs, and interacting with Dopan 200mg injection may reduce effectiveness by causing undesirable side effects. More Information about Dopan 200mg Injection Keep Dopan 200mg injection out of the reach and sight of children. Do not store above 25°C. How to consume Dopan 200mg Injection Dopan 200mg injection is administered as an intravenous infusion into the vein. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person. Safety Advices for Dopan 200mg Injection Image Not Available Pregnancy If you are planning a pregnancy or think you may be pregnant, inform your doctor. Dopan 200mg injection might be unsafe during pregnancy because it can harm the unborn baby. Image Not Available Breast Feeding Inform your doctor in case you are breastfeeding since it is unknow whether Dopan 200mg injection is good for breast milk or not. Image Not Available Lungs It is unknown whether Dopan 200mg injection is safe for lung conditions. So consult your doctor in case you have any lung disease before starting the treatment. Image Not Available Liver Inform your doctor in case you have any liver diseases before starting treatment with Dopan 200mg injection. Image Not Available Alcohol It is unknown whether consuming alcohol while taking a Dopan 200 mg injection is safe. Please speak with your physician. Image Not Available Driving Instructions for driving are not applicable as Dopan 200mg injection is administered at the hospital. Side Effects of Dopan 200mg Injection Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

INTRODUCTION ABALAM 600/300 is a combination of Abacavir and Lamivudine which belongs to the group of medicines called Anti-viral agents. It is used in the management of HIV infection in adults, adolescents and in children (weighing above 25 kgs). HIV (human immunodeficiency virus) infection is a viral infection that damages our immune system and weakens our body’s ability to fight against various infections. Both abacavir and lamivudine are nucleoside reverse transcriptase inhibitors. They work by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. This prevents further multiplication of viral cells within the body. Also, they can improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. ABALAM 600/300 cannot not manage HIV infection completely. It can reduce only the number of viral cells present in the body and maintains them at a lower level. During management with ABALAM 600/300 your doctor will closely monitor your body weight, blood cholesterol levels and blood sugar levels to reduce the risk of unwanted side effects. Do not take ABALAM 600/300 if you are allergic to abacavir or lamivudine. Before taking ABALAM 600/300 inform your doctor if you have diabetes or any liver (hepatitis C or B infection), kidney or heart problems. If you are already taking ABALAM 600/300 to manage hepatitis B or C infection, do not stop taking it without consulting your doctor. Even if you take ABALAM 600/300, it is important for you to follow certain measures to prevent the spread of infections to the other people (such as avoid having unprotected sexual intercourse or sharing needles or personal items like toothbrush, razors etc with other people). ABALAM 600/300 is not recommended for use in pregnant or breastfeeding women. The most common side effects of taking ABALAM 600/300 are difficulty in sleeping, increased signs of infections, nausea, stomach pain, headache, or dizziness. Consult your doctor if any of these side effects worsens. Also inform your doctor immediately if you experience severe fever with extreme tiredness, sudden changes in body weight or severe stomach pain along with dark urine after taking ABALAM 600/300. USES OF ABALAM 600/300 Manages HIV infection in adults, adolescents and in children (weighing above 25 kgs) HOW ABALAM 600/300 WORKS ABALAM 600/300 is an anti-retroviral medicine. It controls the multiplication of viral cell within the body, by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. It can also improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. DIRECTIONS FOR USE Take ABALAM 600/300 as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. ABALAM 600/300 can be taken with or without meals. Your doctor will decide the correct dose and for how long ABALAM 600/300 must be taken depending upon your age, body weight and severity of the infection. Do not stop taking ABALAM 600/300 without consulting your doctor as it may reduce its effectiveness. SIDE EFFECTS OF ABALAM 600/300 COMMON difficulty in sleeping feeling depressed headache, tiredness, dizziness nausea, diarrhoea fever, skin rash stomach pain loss of appetite irritated or runny nose hair loss UNCOMMON decrease in RBC, WBC, and platelets RARE Stop taking ABALAM 600/300 and contact your doctor immediately if you experience any of the following side effects: signs of allergic reactions (such as skin rash, fever, accompanied with sore throat, cough, nausea, vomiting, stomach pain, diarrhea, tiredness, joint pain, muscle pain, swelling of the neck, difficulty in breathing, mouth ulcers, occasional headaches, inflammation of the eye, low blood pressure, sense of tingling or numbness of hands or feet) pure red cell aplasia (failure of bone marrow to produce new red blood cells) signs of infections (such as fever, headache, stomach-ache, breathing difficulty) signs of auto-immune disorders (such as rapid or irregular heartbeat, tremor, hyperactivity, general weakness) signs of osteonecrosis (death of bone cells causing joint stiffness, pain in the hip, knee or shoulder and difficulty in moving) signs of liver problems (such as yellowing of the skin and whites of the eye, dark urine, light-coloured stools, loss of appetite, nausea, pain, tenderness on the right side of stomach) heart attack changes in body fat (such as increase fat in the shoulder and neck (buffalo hump), breast, and in the middle body or fat loss from the legs, arms, or face)