Marketer Dr Reddy's Laboratories Ltd SALT COMPOSITION Darbepoetin alfa (500mcg) Storage Store in a refrigerator (2 - 8°C). Do not freeze. Uses of Cresp Injection Anemia due to chronic kidney disease Anemia due to cancer chemotherapy Product introduction Cresp 500 Injection is used in the treatment of anemia that may have occurred due to chronic kidney disease or chemotherapy. It works by stimulating the bone marrow to produce more red blood cells. Cresp 500 Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional. Common side effects include abdominal pain, high blood pressure, rash, injection site pain, breathlessness, cough, and peripheral edema. Inform your doctor if there are symptoms of very high blood pressure such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures). Your doctor may get your blood tests done regularly to monitor the levels of salts (electrolytes such as potassium), hemoglobin, and blood cells in your blood. You should stop taking it and consult with a doctor if you develop shortness of breath or skin rash. Before taking Cresp 500 Injection, tell your doctor if you have heart disease, high blood pressure, or have had a seizure or stroke. If you are pregnant or breastfeeding, or plan to become pregnant or breastfeed, consult your doctor to make sure it is safe for you. Side effects of Cresp Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Cresp Abdominal pain High blood pressure Rash Injection site pain Breathlessness Cough Peripheral edema Procedural hypotension (low blood pressure) Convulsion Thromboembolism How to use Cresp Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Cresp Injection works Cresp 500 Injection is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Cresp 500 Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Cresp 500 Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding CONSULT YOUR DOCTOR Cresp 500 Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. warnings Driving SAFE Cresp 500 Injection does not usually affect your ability to drive. warnings Kidney SAFE IF PRESCRIBED Cresp 500 Injection is safe to use in patients with kidney disease. No dose adjustment of Cresp 500 Injection is recommended.

Introduction to Xolnic 4mg Injection Xolnic 4mg contains the active substance Zoledronic Acid. It belongs to the group of substances called bisphosphonates. It is used to reduce the amount of calcium in the blood in adult patients where it is too high due to the presence of a tumor. Tumors can accelerate normal bone change in such a way that the release of calcium from bone is increased. This condition is known as tumor-induced hypercalcemia (TIH). It is also used to prevent bone complications in adult patients with multiple myeloma and bone metastases from solid tumors (spread of cancer from the primary site to the bone), in addition to standard cancer therapy. Xolnic 4mg is also indicated to prevent or treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause. It is also used to treat osteoporosis in men. It is used to treat Paget’s disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Other uses include treating or preventing osteoporosis in men and women taking glucocorticoids (a corticosteroid medication that may cause osteoporosis). Do not take this injection if you are allergic to zoledronic acid, another bisphosphonate, or any other ingredients of this medicine and if you are pregnant or breastfeeding. Before initiating the treatment, inform your physician if you have kidney or liver problems, bone diseases, pain, swelling, or jaw numbness. This medicine is not recommended for use in adolescents and children below the age of 18 years. Xolnic 4mg is not cancer chemotherapy and will not slow or stop the spread of cancer. However, it can be used to treat bone diseases in patients with cancer. Uses of Xolnic 4mg Injection Treat hypercalcemia of malignancy Multiple myeloma Bone metastases from solid tumors Osteoporosis in postmenopausal women Osteoporosis in men Paget’s disease of bone Therapeutic Effects of Xolnic 4mg Injection Xolnic 4mg primarily inhibits bone resorption. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood. Interaction of Xolnic 4mg Injection with other drugs Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications like aminoglycosides, loop diuretics, and nephrotoxic drugs may interact with Xolnic 4mg and reduce its effectiveness by causing undesirable side effects. More Information about Xolnic 4mg Injection Store Xolnic 4mg at room temperature (20°C to 25°C) keep the injection away from the reach of children and pets. If you have missed any dosing appointments, inform your doctor and schedule immediately. How to consume Xolnic 4mg Injection It should only be administered by a trained doctor or nurse. It will be given as a drip (infusion) into your vein. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors. Do not self-administer the medication. Safety Advices for Xolnic 4mg Injection Image Not Available Pregnancy Xolnic 4mg is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Image Not Available Breast Feeding Breastfeeding is not recommended in patients taking Xolnic 4mg because the medicine passes into the breast milk in small amounts and may harm your baby. Image Not Available Lungs It is unknown whether Xolnic 4mg can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment. Image Not Available Liver It is unknown whether Xolnic 4mg can be used in patients with liver disorders. Inform your physician if you have liver problems before initiating the therapy. Image Not Available Alcohol Caution is advised when consuming alcohol with Xolnic 4mg. Please consult your doctor. Image Not Available Driving It is unsafe to drive or operate heavy machinery after using Xolnic 4mg as this medicine causes drowsiness and sleepiness. Side Effects of Xolnic 4mg Injection Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Nausea, vomiting Fatigue Anemia Bone pain Constipation, diarrhea dyspnea, and fever Swelling in the legs and feet Decreased weight Abdominal pain Muscle pain Tiredness Serious Changes in heart rhythm Severe hypersensitivity skin reactions Decreased calcium levels Severe bone pain Severe kidney problems Unusual fractures of the bone

Atropine Sulphate Eye Drops IP refers to atropine sulfate in its pharmaceutical grade form, used specifically for ocular (eye) treatments. 'IP' stands for Indian Pharmacopoeia, which is a set of standards for medicines in India, ensuring quality, safety, and efficacy. Uses of Atropine Sulphate Eye Drops IP: Pupil Dilation (Mydriasis): One of the most common uses of atropine eye drops is to dilate the pupil for diagnostic purposes, especially during an eye examination. The drops relax the muscles in the eye, allowing for better visibility of the retina and optic nerve. Treatment of Uveitis and Iritis: Atropine is frequently prescribed for conditions such as uveitis and iritis (inflammation of the iris). The medication helps relieve pain and inflammation and prevents the iris from sticking to the lens. This is important to avoid complications like synechiae (adhesions between the iris and lens). Cycloplegia: Cycloplegia is the paralysis of the ciliary muscle that controls focusing. Atropine is used to temporarily paralyze this muscle during eye exams to assess the retina or the overall refractive status of the eye. Prevention of Post-Surgical Complications: After certain eye surgeries, atropine can help in preventing the formation of adhesions between the iris and the lens, which can occur after surgery like cataract surgery. It aids in recovery and minimizes the risk of complications. Management of Myopia (Nearsightedness): In some cases, atropine drops have been used in research to slow the progression of myopia (nearsightedness) in children, though this is less common in routine practice. How It Works: Atropine is an anticholinergic drug that blocks the action of acetylcholine, a neurotransmitter involved in eye muscle contraction. By inhibiting the contraction of the pupil’s sphincter muscle and the ciliary muscle, atropine causes pupil dilation and paralysis of accommodation, allowing for eye relaxation and easier examination. Dosage: The dosage depends on the condition being treated. Typically, for eye exams, one or two drops are applied to each eye, and the effects (pupil dilation) usually last for several hours. For therapeutic use, your doctor will prescribe the frequency and duration based on the specific condition. Precautions: Side Effects: Common side effects include blurred vision, sensitivity to light (photophobia), and dry mouth. In some cases, you may experience increased intraocular pressure or tachycardia (rapid heart rate). Avoid Exposure to Bright Light: Since atropine causes pupil dilation, you may be more sensitive to light. It's advisable to wear sunglasses when outside in bright conditions. Do Not Drive: Due to blurred vision, avoid driving or operating heavy machinery until the effects wear off. Systemic Effects: Rarely, atropine can be absorbed into the bloodstream, leading to symptoms such as confusion, rapid heart rate, or dry skin. If you experience these symptoms, seek medical help immediately. Contraindications: Glaucoma: Atropine should be used with caution, or avoided, in individuals with narrow-angle glaucoma or other eye conditions that affect intraocular pressure. Pregnancy and Breastfeeding: While atropine is generally considered safe in therapeutic doses, it’s essential to consult your doctor if you are pregnant or breastfeeding before using the drops.

Victoza Solution for Injection is a medicine used to lower blood sugar levels in adults with type 2 diabetes mellitus. This helps to prevent serious complications of diabetes like kidney damage and blindness. Proper control of diabetes also helps to lower your chances of a heart attack or a stroke. Victoza Solution for Injection belongs to the GLP-1 (glucagon-like peptide) group of diabetes medicines. It works by helping your body produce insulin and by reducing appetite. It also helps to reduce weight in some people. This medicine should be stored in a refrigerator until you need it but do not freeze it. It is normally injected under the skin once daily. The dose will depend on your condition and what other diabetes medicines you are taking. You can use it at any time of the day with or without food but try to use it at the same time each day to get the most benefit. Your doctor or nurse will show you how and where to inject the medicine. Follow the instructions carefully. Do not stop taking this medicine without talking to your doctor. If you do, your blood sugar levels may increase and put you at risk of serious complications. Remember that it is only part of a treatment program that should also include a healthy diet and regular exercise as advised by your doctor. Your lifestyle plays a big part in controlling diabetes. The most common side effects of this medicine include nausea, diarrhea, vomiting, decreased appetite, indigestion, and constipation. It can also lead to low blood sugar levels (hypoglycemia) especially if you are also taking other medicines like insulin or sulphonylureas for treatment of diabetes. To prevent this, it is important to have regular meals and always carry a fast-acting source of glucose such as sugary candy or glucose candy with you. Before using it, let your doctor know if you have any pancreas or stomach problems or severe dehydration (loss of body water), or diabetic ketoacidosis (a complication of diabetes characterized by too much acid and ketones in your blood). This medicine may not be suitable. Pregnant or breastfeeding women should also consult their doctor before using this medicine. If you experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar, do not drive, use machinery or do any activity that requires alertness or clear vision until you are sure you can do them safely. Uses of Victoza Solution for Injection Type 2 diabetes mellitus

Taurians contains 2 potent anti-oxidants – N-acetyl cysteine & Taurine. Taurine is an amino acid that both dogs and cats require for good health. For cats, taurine is necessary for brain, nerves, eyes, heart, digestion, immune function and fetal development. For dogs, taurine is needed for eyes, reproduction, bile acid (for fat digestion) and for healthy heart. N-Acetylcysteine is useful in treating conditions that involve tissue damage due to oxidative stress and toxicity, Taurians helps to protect against damage from oxidative stress in patients with chronic kidney disease, reduces risk of cardiovascular disease, promotes healthy liver, prevents or reduces glomerular damage due to diabetes, and promotes clean & healthy lungs.

Oscinap is a combination of N-Acetyl Carnosine (NAC) & Sodium Carboxymethyl celulose (SCMC). Oscinap strengthens eye’s defence against free radicals and prrevents progression of cataracts in cats & dogs. N-Acetyl Carnosine penetrates the eye and gets further metabolized to form L-carnosine, an anti-glycating agent and oxidative stress reducer. When used with SCMC, NAC provides “sustained” action, SCMC is a eye lubricant and muco-adhesive provides temporary relief from burning and discomfort due to the eye’s dryness and acts as a protectant against further irritation.

Felintra contains Itraconazole, an anti-fungal with broad spectrum of activity and high safety margin against yeast and fungus. It has superior antifungal potency & fungicidal activity due to enhanced tissue penetration & residual effect. Felintra is indicated for use in dermatophytosis caused by M. canis in cats.

Tropind (Tropicamide 1%) Ophthalmic Solution is commonly used for the following purposes: Pupillary Dilation (Mydriasis): Tropind is often used by eye care professionals to dilate the pupils during eye exams, such as fundoscopy or slit-lamp examinations. It helps them get a clear view of the retina, optic nerve, and other structures inside the eye. Cycloplegia: Tropind is used to temporarily paralyze the ciliary muscle in the eye, which controls the lens's focusing ability. This is useful during certain types of eye exams, such as refraction tests, to evaluate the eye's refractive error without interference from accommodation (focusing). Treatment of Certain Eye Conditions: It may also be used to treat or manage certain eye conditions, such as uveitis (inflammation of the middle layer of the eye), to relieve pain and prevent further spasms of the eye muscles. How it works: Tropind contains tropicamide, which is an anticholinergic agent that works by blocking the action of acetylcholine on the muscles of the iris (pupil) and the ciliary body, causing pupil dilation and paralysis of accommodation. Administration: It is usually instilled directly into the eye as drops. The effects typically last for a few hours, depending on the individual and the purpose of use. Side effects: Potential side effects may include temporary blurry vision, sensitivity to light (due to pupil dilation), or stinging when the drops are first applied. Always follow the instructions provided by your healthcare provider or the product label when using Tropind.

Biotrav (Travoprost) Ophthalmic Solution Biotrav is a prescription eye drop containing travoprost, a prostaglandin analog used to lower intraocular pressure (IOP) in individuals with open-angle glaucoma or ocular hypertension. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common type of glaucoma characterized by gradual loss of vision due to increased IOP. • Ocular Hypertension: Elevated IOP without optic nerve damage, which can lead to glaucoma if untreated. ________________________________________ 💊 Dosage and Administration • Recommended Dosage: Instill one drop into the affected eye(s) once daily in the evening. • Application Tips: o Wash hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to travoprost or any component of the formulation. o Active or suspected ocular infections. o History of hypersensitivity to prostaglandin analogs. • Cautions: o Use with caution in patients with a history of uveitis, macular edema, or retinal vein occlusion. o May cause changes in eye color, eyelash growth, and skin pigmentation around the eyes. o Consult a healthcare provider before use if pregnant, planning to become pregnant, or breastfeeding. ________________________________________ 🧪 Mechanism of Action Travoprost works by increasing the outflow of aqueous humor through the trabecular meshwork and uveoscleral pathways, thereby reducing IOP. This helps prevent damage to the optic nerve and loss of vision associated with glaucoma and ocular hypertension.