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'inhibiting pde3 leading'

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General Medicine

Milrican 10 is a brand of Milrinone Lactate Injection, manufactured by American Remedies. Milrinone is a phosphodiesterase-3 (PDE3) inhibitor that serves as both an inotropic agent and a vasodilator. ________________________________________ ✅ Primary Uses of Milrican 10 Milrican 10 is indicated for the short-term intravenous treatment of: • Severe congestive heart failure: Particularly in patients unresponsive to conventional therapies. • Acute decompensated heart failure: Including low output states following cardiac surgery. It is commonly used in intensive care units or during cardiac procedures to support heart function. ________________________________________ ⚙️ Mechanism of Action Milrinone works by inhibiting PDE3, leading to increased cyclic AMP (cAMP) levels in cardiac and vascular smooth muscle cells. This results in: • Increased myocardial contractility: Enhancing the heart's ability to pump blood. • Vasodilation: Relaxing blood vessels, which reduces the heart's workload and improves blood flow. ________________________________________ ⚠️ Important Considerations • Administration: Milrican 10 should only be administered intravenously under the supervision of a healthcare professional. • Monitoring: Patients receiving Milrican 10 require close monitoring of blood pressure, heart rate, and kidney function. • Contraindications: Not recommended for patients with severe dehydration, electrolyte imbalances, or known hypersensitivity to milrinone. • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.

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Eye Care

Tobi-D (Tobramycin with Dexamethasone) Eye Drops is a prescription ophthalmic solution combining an antibiotic and a corticosteroid to treat specific bacterial eye infections accompanied by inflammation. ________________________________________ ✅ Primary Uses Tobi-D is primarily used for: • Bacterial Conjunctivitis: Infection of the conjunctiva (the membrane covering the white part of the eye and the inner surface of the eyelids). • Keratitis: Infection of the cornea. • Post-surgical Infections: Prophylactic treatment or management of infections following eye surgeries. It addresses both the infection and the inflammation associated with these conditions. ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye(s) every 4–6 hours, or as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Contraindications and Cautions • Contraindications: o Hypersensitivity to tobramycin, dexamethasone, or any component of the formulation. o Active viral infections of the eye, such as herpes simplex keratitis. o Untreated fungal or mycobacterial infections of the eye. • Cautions: o Use with caution in patients with a history of glaucoma, as corticosteroids can increase intraocular pressure. o Prolonged use may lead to cataract formation or secondary ocular infections. o Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. ________________________________________ 🧪 Mechanism of Action • Tobramycin: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, leading to bacterial cell death. • Dexamethasone: A corticosteroid that reduces inflammation by inhibiting the release of inflammatory mediators. Together, these components address both the infection and the inflammation associated with certain eye conditions.

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Eye Care

FZ-3 Eye-Ear Drops containing Fluconazole are primarily used to treat fungal infections of the eyes and ears. Fluconazole is an antifungal medication that works by inhibiting the growth of fungi. 🔹 Primary Uses Fungal Eye Infections (Ophthalmic Fungal Infections) Fluconazole in eye drop form is used to treat fungal infections of the eye, such as fungal keratitis or endophthalmitis, which can cause inflammation, pain, and potentially lead to vision loss if left untreated. Fungal Ear Infections (Otomycosis) FZ-3 can be used for treating fungal ear infections, also known as otomycosis, which is often caused by fungi like Aspergillus or Candida. Symptoms include itching, pain, and discharge from the ear canal. 🔹 How It Works Fluconazole is an antifungal agent that works by inhibiting the fungal enzyme lanosterol 14α-demethylase, which is involved in the synthesis of ergosterol, an essential component of the fungal cell membrane. By blocking this enzyme, fluconazole disrupts the fungal cell membrane, leading to fungal cell death or inhibition of growth. ⚠️ Common Side Effects Eye: Mild eye irritation or burning sensation upon application Blurred vision (temporary) Redness or stinging in the eyes Ear: Mild ear irritation Ear itching or discomfort after application Temporary hearing changes (rare) If any of these side effects persist or worsen, consult your healthcare provider. 🔹 Usage Tips Dosage: Typically, 1–2 drops are applied to the affected eye or ear 2–3 times daily, as prescribed by your doctor. Application Instructions: Wash your hands thoroughly before applying the drops. For the eyes: Tilt your head back and gently pull down the lower eyelid to form a pocket. Instill the prescribed number of drops and gently close your eye for a few seconds. For the ears: Tilt your head to one side, apply the drops into the ear canal, and gently massage the ear to help the drops penetrate. If you are using other medications for the eyes or ears, wait about 5 minutes between applying each medication. Contact Lenses: If you wear contact lenses, remove them before applying the drops to avoid any contamination. You can reinsert your lenses after 15 minutes. 🔹 Precautions Allergies: If you have a known allergy to fluconazole or other azole antifungals, do not use the drops. Pregnancy and Breastfeeding: Fluconazole should be used with caution in pregnancy, particularly during the first trimester. Always consult your doctor if you are pregnant or breastfeeding. Underlying Conditions: Inform your healthcare provider if you have any liver or kidney diseases, as these conditions may affect how the medication works in your body. Systemic Absorption: Although FZ-3 is used topically, there is a possibility of systemic absorption. Monitor for any systemic side effects, especially with prolonged use.

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Eye Care

Dorzopar Eye Drops containing Dorzolamide 2% are primarily used to lower intraocular pressure (IOP) in individuals with glaucoma or ocular hypertension (high eye pressure). Here's a detailed breakdown of its uses: 🔹 Primary Uses Open-Angle Glaucoma Dorzolamide is a carbonic anhydrase inhibitor that helps reduce the production of aqueous humor (the fluid inside the eye). By decreasing the amount of fluid produced, it lowers the intraocular pressure (IOP), which is important in treating open-angle glaucoma. Glaucoma is a condition where high eye pressure can damage the optic nerve and lead to vision loss. Ocular Hypertension Dorzopar is also used for the treatment of ocular hypertension, a condition in which the eye pressure is elevated but glaucoma has not yet developed. Lowering eye pressure helps prevent the progression to glaucoma. 🔹 How It Works Dorzolamide works by inhibiting the carbonic anhydrase enzyme in the eye. This enzyme is involved in the production of aqueous humor. By blocking this enzyme, Dorzolamide reduces the amount of fluid produced inside the eye, which in turn lowers the eye pressure. ⚠️ Common Side Effects Eye irritation, burning, or stinging upon application Blurred vision (temporary) Redness in the eyes or foreign body sensation Dry eyes or increased tear production Headaches or dizziness (in some cases) Taste disturbance (a bitter taste in the mouth) 🔹 Usage Tips Dosage: Typically, 1 drop in each affected eye, twice daily (morning and evening), or as prescribed by your healthcare provider. Application Instructions: Wash your hands thoroughly before applying the drops. Tilt your head back slightly and pull down your lower eyelid to form a small pocket. Place one drop in the pocket without touching the dropper tip to your eye. Gently close your eye and blink a few times to help spread the medication. If using other eye medications, wait 5–10 minutes between applications. Contact Lenses: Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them. 🔹 Precautions Kidney or Liver Problems: Since Dorzolamide is metabolized in the body, it should be used with caution in individuals with kidney or liver issues. Pregnancy and Breastfeeding: Consult your doctor before using this medication if you are pregnant or breastfeeding, as the safety of Dorzolamide during pregnancy or while breastfeeding has not been fully established. Eye Infections: Be cautious if you have an eye infection, as Dorzolamide may not be suitable for some active infections. Systemic Effects: While Dorzolamide is generally applied locally to the eye, some systemic absorption may occur, leading to side effects like metabolic acidosis (rare). It should be used cautiously in patients with a history of diabetes, kidney disease, or respiratory problems.

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Anti Cancer Medicine

Introduction to Lastet 100mg Injection Lastet 100mg injection is an anticancer drug with the ingredient Etoposide. It belongs to the medication class known as cytostatic. It is used to treat certain types of cancers such as testicular cancer, small-cell lung cancer, acute myeloid leukemia (blood cancer), tumor in the lymphatic system (Hodgkin’s lymphoma, non-Hodgkin’s lymphoma), and ovarian cancer in adults. Talk to your doctor if you had or currently having radiotherapy or chemotherapy. Report to your doctor if you have any infections or low levels of protein (albumin) in your blood. Lastet 100mg Injection should not be taken if you have recently been vaccinated with yellow fever or any live vaccines. Before starting treatment with this medicine, it is very important to tell your physician if you currently or previously had any medical conditions of kidney problems or liver disorders. Both women and men should use effective birth control during the treatment and at least 6 months after the last dose. In men, it is recommended not to father a child during and up to 6 months after the treatment. So it is advised to get suggestions about fertility concerns from your doctor. Administration of Lastet 100mg injection may cause a reduction in the level of blood cells and increase the risk of developing infections. So, your doctor may perform blood tests regularly to monitor your kidney and liver function. It is unknown whether it is safe to use on a child. Uses of Lastet 100mg Injection Testicular cancer Small-cell lung cancer Acute myeloid leukemia (blood cancer) Hodgkin’s lymphoma and non-Hodgkin’s lymphoma Ovarian cancer Therapeutic Effects of Lastet 100mg Injection Lastet 100mg works by inhibiting the activity of topoisomerase II (essential for cell replication) and DNA synthesis, which will prevent cancer cells from growing and multiplying, ultimately leading to cell death. Interaction of Lastet 100mg Injection with other drugs Inform your healthcare provider about all your medicines, including prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products. Certain medications such as Ciclosporin, Phenytoin, Phenobarbitone, Warfarin, Anthracyclines, Aspirin, and Fosphenytoin may interact with Lastet 100mg and reduce effectiveness by causing undesirable side effects. More Information about Lastet 100mg Injection Keep Lastet 100mg out of sight and reach of children. Store at a controlled room temperature between 15°C to 30°C. Store in the original package Do not refrigerate or freeze. How to consume Lastet 100mg Injection Lastet 100mg injection is administered as an intravenous infusion into the vein. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administrate. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person. Safety Advices for Lastet 100mg Injection Image Not Available Pregnancy Do not take this Lastet 100mg if you are pregnant because it may cause harm to the unborn baby. Consult your doctor before starting the treatment. Image Not Available Breast Feeding It is unsafe to breastfeed while taking Lastet 100mg because it can cause toxicity to the baby. Please consult your physician for more advice. Image Not Available Lungs Consult your doctor if you experience any lung-related symptoms like; shortness of breath or lung inflammation while taking a Lastet 100mg injection. Image Not Available Liver You need to tell your doctor if you have any liver disorders before taking Lastet 100mg Injection. Your doctor may perform blood tests regularly to monitor your condition. Consult your doctor for more information. Image Not Available Alcohol It is unknown if drinking alcohol while taking a Lastet 100mg injection is safe. Please speak with your physician. Image Not Available Driving Driving while taking a Lastet 100mg injection is unsafe because this medicine can cause tiredness, lightheadedness, or dizziness. Side Effects of Lastet 100mg Injection Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Serious Severe allergic reactions (swelling of tongue, or throat, breathing difficulties, rash, flushing, fast heartbeat) Irregular heartbeat (arrhythmia) Blood disorder Hepatotoxicity (damage to the liver) Acute leukemia Common Nausea, vomiting Loss of appetite Abdominal pain Constipation, diarrhea Changes in skin color Weakness Asthenia (feeling weak) Temporary hair loss High or low blood pressure Dizziness Redness of the skin Sore lips, throat, or mouth ulcers Word of Advice Discuss your fertility problem with the doctor since, in men, it is advised not to father a child during and after the 6 months of treatment. So it is advised to get suggestions about fertility concerns. Avoid planning for the pregnancy.

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Eye Care

Atropine Sulphate Eye Drops IP refers to atropine sulfate in its pharmaceutical grade form, used specifically for ocular (eye) treatments. 'IP' stands for Indian Pharmacopoeia, which is a set of standards for medicines in India, ensuring quality, safety, and efficacy. Uses of Atropine Sulphate Eye Drops IP: Pupil Dilation (Mydriasis): One of the most common uses of atropine eye drops is to dilate the pupil for diagnostic purposes, especially during an eye examination. The drops relax the muscles in the eye, allowing for better visibility of the retina and optic nerve. Treatment of Uveitis and Iritis: Atropine is frequently prescribed for conditions such as uveitis and iritis (inflammation of the iris). The medication helps relieve pain and inflammation and prevents the iris from sticking to the lens. This is important to avoid complications like synechiae (adhesions between the iris and lens). Cycloplegia: Cycloplegia is the paralysis of the ciliary muscle that controls focusing. Atropine is used to temporarily paralyze this muscle during eye exams to assess the retina or the overall refractive status of the eye. Prevention of Post-Surgical Complications: After certain eye surgeries, atropine can help in preventing the formation of adhesions between the iris and the lens, which can occur after surgery like cataract surgery. It aids in recovery and minimizes the risk of complications. Management of Myopia (Nearsightedness): In some cases, atropine drops have been used in research to slow the progression of myopia (nearsightedness) in children, though this is less common in routine practice. How It Works: Atropine is an anticholinergic drug that blocks the action of acetylcholine, a neurotransmitter involved in eye muscle contraction. By inhibiting the contraction of the pupil’s sphincter muscle and the ciliary muscle, atropine causes pupil dilation and paralysis of accommodation, allowing for eye relaxation and easier examination. Dosage: The dosage depends on the condition being treated. Typically, for eye exams, one or two drops are applied to each eye, and the effects (pupil dilation) usually last for several hours. For therapeutic use, your doctor will prescribe the frequency and duration based on the specific condition. Precautions: Side Effects: Common side effects include blurred vision, sensitivity to light (photophobia), and dry mouth. In some cases, you may experience increased intraocular pressure or tachycardia (rapid heart rate). Avoid Exposure to Bright Light: Since atropine causes pupil dilation, you may be more sensitive to light. It's advisable to wear sunglasses when outside in bright conditions. Do Not Drive: Due to blurred vision, avoid driving or operating heavy machinery until the effects wear off. Systemic Effects: Rarely, atropine can be absorbed into the bloodstream, leading to symptoms such as confusion, rapid heart rate, or dry skin. If you experience these symptoms, seek medical help immediately. Contraindications: Glaucoma: Atropine should be used with caution, or avoided, in individuals with narrow-angle glaucoma or other eye conditions that affect intraocular pressure. Pregnancy and Breastfeeding: While atropine is generally considered safe in therapeutic doses, it’s essential to consult your doctor if you are pregnant or breastfeeding before using the drops.

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General Medicine

Aone SB 1.5 gm Injection is a combination antibiotic manufactured by American Remedies. It contains Ceftriaxone (1000 mg) and Sulbactam (500 mg). Ceftriaxone is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis, leading to cell death. Sulbactam is a β-lactamase inhibitor that protects Ceftriaxone from degradation by β-lactamase-producing bacteria, thereby enhancing its effectiveness. ________________________________________ 🩺 Uses of Aone SB 1.5 gm Injection Aone SB 1.5 gm Injection is prescribed for the treatment of various bacterial infections, including: • Lower Respiratory Tract Infections: Such as pneumonia. • Urinary Tract Infections (UTIs): Including both complicated and uncomplicated UTIs. • Intra-abdominal Infections: Such as peritonitis. • Skin and Soft Tissue Infections: Including cellulitis and abscesses. • Bone and Joint Infections: Such as osteomyelitis and septic arthritis. • Septicemia: Bloodstream infections. • Meningitis: Infections of the brain and spinal cord membranes. • Pelvic Inflammatory Disease: Infections of the female reproductive organs. • Endocarditis: Infection of the heart valves. • Surgical Prophylaxis: To prevent infections during or after surgery. ________________________________________ 💊 How It Works Ceftriaxone works by inhibiting the synthesis of bacterial cell walls, leading to the destruction of the bacteria. Sulbactam enhances the activity of Ceftriaxone by inhibiting β-lactamase enzymes that can degrade Ceftriaxone, thereby extending its spectrum of activity against resistant bacteria. ________________________________________ ⚠️ Side Effects Common side effects may include: • Injection site reactions (pain, redness, or swelling). • Diarrhea. • Rash. • Increased liver enzymes. • Low blood platelets. • Changes in white blood cell counts. If any of these side effects persist or worsen, consult your healthcare provider promptly. ________________________________________ ⚠️ Precautions Before using Aone SB 1.5 gm Injection, inform your doctor if you: • Have a history of allergies to cephalosporin antibiotics. • Have liver or kidney disease. • Are pregnant, planning to become pregnant, or breastfeeding. • Are taking any other medications, including over-the-counter drugs and supplements. Your doctor will determine the appropriate dosage and duration of treatment based on your specific condition.

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General Medicine

Aone 2 gm Injection is an antibiotic medication manufactured by American Remedies. It contains Ceftriaxone, a third-generation cephalosporin antibiotic, and is used to treat a wide range of bacterial infections. ________________________________________ 🩺 Uses of Aone 2 gm Injection Aone 2 gm Injection is prescribed for the treatment of various bacterial infections, including: • Lower Respiratory Tract Infections: Such as pneumonia and bronchitis. • Urinary Tract Infections (UTIs): Both complicated and uncomplicated. • Meningitis: Infections of the brain and spinal cord. • Skin and Soft Tissue Infections: Including abscesses and cellulitis. • Bone and Joint Infections: Such as osteomyelitis and septic arthritis. • Bloodstream Infections (Bacteremia): Including sepsis. • Pelvic Inflammatory Disease: Infections of the female reproductive organs. • Gonorrhea: A sexually transmitted infection caused by Neisseria gonorrhoeae. • Surgical Prophylaxis: To prevent infections during or after surgery. ________________________________________ 💊 How It Works Ceftriaxone works by inhibiting the synthesis of bacterial cell walls, leading to the destruction of the bacteria. It is administered either intravenously (IV) or intramuscularly (IM) under the supervision of a healthcare professional. ________________________________________ ⚠️ Side Effects Common side effects may include: • Injection site reactions (pain, redness, or swelling). • Diarrhea. • Rash. • Changes in liver function tests. • Abnormal blood cell counts (e.g., decreased white blood cells or platelets). If any of these side effects persist or worsen, consult your healthcare provider promptly. ________________________________________ 💰 Price and Availability The price of Aone 2 gm Injection varies by retailer. For instance, it is available for ₹36.8 per injection on 1mg. Prices may differ based on location and pharmacy. ________________________________________ ⚠️ Precautions Before using Aone 2 gm Injection, inform your doctor if you: • Have a history of allergies to cephalosporin antibiotics. • Have liver or kidney disease. • Are pregnant, planning to become pregnant, or breastfeeding. • Are taking any other medications, including over-the-counter drugs and supplements. Your doctor will determine the appropriate dosage and duration of treatment based on your specific condition.

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General Medicine

Aone 1 gm Injection is an antibiotic medication manufactured by American Remedies. It contains Ceftriaxone, a third-generation cephalosporin antibiotic, and is used to treat a wide range of bacterial infections. ________________________________________ 🩺 Uses of Aone 1 gm Injection Aone 1 gm Injection is prescribed for the treatment of various bacterial infections, including: • Urinary Tract Infections (UTIs) • Pneumonia • Meningitis • Ear infections (Otitis media) • Abdominal infections • Bone and joint infections • Pelvic inflammatory disease • Bloodstream infections (Bacteremia) • Gonorrhea ________________________________________ 💊 How It Works Ceftriaxone works by inhibiting the synthesis of bacterial cell walls, leading to the destruction of the bacteria. It is administered either intravenously (IV) or intramuscularly (IM) under the supervision of a healthcare professional. ________________________________________ ⚠️ Side Effects Common side effects may include: • Injection site reactions (pain, redness, or swelling) • Diarrhea • Rash • Changes in liver function tests • Abnormal blood cell counts (e.g., decreased white blood cells or platelets) If any of these side effects persist or worsen, consult your healthcare provider promptly. ________________________________________ 💰 Price and Availability The price of Aone 1 gm Injection varies by retailer. For instance, it is available for ₹36.8 per injection on 1mg . Prices may differ based on location and pharmacy. ________________________________________ ⚠️ Precautions Before using Aone 1 gm Injection, inform your doctor if you: • Have a history of allergies to cephalosporin antibiotics • Have liver or kidney disease • Are pregnant, planning to become pregnant, or breastfeeding • Are taking any other medications, including over-the-counter drugs and supplements Your doctor will determine the appropriate dosage and duration of treatment based on your specific condition.

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