Marketer Khandelwal Laboratories Pvt Ltd SALT COMPOSITION Methotrexate (50mg) Storage Store below 30°C Uses of Plastomet Injection Treatment of Cancer Product introduction Plastomet 50 Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy. Plastomet 50 Injection is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage. The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, mouth sores, and decreased white blood cells. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor will advise you regular blood tests to check for these. Before taking it, tell your doctor if have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine. Benefits of Plastomet Injection In Treatment of Cancer Plastomet 50 Injection belongs to a group of medicines called antimetabolites and is referred to as a cytotoxic. It works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated. Side effects of Plastomet Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Plastomet Abdominal pain Indigestion Loss of appetite Nausea Vomiting Tiredness Mouth sore Decreased white blood cell count How to use Plastomet Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Plastomet Injection works Plastomet 50 Injection is an anti-cancer medication. It works by blocking an enzyme (dihydrofolate reductase) involved in DNA synthesis in cancer cells. This slows the growth of cancer cells and eventually kills them. Safety advice warnings Alcohol CAUTION Caution is advised when consuming alcohol with Plastomet 50 Injection. Please consult your doctor. warnings Pregnancy UNSAFE Plastomet 50 Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby. warnings Breast feeding UNSAFE Plastomet 50 Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. warnings Driving UNSAFE Plastomet 50 Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. warnings Kidney CAUTION Plastomet 50 Injection should be used with caution in patients with kidney disease. Dose adjustment of Plastomet 50 Injection may be needed. Please consult your doctor. Regular monitoring of kidney function test is advised while you are taking this medicine. warnings Liver CAUTION Plastomet 50 Injection should be used with caution in patients with liver disease. Dose adjustment of Plastomet 50 Injection may be needed. Please consult your doctor. Use of Plastomet 50 Injection is not recommended in patients with severe liver disease.

Procitil Injection is a medication that contains Prochlorperazine, a phenothiazine class drug. It is primarily used to treat: 1. Severe Nausea and Vomiting Procitil is effective in managing nausea and vomiting caused by various conditions, including: • Post-operative recovery • Chemotherapy-induced nausea • Gastrointestinal disorders 2. Psychotic Disorders Prochlorperazine, the active ingredient in Procitil, has antipsychotic properties and is used to manage symptoms of: • Schizophrenia • Delirium • Severe anxiety 3. Vertigo and Dizziness It helps alleviate dizziness and balance issues associated with inner ear problems. 4. Severe Anxiety Procitil can be used in the short-term management of severe anxiety when other treatments are not effective. 5. Hiccups In some cases, Procitil is used to treat persistent and severe hiccups. Administration Procitil Injection is administered intravenously or intramuscularly by a healthcare professional. The dosage and frequency depend on the specific condition being treated and the patient's response to therapy. Side Effects Common side effects may include: • Drowsiness or sedation • Dizziness • Dry mouth • Constipation • Blurry vision • Muscle stiffness or tremors • Serious side effects are rare but can include: • Severe allergic reactions • Neuroleptic malignant syndrome (a life-threatening condition) • Tardive dyskinesia (involuntary movements) If you experience any unusual symptoms, contact your healthcare provider immediately. Precautions Before using Procitil Injection, inform your doctor if you have: • Allergies to prochlorperazine or other phenothiazines • Liver or kidney disease • Heart problems • Seizure disorders • Parkinson's disease • Pregnancy or breastfeeding status

Pipracan 4.5 Injection is a combination antibiotic medication containing Piperacillin (4 g) and Tazobactam (0.5 g). This formulation is used to treat a wide range of serious bacterial infections that may not respond to other antibiotics. ________________________________________ 🔹 Common Uses Pipracan 4.5 Injection is prescribed for: • Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) • Urinary tract infections (UTIs) • Intra-abdominal infections (e.g., peritonitis) • Skin and soft tissue infections, including diabetic foot infections • Gynecological infections, such as uterine infections • Bone and joint infections • Bloodstream infections (bacteremia) It is also used for prophylactic treatment in surgical procedures to prevent infections. ________________________________________ 🔹 How It Works • Piperacillin is a broad-spectrum penicillin antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death. • Tazobactam is a beta-lactamase inhibitor that protects piperacillin from degradation by beta-lactamase enzymes produced by certain bacteria, thereby enhancing its efficacy. This combination allows Pipracan 4.5 to target a wide array of bacteria, including those resistant to other antibiotics. ________________________________________ 🔹 Administration Pipracan 4.5 Injection is administered intravenously by a healthcare professional. The dosage and duration of treatment depend on the type and severity of the infection, as well as the patient's medical condition. Self-administration is not recommended. ________________________________________ 🔹 Side Effects Common side effects may include: • Nausea or vomiting • Diarrhea • Rash or itching • Pain, redness, or swelling at the injection site Serious side effects are rare but can include allergic reactions, liver enzyme abnormalities, or blood disorders. Seek immediate medical attention if you experience symptoms like difficulty breathing, swelling of the face or throat, or unusual bruising or bleeding. ________________________________________ 🔹 Precautions Before using Pipracan 4.5 Injection, inform your doctor if you have: Allergies to penicillins or beta-lactam antibiotics • Kidney or liver disease • A history of gastrointestinal diseases, such as colitis • Bleeding disorders • Undergoing dialysisUse during pregnancy and breastfeeding should be discussed with your healthcare provider. The medication should only be used if the potential benefits justify the potential risks.

Ondican 4 Injection, also known by the generic name Ondansetron 4 mg Injection, is an antiemetic medication primarily used to prevent and treat nausea and vomiting associated with various medical conditions and treatments. Common Uses 1. Chemotherapy-Induced Nausea and Vomiting (CINV): Ondican 4 is administered to prevent nausea and vomiting caused by chemotherapy. It is typically given 30 minutes before the start of chemotherapy sessions. 2. Radiation Therapy-Induced Nausea and Vomiting: It is used to prevent nausea and vomiting associated with radiation therapy, usually administered 1–2 hours before treatment. 3. Postoperative Nausea and Vomiting (PONV): Ondican 4 helps prevent and treat nausea and vomiting following surgery. It is administered immediately before or within 2 hours after surgery. 4. Other Causes of Nausea and Vomiting: It may also be used to manage nausea and vomiting due to other causes, such as gastroenteritis or certain medical conditions. Mechanism of Action Ondican 4 works by blocking the action of serotonin, a chemical in the body that can trigger nausea and vomiting. By inhibiting serotonin receptors in the brain and gastrointestinal tract, it effectively prevents these symptoms. Administration Ondican 4 Injection is administered intravenously (IV) by a healthcare professional in a hospital or clinic setting. The dosage and timing depend on the specific condition being treated and the patient's medical history. Side Effects Common side effects may include: • Headache • Constipation • Dizziness • Fatigue • Injection site reactions These side effects are generally mild and temporary. However, if they persist or worsen, consult your healthcare provider. Precautions Before receiving Ondican 4, inform your doctor if you have: • Liver disease • Heart problems • Electrolyte imbalances • Blockage in the stomach or intestines Additionally, disclose any other medications you are taking, as interactions may occur. Pregnant or breastfeeding individuals should consult their healthcare provider before use.

Milrican 10 is a brand of Milrinone Lactate Injection, manufactured by American Remedies. Milrinone is a phosphodiesterase-3 (PDE3) inhibitor that serves as both an inotropic agent and a vasodilator. ________________________________________ ✅ Primary Uses of Milrican 10 Milrican 10 is indicated for the short-term intravenous treatment of: • Severe congestive heart failure: Particularly in patients unresponsive to conventional therapies. • Acute decompensated heart failure: Including low output states following cardiac surgery. It is commonly used in intensive care units or during cardiac procedures to support heart function. ________________________________________ ⚙️ Mechanism of Action Milrinone works by inhibiting PDE3, leading to increased cyclic AMP (cAMP) levels in cardiac and vascular smooth muscle cells. This results in: • Increased myocardial contractility: Enhancing the heart's ability to pump blood. • Vasodilation: Relaxing blood vessels, which reduces the heart's workload and improves blood flow. ________________________________________ ⚠️ Important Considerations • Administration: Milrican 10 should only be administered intravenously under the supervision of a healthcare professional. • Monitoring: Patients receiving Milrican 10 require close monitoring of blood pressure, heart rate, and kidney function. • Contraindications: Not recommended for patients with severe dehydration, electrolyte imbalances, or known hypersensitivity to milrinone. • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.

Menacan K3 Injection is a brand name for Menadione Sodium Bisulphite Injection, which is a synthetic form of Vitamin K3. It is primarily used in medical and veterinary settings to address Vitamin K deficiencies and related conditions. ________________________________________ 💉 Medical Uses Menacan K3 Injection is indicated for: • Treatment of Vitamin K Deficiency: Essential for synthesizing clotting factors II, VII, IX, and X in the liver. A deficiency can lead to bleeding disorders. • Management of Hypoprothrombinemia: A condition characterized by low levels of prothrombin, increasing the risk of bleeding • Reversal of Anticoagulant Effects: Used in cases of anticoagulant overdose, particularly when rapid reversal is necessary. • Support in Liver Disease: Beneficial for patients with liver disease where vitamin K absorption is impaired. • Treatment of Malabsorption Syndromes: In patients with conditions that disrupt vitamin K absorption. ________________________________________ ⚠️ Important Considerations • Administration: Should only be administered by a trained healthcare professional. Self-administration is not recommended. • Contraindications: Not suitable for individuals with G6PD deficiency, as it can cause serious side effects. Also, use with caution in patients with liver or kidney disease, or those who are pregnant or breastfeeding. • Side Effects: May include facial flushing, sweating, injection site reactions, hemolysis, and altered taste. These side effects are generally mild and resolve over time.

Magsocan 50% Injection is a medicine used in the treatment of decreased magnesium levels in blood. It is also used for treatment of seizures in pregnant women who have high blood pressure. It widens the blood vessels in the brain and improves the blood supply to the nerve cells. Magsocan 50% Injection is generally administered by a healthcare professional in a hospital or clinical setting. You should not self-administer this medicine at home. Using of Magneon 50% Injection may cause redness, pain, and swelling at the site of injection. If these side effects persist or worsen, inform your doctor.

Actorise 100 Injection is used in the treatment of anemia that may have occurred due to chronic kidney disease or chemotherapy. It works by stimulating the bone marrow to produce more red blood cells. Actorise 100 Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional. It may cause side effects like high blood pressure and hypersensitivity. Inform your doctor if there are symptoms of very high blood pressure such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures). Your doctor may get your blood tests done regularly to monitor the levels of salts (electrolytes such as potassium), hemoglobin, and blood cells in your blood. You should stop taking it and consult with a doctor if you develop shortness of breath or skin rash.

Actorise 200 Injection is used in the treatment of anemia that may have occurred due to chronic kidney disease or chemotherapy. It works by stimulating the bone marrow to produce more red blood cells. Actorise 200 Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional. It may cause side effects like high blood pressure and hypersensitivity. Inform your doctor if there are symptoms of very high blood pressure such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).