Introduction to Ledifos Tablet Ledifos Tablet is a medicine that contains the active substances ledipasvir and sofosbuvir. It is indicated to treat chronic (long-term) hepatitis C virus infection in adults and children three years of age and older. Hepatitis C is a virus that mainly infects the liver. It is mainly triggered by a virus named Flavivirus. Most patients remain asymptomatic, and the symptoms show up only when they develop chronic liver disease or cirrhosis. The progression of liver disease is faster in people who consume alcohol and those with a weak immune system. The main treatment goal for Hepatitis C infection is complete eradication of the virus causing this infection. This drug is contraindicated for individuals with decompensated cirrhosis or severe liver disease. In such cases, alternative treatment options should be considered. This drug should not be used if you have any known allergy or hypersensitivity to Ledifos Tablet or other ingredients in the medication. Your liver function may change with the treatment of hepatitis C and, therefore, affect other medications (e.g., medicines used to suppress your immune system, etc.). Your doctor may need to monitor your other medicines and make dose adjustments closely. If you have liver disease other than hepatitis C, are awaiting a liver transplant, have a current or previous infection with the hepatitis B virus (HBV), or receive ongoing treatment for HIV infection. It's important to inform your doctor. They will consider these conditions before starting treatment. Talk to your doctor immediately before taking this drug if you have diabetes. You may need closer monitoring of your blood glucose levels or adjustment of your diabetes medication after starting this drug. Some diabetic patients have experienced low sugar levels in the blood (hypoglycemia) after starting treatment with medicines like Ledifos Tablet. The doctor will test your blood before, during, and after your treatment with this medicine. So that your doctor can confirm that your treatment has worked and you are free of the hepatitis C virus, do not breastfeed during treatment with this tablet. It is unknown whether this drug passes into human breast milk. Consult your doctor if you are breastfeeding. Do not give this tablet to children under three years of age. The use of this drug has not yet been studied. This tablet can interact with certain medications, potentially affecting their efficacy or increasing the risk of side effects. It's necessary to inform your doctor about all your medications, including prescription, over-the-counter, and herbal supplements, to ensure no potential interactions. Uses of Ledifos Tablet Chronic Hepatitis C virus infection. Therapeutic Effects of Ledifos Tablet The active substances in the Ledifos Tablet work together by blocking two different proteins that the virus needs to grow and reproduce itself, allowing the infection to be permanently eliminated from the body Interaction of Ledifos Tablet with other drugs Inform your doctor about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications, including rifampicin, rifabutin, St. John's wort, carbamazepine, phenobarbital, phenytoin, and rosuvastatin, may interact with Ledifos Tablet reducing effectiveness by causing undesirable side effects. More Information about Ledifos Tablet Store the Ledifos Tablet at a controlled room temperature of (30°C). Keep it out of reach of children. How to consume Ledifos Tablet It is an orally available prescription drug. Your doctor will decide the dose and duration of Ledifos Tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet with or without food. Do not break, chew, or crush the tablet. Swallow the whole tablet with water. Safety Advices for Ledifos Tablet Image Not Available Pregnancy The effects of this tablet during pregnancy are not known. If you are pregnant or plan to have a baby, consult your doctor before taking Ledifos Tablet. Image Not Available Breast Feeding Do not breastfeed during treatment with Ledifos Tablet. It is unknown whether this drug passes into human breast milk. Consult your doctor if you are breastfeeding. Image Not Available Lungs Patients with pre-existing lung disease should consult a healthcare provider before taking Ledifos Tablet. Image Not Available Liver Ledifos Tablet should be cautiously administered in patients with liver diseases. Dose adjustments are necessary. However, inform your physician of any liver diseases before initiating the therapy. Image Not Available Alcohol It is unknown whether alcohol may interact with Ledifos Tablet. Inform your physician if you drink alcoholic beverages. I

Nor-ADR Injection is a brand of Noradrenaline (Norepinephrine) Bitartrate Injection, manufactured by American Remedies. It is primarily used in critical care settings to manage severe hypotension (low blood pressure) and shock. ________________________________________ ✅ Primary Uses Nor-ADR Injection is indicated for: • Septic Shock: A life-threatening condition caused by severe infection leading to dangerously low blood pressure. • Cardiogenic Shock: A state where the heart is unable to pump sufficient blood to meet the body's needs. Anaphylactic Shock: A severe allergic reaction causing a sudden drop in blood pressure. • Hypotension During Surgery or Trauma: To maintain adequate blood pressure during and after surgical procedures or traumatic events. • Cardiac Arrest: As an adjunct in the management of cardiac arrest to improve blood flow to vital organs. These indications are supported by clinical guidelines and pharmacological references. ________________________________________ ⚙️ Mechanism of Action Noradrenaline is a potent vasopressor that works by: Alpha-1 Adrenergic Receptor Activation: Causing vasoconstriction, which increases systemic vascular resistance and raises blood pressure. • Beta-1 Adrenergic Receptor Activation: Increasing heart rate and myocardial contractility, thereby enhancing cardiac output. This dual action helps restore blood pressure and improve perfusion to vital organs in shock states. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Administration: Should be administered intravenously under strict medical supervision, typically in an intensive care unit (ICU) setting. • Monitoring: Continuous monitoring of blood pressure and heart rate is essential during administration. • Contraindications: Should not be used in patients with mesenteric or peripheral vascular thrombosis unless absolutely necessary. Common Side Effects: • Hypertension (high blood pressure) • Headache Nausea • Anxiety • Dizziness Serious Side Effects: • Arrhythmias (irregular heartbeats) • Tissue necrosis at the injection site • Reduced renal perfusion leading to renal failure Immediate medical attention is required if any serious side effects occur.

Nitrocan 25 Injection is a brand of Nitroglycerin Injection 25 mg/5 mL, manufactured by American Remedies. It is primarily used in hospital settings for the management of certain cardiovascular conditions. ________________________________________ ✅ Primary Uses Nitrocan 25 Injection is indicated for: • Angina Pectoris: To treat and prevent chest pain caused by reduced blood flow to the heart. • Acute Myocardial Infarction (Heart Attack): To alleviate chest pain and improve blood flow to the heart muscle. Hypertension During Surgery: To control high blood pressure during and after surgical procedures. • Congestive Heart Failure: To reduce the workload on the heart and improve symptoms. ________________________________________ ⚙️ Mechanism of Action Nitroglycerin is a nitrate that, once administered, is converted into nitric oxide in the body. This leads to the relaxation and dilation of blood vessels, improving blood flow and reducing the heart's workload. ________________________________________ ⚠️ Precautions • Contraindications: Should not be used in patients with severe anemia, hypotension, or those taking medications for erectile dysfunction (e.g., sildenafil, tadalafil) due to the risk of a significant drop in blood pressure. • Monitoring: Requires careful monitoring of blood pressure and heart rate during administration. • Administration: Administered intravenously under medical supervision; dosage and duration are determined by the healthcare provider. ________________________________________ 💊 Common Side Effects • Headache • Dizziness or lightheadedness • Hypotension (low blood pressure) • Nausea or vomiting • Flushing

Mucanix Injection is a brand of Acetylcysteine Injection, manufactured by American Remedies. Acetylcysteine is a mucolytic agent that helps in thinning and loosening mucus in the airways, making it easier to cough up and clear the airways. ________________________________________ ✅ Primary Uses Mucanix Injection is primarily used for: • Respiratory Disorders: Conditions such as chronic bronchitis, asthma, and cystic fibrosis, where there is excessive mucus production. • Paracetamol (Acetaminophen) Overdose: As an antidote to prevent liver damage when administered within 8 hours of overdose. ________________________________________ ⚙️ Mechanism of Action Acetylcysteine works by: • Breaking down mucus: It reduces the viscosity of mucus, facilitating easier expectoration. • Restoring glutathione levels: In cases of paracetamol overdose, it replenishes glutathione, a vital antioxidant, aiding in detoxification and protecting the liver. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Allergy: Do not use if allergic to acetylcysteine or any of its components. • Asthma: Use with caution in patients with asthma; monitoring is required. • Pregnancy and Breastfeeding: Consult a doctor before use during pregnancy or breastfeeding. Common Side Effects: • Nausea • Vomiting • Rash • Fever • Headache Serious Side Effects: • Anaphylactic reactions (rare) • Hypotension • Tachycardia If you experience any of these serious side effects, seek immediate medical attention.

Milrican 10 is a brand of Milrinone Lactate Injection, manufactured by American Remedies. Milrinone is a phosphodiesterase-3 (PDE3) inhibitor that serves as both an inotropic agent and a vasodilator. ________________________________________ ✅ Primary Uses of Milrican 10 Milrican 10 is indicated for the short-term intravenous treatment of: • Severe congestive heart failure: Particularly in patients unresponsive to conventional therapies. • Acute decompensated heart failure: Including low output states following cardiac surgery. It is commonly used in intensive care units or during cardiac procedures to support heart function. ________________________________________ ⚙️ Mechanism of Action Milrinone works by inhibiting PDE3, leading to increased cyclic AMP (cAMP) levels in cardiac and vascular smooth muscle cells. This results in: • Increased myocardial contractility: Enhancing the heart's ability to pump blood. • Vasodilation: Relaxing blood vessels, which reduces the heart's workload and improves blood flow. ________________________________________ ⚠️ Important Considerations • Administration: Milrican 10 should only be administered intravenously under the supervision of a healthcare professional. • Monitoring: Patients receiving Milrican 10 require close monitoring of blood pressure, heart rate, and kidney function. • Contraindications: Not recommended for patients with severe dehydration, electrolyte imbalances, or known hypersensitivity to milrinone. • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.

Esocard 100mg Injection belongs to a group of medicines called beta-blockers. It is used to treat emergency high blood pressure (hypertension), angina (heart-related chest pain), irregular heart rhythms (arrhythmia). Esocard 100mg Injection is administered under the supervision of a doctor or nurse. You should not self-administer this medicine at home. The dose and frequency depend on what you are taking it for and the severity of your condition. It is generally given along with continuous monitoring of blood pressure and heart rate. The main side effects of this medicine are fatigue, headache, slow heart rate, feeling dizzy, and nausea. These are usually mild and short-lived. It may also cause shortness of breath or low blood pressure in some people. To reduce the risk of side effects your doctor will probably start the medicine at a low dose and gradually increase it. Consult your doctor if the side effects bother you or do not go away.

Aplazar Tablet is a nutritional supplement used in the treatment of chronic kidney disease. It reduces urea levels in the blood and helps prevent the progression of kidney disease. This way it delays the risk of undergoing long-term dialysis. Aplazar Tablet is to be taken by mouth with or without food. Take it in the exact dose and duration as advised by the doctor. Taking it along with a low-protein diet may help get the best of the medicine. Ensure that you maintain adequate calorie intake during treatment. While you are taking this medicine, your doctor may advise regular monitoring of serum calcium levels. This medicine is usually well tolerated with no common side effects. Ensure regular doctor consultation to evaluate medicine effects on your body. Before taking Aplazar Tablet, it is important to tell your doctor if you are taking any other medicines for other health conditions.

Renhold tablet is a nutrient supplement with an active ingredient called Alpha Ketoanalogue. It belongs to the class of medicine called amino acids. It is given along with a protein-restricted diet to delay the progression of chronic kidney disease (CKD). It reduces uraemic symptoms (caused by the accumulation of nitrogenous waste compounds normally eliminated by the kidneys), improves nutritional status, and reduces metabolic complications in CKD patients. It works by lowering urea levels in the bloodstream and slowing down the advancement of kidney disease, thereby delaying the need for long-term dialysis. Do not consume Renhold tablet if you are allergic to Alpha Ketoanalogue or any of its ingredients. Avoid consuming this medicine if you have hypercalcemia (high level of calcium) or abnormal heartbeats; because the administration of this medicine may cause increased calcium levels in the blood and irregular heartbeats. During treatment, your doctor may recommend periodic monitoring of your serum calcium levels. Notifying your doctor if you are pregnant and breastfeeding before taking this medicine.

Ketoalfa Tablet is a nutritional supplement used in the treatment of chronic kidney disease. It reduces urea levels in the blood and helps prevent the progression of kidney disease. This way it delays the risk of undergoing long-term dialysis. Ketoalfa Tablet is to be taken by mouth with or without food. Take it in the exact dose and duration as advised by the doctor. Taking it along with a low-protein diet may help get the best of the medicine. Ensure that you maintain adequate calorie intake during treatment. While you are taking this medicine, your doctor may advise regular monitoring of serum calcium levels. This medicine is usually well tolerated with no common side effects. Ensure regular doctor consultation to evaluate medicine effects on your body. Before taking Ketoalfa Tablet, it is important to tell your doctor if you are taking any other medicines for other health conditions.