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General Medicine

Nor-ADR Injection is a brand of Noradrenaline (Norepinephrine) Bitartrate Injection, manufactured by American Remedies. It is primarily used in critical care settings to manage severe hypotension (low blood pressure) and shock. ________________________________________ ✅ Primary Uses Nor-ADR Injection is indicated for: • Septic Shock: A life-threatening condition caused by severe infection leading to dangerously low blood pressure. • Cardiogenic Shock: A state where the heart is unable to pump sufficient blood to meet the body's needs. Anaphylactic Shock: A severe allergic reaction causing a sudden drop in blood pressure. • Hypotension During Surgery or Trauma: To maintain adequate blood pressure during and after surgical procedures or traumatic events. • Cardiac Arrest: As an adjunct in the management of cardiac arrest to improve blood flow to vital organs. These indications are supported by clinical guidelines and pharmacological references. ________________________________________ ⚙️ Mechanism of Action Noradrenaline is a potent vasopressor that works by: Alpha-1 Adrenergic Receptor Activation: Causing vasoconstriction, which increases systemic vascular resistance and raises blood pressure. • Beta-1 Adrenergic Receptor Activation: Increasing heart rate and myocardial contractility, thereby enhancing cardiac output. This dual action helps restore blood pressure and improve perfusion to vital organs in shock states. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Administration: Should be administered intravenously under strict medical supervision, typically in an intensive care unit (ICU) setting. • Monitoring: Continuous monitoring of blood pressure and heart rate is essential during administration. • Contraindications: Should not be used in patients with mesenteric or peripheral vascular thrombosis unless absolutely necessary. Common Side Effects: • Hypertension (high blood pressure) • Headache Nausea • Anxiety • Dizziness Serious Side Effects: • Arrhythmias (irregular heartbeats) • Tissue necrosis at the injection site • Reduced renal perfusion leading to renal failure Immediate medical attention is required if any serious side effects occur.

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Dopacan Injection is a brand of Dopamine Hydrochloride, a potent vasopressor and inotropic agent used in critical care settings to manage various cardiovascular conditions. It is administered intravenously under medical supervision. ________________________________________ 🩺 Medical Uses Dopacan Injection is indicated for: • Shock Management: Including septic shock, cardiogenic shock, and hypovolemic shock. • Acute Heart Failure: To improve cardiac output and perfusion. • Severe Hypotension: Especially in patients unresponsive to volume resuscitation. • Renal Protection: To enhance renal blood flow and urine output in certain critically ill patients. Dopamine works by stimulating dopaminergic and beta-adrenergic receptors, leading to increased heart rate, contractility, and renal perfusion. At higher doses, it also stimulates alpha-adrenergic receptors, causing vasoconstriction and increased blood pressure. ________________________________________ ⚙️ Dosage and Administration Dopacan Injection is administered intravenously, with the dosage tailored to the patient's condition and response: • Low Dose (1–5 mcg/kg/min): Primarily stimulates dopaminergic receptors, increasing renal blood flow and urine output. • Medium Dose (5–15 mcg/kg/min): Stimulates beta-1 adrenergic receptors, enhancing heart rate and contractility. • High Dose (15–50 mcg/kg/min): Stimulates alpha-1 adrenergic receptors, leading to vasoconstriction and increased blood pressure. Continuous monitoring of blood pressure, heart rate, and urine output is essential during administration. ________________________________________ ⚠️ Precautions and Contraindications Before using Dopacan Injection, inform your healthcare provider if you have: • Allergies to dopamine or other components of the injection. • A history of heart rhythm disorders or coronary artery disease. • Pheochromocytoma (a rare tumor of the adrenal glands). • Diabetes, asthma, or sulfite allergies. • Circulatory disorders such as Raynaud's disease or Buerger's disease. • Recent use of monoamine oxidase inhibitors (MAOIs). This medication is typically administered by healthcare professionals in a clinical setting and is not intended for self-administration. ________________________________________ 💊 Side Effects Common side effects may include: • Palpitations or increased heart rate. • Nausea and vomiting. • Headache. • Difficulty breathing. • Gangrene (in rare cases, due to excessive vasoconstriction). Serious side effects are rare but can occur. Seek immediate medical attention if you experience symptoms like chest pain, shortness of breath, or signs of gastrointestinal bleeding.

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Pregafox 300 Capsules – Pregabalin 300mg Pregafox 300 Capsules – Trusted Pregabalin 300mg Exporter & Dropshipper Worldwide 📧 Email: exports@ernestpharmaceuticals.com 📲 WhatsApp: +91 94054 76170 – Message us today for the best export & dropshipping deal 🌐 Websites: www.ernestpharmaceuticals.com | www.ernestimpex.com Pregafox 300 Capsules – Pregabalin 300mg Product Name: Pregafox 300 Capsules Active Ingredient: Pregabalin 300mg Form: Hard Gelatin Capsule Pack Size: As per requirement (usually blister packs or bottles) Product Description: Pregafox 300 Capsules contain Pregabalin 300mg, an anticonvulsant and neuropathic pain reliever. Pregabalin works by calming overactive nerve signals in the brain, which helps reduce pain, seizures, and anxiety symptoms. It is widely prescribed for managing chronic nerve-related pain and certain anxiety disorders. Uses of Pregafox 300 Capsules: Treatment of neuropathic pain caused by diabetes, shingles, spinal cord injury, or nerve damage As an adjunct therapy for partial-onset seizures in epilepsy Management of fibromyalgia (widespread muscle pain and tenderness) Treatment of generalized anxiety disorder (GAD) in adults Key Benefits: Provides long-lasting relief from nerve pain Improves quality of sleep by reducing nighttime discomfort Helps in better control of seizures when used with other medications Effective in reducing muscle pain and anxiety symptoms Dosage & Administration: Usual recommended dose: as directed by a healthcare professional Taken orally with water, with or without food Dosage may vary depending on patient condition and medical advice Safety Information: Should be taken only under medical supervision Possible side effects: dizziness, drowsiness, blurred vision, weight gain, dry mouth Avoid alcohol consumption during treatment Not recommended in pregnancy or breastfeeding unless advised by a doctor Storage: Store in a cool, dry place away from direct sunlight Keep out of reach of children

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