Rituxirel 500mg injection contains the active constituent rituximab. It is used for several different disease conditions in adults. It is used alone or with other medications to treat non-hodgkin’s lymphoma (cancer affecting white blood cells called B-lymphocytes) and chronic lymphocytic leukemia (a most common form of cancer that affects B-cells). It is also indicated to treat moderate-to-severe rheumatoid arthritis (a type of disease where the immune system attacks the leukapheresis body cells of its own joints) in combination with methotrexate in adults. Other uses include granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels that mainly affects the lungs and kidneys) in adults and children 2 years of age and older. It is also used to treat moderate to severe pemphigus vulgaris (an autoimmune condition that causes painful blisters on the skin and lining of the mouth, throat, nose, and genitals.

INTRODUCTION ABOUT RITUXIREL 100 INJECTION RITUXIREL 100 INJECTION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals). It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). RITUXIREL 100 INJECTION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion). Before receiving RITUXIREL 100 INJECTION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. RITUXIREL 100 INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving RITUXIREL 100 INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with RITUXIREL 100 INJECTION. The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens. USES OF RITUXIREL 100 INJECTION It is used to manage: Blood cancer (Chronic lymphocytic leukaemia) Lymph cancer (Non-Hodgkin’s Lymphoma) Rheumatoid arthritis (joint pain and inflammation) Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals) HOW RITUXIREL 100 INJECTION WORKS RITUXIREL 100 INJECTION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases. DIRECTIONS FOR USE RITUXIREL 100 INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RITUXIREL 100 INJECTION COMMON increased infections (bacterial, viral or fungal) low RBC, WBC and platelet counts in blood nausea, vomiting, diarrhea, stomach pain, constipation, indigestion mouth ulcers hair loss fever, chills, pneumonia, shingles, cold, sinusitis thrush, urinary tract infection headache, dizziness, tiredness, weakness hepatitis B infection high blood sugar and cholesterol levels weight loss, lack of appetite numbness, tingling, pricking, burning sensation on the skin restlessness, problems in falling asleep, anxiety, depression flushing (skin redness) eye inflammation or watery eyes ringing sound in the ears, ear pain uneven or fast heart rate, high or low blood pressure shortness of breath, runny nose, nasal itching and repeated sneezing increased sweating, night sweats muscle pain, joint pain, back pain, neck pain pain while passing urine fungal foot infection (athlete’s foot) tremors (shakiness) swelling of the hands or ankles UNCOMMON blood clotting problems changes in taste slow heart rate chest tightness and lung problems RARE Contact your doctor immediately if you experience any of the following side effects: fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems) signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever)

INTRODUCTION ABOUT RITUXIREL 500MG INJECTION RITUXIREL 500MG INJECTION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals). It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). RITUXIREL 500MG INJECTION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion). Before receiving RITUXIREL 500MG INJECTION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. RITUXIREL 500MG INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving RITUXIREL 500MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with RITUXIREL 500MG INJECTION. The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens. USES OF RITUXIREL 500MG INJECTION It is used to manage: Blood cancer (Chronic lymphocytic leukaemia) Lymph cancer (Non-Hodgkin’s Lymphoma) Rheumatoid arthritis (joint pain and inflammation) Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals) HOW RITUXIREL 500MG INJECTION WORKS RITUXIREL 500MG INJECTION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases. DIRECTIONS FOR USE RITUXIREL 500MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RITUXIREL 500MG INJECTION COMMON increased infections (bacterial, viral or fungal) low RBC, WBC and platelet counts in blood nausea, vomiting, diarrhea, stomach pain, constipation, indigestion mouth ulcers hair loss fever, chills, pneumonia, shingles, cold, sinusitis thrush, urinary tract infection headache, dizziness, tiredness, weakness hepatitis B infection high blood sugar and cholesterol levels weight loss, lack of appetite numbness, tingling, pricking, burning sensation on the skin restlessness, problems in falling asleep, anxiety, depression flushing (skin redness) eye inflammation or watery eyes ringing sound in the ears, ear pain uneven or fast heart rate, high or low blood pressure shortness of breath, runny nose, nasal itching and repeated sneezing increased sweating, night sweats muscle pain, joint pain, back pain, neck pain pain while passing urine fungal foot infection (athlete’s foot) tremors (shakiness) swelling of the hands or ankles UNCOMMON blood clotting problems changes in taste slow heart rate chest tightness and lung problems RARE Contact your doctor immediately if you experience any of the following side effects: fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems) signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever) HOW TO MANAGE SIDE EFFECTS Constipation Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.

Reditux 100 Injection is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis. Reditux 100 Injection is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include headache, weakness, edema, infection, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with hepatitis B.

Enfiera 100mg Injection is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis. Enfiera 100mg Injection is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Enfiera 500mg Injection is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis. Enfiera 500mg Injection is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include headache, weakness, edema, infection, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with hepatitis B.

Rituxirel 100mg Injection is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis. Rituxirel 100mg Injection is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include headache, weakness, edema, infection, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with hepatitis B.

Reditux 500mg Injection is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis. Reditux 500mg Injection is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include headache, weakness, edema, infection, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with hepatitis B.

Maball 500mg Injection is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis. Maball 500mg Injection is given as an injection under the supervision of doctor. You must take it in a dose as advised by the doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include headache, weakness, edema, infection, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with hepatitis B.