Milrican 10 is a brand of Milrinone Lactate Injection, manufactured by American Remedies. Milrinone is a phosphodiesterase-3 (PDE3) inhibitor that serves as both an inotropic agent and a vasodilator. ________________________________________ ✅ Primary Uses of Milrican 10 Milrican 10 is indicated for the short-term intravenous treatment of: • Severe congestive heart failure: Particularly in patients unresponsive to conventional therapies. • Acute decompensated heart failure: Including low output states following cardiac surgery. It is commonly used in intensive care units or during cardiac procedures to support heart function. ________________________________________ ⚙️ Mechanism of Action Milrinone works by inhibiting PDE3, leading to increased cyclic AMP (cAMP) levels in cardiac and vascular smooth muscle cells. This results in: • Increased myocardial contractility: Enhancing the heart's ability to pump blood. • Vasodilation: Relaxing blood vessels, which reduces the heart's workload and improves blood flow. ________________________________________ ⚠️ Important Considerations • Administration: Milrican 10 should only be administered intravenously under the supervision of a healthcare professional. • Monitoring: Patients receiving Milrican 10 require close monitoring of blood pressure, heart rate, and kidney function. • Contraindications: Not recommended for patients with severe dehydration, electrolyte imbalances, or known hypersensitivity to milrinone. • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.

Milicor 10mg Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Milrinone (10mg) Storage Store below 30°C Uses of Milicor Injection Heart Failure Product introduction Milicor 10mg Injection is a medicine used for short-term treatment of heart failure. It is also used to treat patients with a poorly functioning heart after heart surgery. It makes the heart pump blood more efficiently. It is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. The doctor may closely monitor your blood pressure, heart rate, and ECG until you become stable. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Common side effects of this medicine include hypotension, headaches, arrhythmias, and tachycardia. Consult your doctor if these effects bother you. This medicine is used with caution for some people. Thus, you must inform the doctor if you are suffering from any kidney disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Side effects of Milicor Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Milicor Hypotension (low blood pressure) Headache Arrhythmia (irregular heartbeats) Tachycardia How to use Milicor Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Milicor Injection works Milicor 10mg Injection is a vasodilator. It increases the level of a chemical messenger (cAMP), which helps the smooth muscles to relax. Thus, dilates the blood vessels for better blood flow into the heart. It also has blood thinning property. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Milicor 10mg Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Milicor 10mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding SAFE IF PRESCRIBED Milicor 10mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. warnings Driving CONSULT YOUR DOCTOR It is not known whether Milicor 10mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. warnings Kidney CAUTION Milicor 10mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Milicor 10mg Injection may be needed. Please consult your doctor. warnings Liver SAFE IF PRESCRIBED Milicor 10mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Milicor 10mg Injection may not be needed in these patients. Please consult your doctor.

Nipress 50mg Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Nitroprusside (50mg) Storage Store below 30°C Uses of Nipress Injection Angina (heart-related chest pain) Heart Failure Coronary artery disease Hypertensive emergency Anal fissure Product introduction Nipress 50mg Injection is a medicine used in the immediate treatment of hypertensive emergency (severely increased blood pressure) and acute heart failure. It brings about an immediate reduction in blood pressure and the workload of the heart. Nipress 50mg Injection is given as a drip into the vein under the supervision of a doctor. Your doctor is the right person to decide the dose and duration, hence do not try to self-administered the injection at home. Regular monitoring of blood pressure is required while on treatment. Decreased blood pressure (hypotension) may occur as a side effect of this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding. It is also advisable to avoid medication like sildenafil or tadalafil while on treatment as it may cause a sudden lowering of blood pressure. Side effects of Nipress Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Nipress Cyanide poisoning Decreased blood pressure How to use Nipress Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Nipress Injection works Nipress 50mg Injection is a vasodilator. It works by relaxing the muscles in your blood vessels to help them widen and results in the lowering of blood pressure. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Nipress 50mg Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Nipress 50mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding CONSULT YOUR DOCTOR Nipress 50mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. warnings Driving CONSULT YOUR DOCTOR It is not known whether Nipress 50mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. warnings Kidney SAFE IF PRESCRIBED Nipress 50mg Injection is safe to use in patients with kidney disease. No dose adjustment of Nipress 50mg Injection is recommended. However, talk to your doctor if you have any underlying kidney disease.

Brilinta 90mg Tablet Marketer AstraZeneca SALT COMPOSITION Ticagrelor (90mg) Storage Store below 30°C Uses of Brilinta Tablet Heart attack Prevention of heart attack and stroke Unstable angina Product introduction Brilinta 90mg Tablet belongs to a group of medicines called antiplatelet or blood thinners. It reduces the formation of harmful blood clots in blood vessels, which helps to prevent heart attacks or strokes in people with heart disease. Brilinta 90mg Tablet is also used to treat people with a recent heart attack or severe heart-related chest pain (unstable angina) who have undergone stenting of the heart. It helps to prevent serious heart-related problems like having another heart attack, stroke, or formation of blood clots in stents in such people. Your doctor will also prescribe aspirin, another antiplatelet medicine, along with this medicine. Brilinta 90mg Tablet may be taken with or without food and should be taken regularly at the same time each day. It is important to keep taking it even if you feel well. If you stop taking this medicine, it may increase your chances of having another heart attack or stroke. The most common side effects of this medicine are dyspnea (breathlessness) and bleeding. If you cut or injure yourself, it may take longer than usual for the bleeding to stop. Such episodes of bleeding are usually mild and resolve on their own. Mild breathlessness caused by this medicine usually resolves on its own with continued treatment. Let your doctor know if bleeding persists or if the breathlessness worsens or does not go away. Brilinta 90mg Tablet is not suitable for some people. Do not take it if you are bleeding from anywhere in the body, such as a stomach ulcer or bleeding within the brain. It is also not recommended for people with liver diseases. Before using the medicine, inform your doctor of any such problems. Benefits of Brilinta Tablet In Prevention of heart attack and stroke Brilinta 90mg Tablet is an antiplatelet medicine or blood thinner. It prevents blood from clotting inside the veins and arteries, helping the blood flow freely around your body and preventing a heart attack or stroke (deep vein thrombosis or pulmonary embolism). To achieve maximum benefits, take this medicine regularly and make appropriate lifestyle changes. It is often prescribed with a low dose of aspirin, which also helps prevent blood from clotting. Side effects of Brilinta Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Brilinta Bleeding Breathlessness How to use Brilinta Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Brilinta 90mg Tablet may be taken with or without food, but it is better to take it at a fixed time. How Brilinta Tablet works Brilinta 90mg Tablet is an antiplatelet medication. It works by preventing platelets from sticking together, thereby decreasing the formation of harmful blood clots. This lowers the chance of heart attack or stroke. Safety advice warnings Alcohol CAUTION Caution is advised when consuming alcohol with Brilinta 90mg Tablet. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Brilinta 90mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding CONSULT YOUR DOCTOR Information regarding the use of Brilinta 90mg Tablet during breastfeeding is not available. Please consult your doctor. warnings Driving CONSULT YOUR DOCTOR It is not known whether Brilinta 90mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Dizziness, confusion, vertigo, and syncope have been reported in some patients. If you experience such symptoms, be cautious while driving or using machines. warnings Kidney SAFE IF PRESCRIBED Brilinta 90mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Brilinta 90mg Tablet is recommended. Limited information is available on the use of Brilinta 90mg Tablet in renal dialysis patients. warnings Liver SAFE IF PRESCRIBED Brilinta 90mg Tablet is safe to use in patients with liver disease. No dose adjustment of Brilinta 90mg Tablet is recommended. Use of Brilinta 90mg Tablet is not recommended in patients with severe liver disease.

Dobier S 50mg Injection Salt: Dobutamine (50mg) INTRODUCTION ABOUT DOBIER S 50MG INJECTION DOBIER S 50MG INJECTION contains Dobutamine which belongs to the group of medicines called Cardiac Stimulants. It is used to improve heart functions. It restores heartbeat and blood pressure to normal levels among patients undergoing open heart surgery and in patients having heart failure or any other severe heart conditions that reduces heart rate (such as shock or cardiomyopathies (enlargement of heart muscles)). It can also be used as an alternative to exercise during stress testing (a procedure used to detect heart problems). DOBIER S 50MG INJECTION is suitable for use both in adults and in children (including infants). Before receiving DOBIER S 50MG INJECTION inform your doctor if you have asthma or any other respiratory disorders. You must also inform your doctor if you have any allergic conditions or low blood volume as a precaution. DOBIER S 50MG INJECTION is not suitable for stress testing in patients having any heart or blood vessels disorders that hinder blood flow. It is also not recommended for use in pregnant and in breastfeeding women unless considered necessary by the physician. The most common side effects of receiving DOBIER S 50MG INJECTION are fast heartbeat, headache, high or low blood pressure, shortness of breath, inflammation at the injection site, nausea and urge to pass urine. Consult your doctor if any of these side effects worsens. USES OF DOBIER S 50MG INJECTION Improves heart functions by restoring normal heartbeat and blood pressure Manage heart failure Manage shock (cardiogenic or septic shock) Manage any heart conditions that may result in poor circulation around the body (such as cardiomyopathies, open heart surgery) Used as an alternative to exercise during stress testing HOW DOBIER S 50MG INJECTION WORKS DOBIER S 50MG INJECTION is a cardiac stimulant. It stimulates the heart and improves heart functions. It helps your heart to work more effectively by strengthening the pumping action of the heart. It also improves blood circulation around the body by expanding the blood vessels present all over the body. DIRECTIONS FOR USE DOBIER S 50MG INJECTION will be given only by a doctor or by a trained healthcare professional into the vein (intravenously). Your doctor will decide the correct dose, duration of therapy and site of administration for you depending upon your age, body weight and health condition. SIDE EFFECTS OF DOBIER S 50MG INJECTION COMMON increased heart rate chest pain abnormal heartbeat, palpitations high or low blood pressure narrowing of the blood vessels headache wheezing, shortness of breath increase in WBC count in blood increased bleeding tendency urge to pass urine nausea skin rash fever inflammation at the injection site HOW TO MANAGE SIDE EFFECTS Headache: Try to take rest. Apply a pain-relieving balm on your forehead. If the symptom does not improve, consult with your doctor. Nausea: Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens. Skin rash: Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens. Inflammation at the site of injection: Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor. WARNING & PRECAUTIONS PREGNANCY DOBIER S 50MG INJECTION is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before receiving this medicine if you are pregnant or think you may be pregnant or planning to have a baby. BREASTFEEDING DOBIER S 50MG INJECTION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving this medicine if you are breastfeeding. DRIVING AND USING MACHINES Do not drive or operate any machines if your ability is affected by DOBIER S 50MG INJECTION. ALLERGY Do not receive DOBIER S 50MG INJECTION if you are allergic to Dobutamine. LUNGS DOBIER S 50MG INJECTION should be used with caution in patients with asthma or any allergic or respiratory conditions. Therefore, consult your doctor before receiving it. HEART DISEASE DOBIER S 50MG INJECTION is not recommended for use in patients who have narrowing of blood vessels supplying the heart (coronary artery stenosis) or other heart disorders. It should be used with caution in patients with other heart problems (such as coronary artery disease, or acute heart failure). Therefore, consult your doctor before receiving it. OTHERS DOBIER S 50MG INJECTION is not recommended for use if you: have low blood volume (hypovolaemia) have any disorders in the blood vessels that hinders blood flow Before receiving DOBIER S 50MG INJECTION, inform your physician if you:

Actorise 25mg Injection – Uses Active Ingredient: Darbepoetin alfa (25 mcg) Main Uses: Anemia in Chronic Kidney Disease (CKD): Actorise 25 is used to treat anemia caused by reduced erythropoietin production in patients with kidney disease. It helps increase red blood cell count, improving oxygen levels and reducing symptoms like fatigue. Anemia from Chemotherapy: In cancer patients undergoing chemotherapy, Actorise helps manage anemia resulting from the suppression of red blood cell production. How It Works: Darbepoetin alfa is a man-made version of erythropoietin, a hormone that encourages the bone marrow to make more red blood cells. This increases hemoglobin levels and improves the body's ability to carry oxygen. Administration: Given by injection under the skin (subcutaneous) or into a vein (intravenous). Should be administered by a healthcare professional. Storage Instructions: Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep away from light. Precautions: Regular blood tests are needed to monitor hemoglobin levels and blood pressure. Not suitable for people with uncontrolled high blood pressure. Avoid if allergic to darbepoetin alfa or any similar medication.

INTRODUCTION ABALAM 600/300 is a combination of Abacavir and Lamivudine which belongs to the group of medicines called Anti-viral agents. It is used in the management of HIV infection in adults, adolescents and in children (weighing above 25 kgs). HIV (human immunodeficiency virus) infection is a viral infection that damages our immune system and weakens our body’s ability to fight against various infections. Both abacavir and lamivudine are nucleoside reverse transcriptase inhibitors. They work by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. This prevents further multiplication of viral cells within the body. Also, they can improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. ABALAM 600/300 cannot not manage HIV infection completely. It can reduce only the number of viral cells present in the body and maintains them at a lower level. During management with ABALAM 600/300 your doctor will closely monitor your body weight, blood cholesterol levels and blood sugar levels to reduce the risk of unwanted side effects. Do not take ABALAM 600/300 if you are allergic to abacavir or lamivudine. Before taking ABALAM 600/300 inform your doctor if you have diabetes or any liver (hepatitis C or B infection), kidney or heart problems. If you are already taking ABALAM 600/300 to manage hepatitis B or C infection, do not stop taking it without consulting your doctor. Even if you take ABALAM 600/300, it is important for you to follow certain measures to prevent the spread of infections to the other people (such as avoid having unprotected sexual intercourse or sharing needles or personal items like toothbrush, razors etc with other people). ABALAM 600/300 is not recommended for use in pregnant or breastfeeding women. The most common side effects of taking ABALAM 600/300 are difficulty in sleeping, increased signs of infections, nausea, stomach pain, headache, or dizziness. Consult your doctor if any of these side effects worsens. Also inform your doctor immediately if you experience severe fever with extreme tiredness, sudden changes in body weight or severe stomach pain along with dark urine after taking ABALAM 600/300. USES OF ABALAM 600/300 Manages HIV infection in adults, adolescents and in children (weighing above 25 kgs) HOW ABALAM 600/300 WORKS ABALAM 600/300 is an anti-retroviral medicine. It controls the multiplication of viral cell within the body, by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. It can also improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. DIRECTIONS FOR USE Take ABALAM 600/300 as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. ABALAM 600/300 can be taken with or without meals. Your doctor will decide the correct dose and for how long ABALAM 600/300 must be taken depending upon your age, body weight and severity of the infection. Do not stop taking ABALAM 600/300 without consulting your doctor as it may reduce its effectiveness. SIDE EFFECTS OF ABALAM 600/300 COMMON difficulty in sleeping feeling depressed headache, tiredness, dizziness nausea, diarrhoea fever, skin rash stomach pain loss of appetite irritated or runny nose hair loss UNCOMMON decrease in RBC, WBC, and platelets RARE Stop taking ABALAM 600/300 and contact your doctor immediately if you experience any of the following side effects: signs of allergic reactions (such as skin rash, fever, accompanied with sore throat, cough, nausea, vomiting, stomach pain, diarrhea, tiredness, joint pain, muscle pain, swelling of the neck, difficulty in breathing, mouth ulcers, occasional headaches, inflammation of the eye, low blood pressure, sense of tingling or numbness of hands or feet) pure red cell aplasia (failure of bone marrow to produce new red blood cells) signs of infections (such as fever, headache, stomach-ache, breathing difficulty) signs of auto-immune disorders (such as rapid or irregular heartbeat, tremor, hyperactivity, general weakness) signs of osteonecrosis (death of bone cells causing joint stiffness, pain in the hip, knee or shoulder and difficulty in moving) signs of liver problems (such as yellowing of the skin and whites of the eye, dark urine, light-coloured stools, loss of appetite, nausea, pain, tenderness on the right side of stomach) heart attack changes in body fat (such as increase fat in the shoulder and neck (buffalo hump), breast, and in the middle body or fat loss from the legs, arms, or face)

Introduction to Tafero 25mg Tablet Tafero 25mg Tablet is an antiviral medication containing the active constituent Tenofovir alafenamide. It is used to treat chronic hepatitis B virus (HBV) infection. Hepatitis B is an infection affecting the liver caused by the hepatitis B virus. Discuss with your doctor about the precautions needed to avoid infecting others. Tell your doctor if you have or have ever had kidney diseases, liver diseases, or HIV before taking Tafero 25mg Tablet. Administration of this medicine may lead to lactic acidosis (accumulation of excessive acid) and hepatomegaly (enlarged liver). It is not recommended for patients weighing less than 35 kg. This medicine contains lactose. Contact your doctor if you are intolerant to sugars before taking medicine. Tell your doctor if you are breastfeeding or pregnant before taking Tafero 25mg Tablet. Do not stop taking this medicine without your doctor’s advice, as it may worsen the condition. The safety and efficacy of this medication in pediatric patients may differ from those in adults. Dosage adjustments and careful monitoring may be necessary for children and the elderly. Uses of Tafero 25mg Tablet Tafero 25mg Tablet is used in the treatment of: Hepatitis B virus (HBV) infection Therapeutic Effects of Tafero 25mg Tablet Its therapeutic effect of Tafero 25mg Tablet involves reducing viral replication, lowering a viral load, preserving the immune system, and delaying disease progression in individuals with HIV-1 or HBV. Interaction of Tafero 25mg Tablet with other drugs Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Tafero 25mg Tablet, reducing effectiveness by causing undesirable side effects. More Information about Tafero 25mg Tablet Store at temprature between 20°C to 25°C (68°F to 77°F). Keep away from moisture, heat, and light. It should not be frozen. Keep it in its original packaging. Keep away from children and pets. How to consume Tafero 25mg Tablet To consume Tafero 25mg Tablet properly, follow your healthcare provider's instructions regarding dosage, frequency, and duration. Take it with or without food, swallowing the tablets or capsules with water. Adhere to the prescribed dosing schedule; do not alter the dosage without consulting your healthcare provider. Safety Advices for Tafero 25mg Tablet Image Not Available Pregnancy If you are pregnant or planning to become pregnant, it is crucial to consult with your healthcare provider before taking Tafero 25mg Tablet. Image Not Available Breast Feeding Tafero 25mg Tablet is excreted into human breast milk, but the potential risks to the infant are not well established. So it is better to consult a doctor before taking it. Image Not Available Lungs If you have a history of lung disease or are experiencing respiratory symptoms while taking, it is important to consult your healthcare provider for a thorough evaluation before taking Tafero 25mg Tablet. Image Not Available Liver The safety of Tafero 25mg Tablet in individuals with liver disease may depend on the specific type and severity of liver disease and other factors. It is important to consult with a healthcare provider Image Not Available Alcohol It is generally recommended to avoid excessive alcohol consumption while taking Tafero 25mg Tablet or any medication. Alcohol can interact with this medication and affect liver function. Image Not Available Driving People may experience side effects such as dizziness, drowsiness, or fatigue while taking Tafero 25mg Tablet. Suppose you experience any of these side effects or any other symptoms that may interfere with your ability to drive safely. In that case, avoid driving or operating heavy machinery. Side Effects of Tafero 25mg Tablet Tafero 25mg Tablet causes some side effects like all medications, although not everyone will experience them. Serious: Too much lactic acid in the blood (unusual weakness, muscle pain, cold hands and feet) Severe liver problems (yellow skin and eyes, tea-colored urine, light-colored stools, loss of appetite) Severe kidney problems Common: Nausea, vomiting Diarrhea Stomach pain, joint pain Rash, itching Feeling tired Headache, dizziness

Combinib 250mg Tablet is used in the treatment of breast cancer. It works by stopping or slowing down the growth of cancer cells. It is either used alone or in combination with some other medicine to cure advanced-stage breast cancer. Combinib 250mg Tablet should be taken on an empty stomach or an hour before or 2 hours after a meal. The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea, or vomiting. Your doctor may check your liver function before, during, and after treatment with this medicine. Before taking Combinib 250mg Tablet, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details. Uses of Combinib Tablet Pancreatic cancer Small cell lung cancer Liver cancer Kidney cancer Thyroid cancer Blood cancer (Chronic myeloid leukaemia) Gastrointestinal stromal tumour Cancer of colon and rectum Non-small cell lung cancer Soft tissue sarcoma Chronic idiopathic myelofibrosis Breast cancer Side effects of Combinib Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Combinib Abdominal pain Back pain Breathing problems Constipation Cough Diarrhea Fatigue Headache Hot flashes Increased bilirubin in the blood Insomnia (difficulty in sleeping) Joint pain Liver damage Loss of appetite Mucosal inflammation Nausea Pain in extremities Rash Stomatitis (Inflammation of the mouth) Vomiting Weakness Weight gain How to use Combinib Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combinib 250mg Tablet is to be taken empty stomach. How Combinib Tablet works Combinib 250mg Tablet is an anti-cancer medication. It works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which are responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Combinib 250mg Tablet. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Combinib 250mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor. warnings Breast feeding UNSAFE Combinib 250mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. warnings Driving UNSAFE Combinib 250mg Tablet may cause side effects which could affect your ability to drive. warnings Kidney CAUTION Combinib 250mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor. Limited information is available on the use of Combinib 250mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. warnings Liver CAUTION Combinib 250mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor. Limited information is available on the use of this medicine in patients with the severe liver disease.