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'chelating agent'

Items tagged with 'chelating agent'

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General Medicine

Disodium Edetate Injection (also written as EDTA Disodium or Disodium EDTA) is a chelating agent with very limited and specific medical uses due to the risk of serious side effects. 🔹 Approved Medical Uses of Disodium Edetate Injection: 🔻 Treatment of Severe Hypercalcemia Primary use: Treats life-threatening high calcium levels in the blood. It binds to excess calcium ions and helps remove them from the body via the kidneys. 💊 Digitalis (Digoxin) Toxicity (rare/adjunct) In cases of digoxin overdose, disodium EDTA may be used to lower calcium, which worsens digoxin's toxic effects. ⚠️ NOT for Lead Poisoning ⚠️ Very important: Disodium EDTA is not used for lead poisoning. It can dangerously lower blood calcium and cause fatal hypocalcemia. The safe version for lead chelation is Calcium Disodium EDTA (CaNa₂EDTA). 💉 How It’s Given: Intravenously (IV) and must be administered slowly. Requires monitoring of calcium and kidney function. ⚠️ Risks and Side Effects: Severe hypocalcemia (can cause seizures, cardiac arrhythmias, or death). Kidney damage Nausea, vomiting, headache Blood pressure drops Injection site irritation 🚫 Not Approved For: “Detox” or anti-aging therapy Cardiovascular or atherosclerosis treatment (not FDA-approved and unsafe) ✅ Summary: Condition Use of Disodium EDTA Severe Hypercalcemia ✅ Yes Digoxin (digitalis) toxicity ⚠️ Rare, supportive Lead or heavy metal poisoning ❌ NO (use CaNa₂EDTA) Detox / cosmetic use ❌ Not approved/safe

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General Medicine

Disodium EDTA Injection (Ethylenediaminetetraacetic acid, disodium salt) is a chelating agent, similar to calcium disodium EDTA, but with different uses, safety profile, and risks. It’s much less commonly used today due to safety concerns and has narrower indications. 🔹 Main Uses of Disodium EDTA Injection: 🦙 Hypercalcemia (High Blood Calcium Levels) It can be used in emergency treatment of severe hypercalcemia, especially when rapid calcium reduction is required. It works by binding free calcium ions in the blood. 🫀 Digitalis Toxicity (rare use) Sometimes used to manage digoxin toxicity by lowering calcium levels, as excess calcium can worsen digoxin effects. 🧪 Experimental or Unapproved Use: Chelation therapy for atherosclerosis (plaque buildup in arteries): Previously promoted in 'alternative' medicine as a treatment for heart disease. ⚠️ Not FDA-approved for cardiovascular use due to risk of severe side effects including death. ⚠️ Important Warnings & Safety Concerns: Disodium EDTA has been associated with fatal hypocalcemia (low calcium levels) when misused. Because of this, it is generally not used for lead poisoning—Calcium Disodium EDTA (CaNa₂EDTA) is the preferred and safer agent. It requires hospital setting administration with continuous monitoring. 💉 How It’s Given: Administered via IV infusion. Given slowly to prevent rapid electrolyte shifts and heart complications. 🚫 Not Used For: Lead poisoning — too dangerous due to calcium depletion. General detox — not approved or supported by scientific evidence.

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General Medicine

Calcium Edetate Injection (also known as Calcium Disodium EDTA) is a chelating agent used mainly to treat heavy metal poisoning, particularly lead poisoning. 🔹 Primary Uses of Calcium Edetate Injection: 🧪 Lead Poisoning (Plumbism) Main use: binds to lead in the bloodstream and helps eliminate it through the urine. Often used in moderate to severe cases, especially in children and industrial exposure. 🌡️ Other Heavy Metal Toxicity (off-label or less common) May also be used (less commonly) for: Cadmium Zinc (in overload situations) Not used for mercury or arsenic—other chelators like dimercaprol or DMSA are preferred there. 🔄 Diagnostic Use (EDTA lead mobilization test) Sometimes used to test the body's lead burden by observing how much lead is excreted after administration. 💉 How It Works: Chelation therapy: The EDTA binds to heavy metal ions in the blood. The resulting complex is water-soluble and excreted through the kidneys. 💉 Administration: IV (intravenous) or IM (intramuscular) injection. Usually given over several days, depending on lead levels and patient condition. Often used alongside hydration therapy to protect the kidneys. ⚠️ Precautions & Side Effects: Kidney function must be closely monitored — chelation can be hard on the kidneys. Electrolyte imbalances (e.g., calcium, zinc depletion) may occur. Possible side effects: Fever, chills Nausea, vomiting Injection site pain Low blood pressure (rare but serious) ❗ Important Notes: Not the same as disodium EDTA, which is more toxic and not approved for lead poisoning. Must be used under strict medical supervision, especially in children.

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Cats and Dogs

Essential Oto® is a physiological cleanser specifically designed for the regular hygiene of dogs, cats or rabbits’ ears(Excess earwax, Earwax plugs, Bad odors). Based on active ingredients of 100% natural origin, it helps eliminate excessive earwax and debris while deodorizing ear canals. It also has a hydrating and soothing action. Thanks to its alcohol-free formula and its mild ceruminolytic agents, Essential Oto® is perfectly adapted to the maintenance of healthy ears even the most sensitive. Its use is facilitated thanks to a twist-off service cap allowing a single-handed opening. Its transparent bottle enables to check the integrity of the formula throughout the product’s lifespan.

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Cats and Dogs

Vetachlor-M contains the anti-fungal agent Miconazole and the antiseptic Chlorhexidine. While miconazole provides relief from dermatological conditions associated with fungal infections like ringworm, superficial skin infections, chlorhexidine is a broad-spectrum antimicrobial with demonstrated activity against both gram-positive and gram-negative bacteria, yeasts, and viruses. Vetachlor-M is indicated for the fungal infections and dermatitis associated with Staphylococcus intermedius, Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes.

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Cats and Dogs

Oscinap is a combination of N-Acetyl Carnosine (NAC) & Sodium Carboxymethyl celulose (SCMC). Oscinap strengthens eye’s defence against free radicals and prrevents progression of cataracts in cats & dogs. N-Acetyl Carnosine penetrates the eye and gets further metabolized to form L-carnosine, an anti-glycating agent and oxidative stress reducer. When used with SCMC, NAC provides “sustained” action, SCMC is a eye lubricant and muco-adhesive provides temporary relief from burning and discomfort due to the eye’s dryness and acts as a protectant against further irritation.

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Eye Care

Tropind Plus is a combination ophthalmic solution containing Tropicamide 0.8% and Phenylephrine 5%. This formulation is primarily used for both diagnostic and therapeutic purposes in ophthalmology. 🩺 Primary Uses of Tropind Plus 1. Pupillary Dilation (Mydriasis): The combination of Tropicamide and Phenylephrine effectively dilates the pupil, allowing eye care professionals to conduct thorough examinations of the retina, optic nerve, and other internal structures. 2. Cycloplegia: Tropicamide paralyzes the ciliary muscle, preventing accommodation (focusing), which is useful in refractive error assessments. 3. Uveitis Management: In cases of uveitis, Tropind Plus helps alleviate pain and prevents further spasms of the eye muscles. 4. Preoperative Preparation: Before surgeries like cataract extraction or retinal procedures, dilating the pupil is essential for clear visualization of the posterior segment. 5. Retinal Imaging: Facilitates procedures such as fundus photography and optical coherence tomography (OCT) by ensuring adequate pupil dilation. ⚙️ How It Works • Tropicamide is a parasympatholytic agent that inhibits the contraction of the circular muscle and paralyzes the ciliary muscle, leading to pupil dilation and cycloplegia. Phenylephrine is a sympathomimetic drug that causes contraction of the radial muscle of the iris, contributing to pupil dilation. Together, these agents produce rapid and effective dilation of the pupil, facilitating detailed eye examinations and procedures. ⚠️ Side Effects Common side effects may include: • Eye pain or stinging • Blurred vision • Sensitivity to light (photophobia) • Allergic reactions These effects are typically temporary and resolve shortly after the examination. 🧪 Safety and Precautions • Driving and Operating Machinery: Avoid activities that require clear vision, such as driving, immediately after application, as the solution can cause temporary blurred vision. • Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or while breastfeeding, as safety data may be limited. • Drug Interactions: Be cautious when using Tropind Plus with certain medications, especially monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants, as interactions may occur.

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Eye Care

Tropind (Tropicamide 1%) Ophthalmic Solution is commonly used for the following purposes: Pupillary Dilation (Mydriasis): Tropind is often used by eye care professionals to dilate the pupils during eye exams, such as fundoscopy or slit-lamp examinations. It helps them get a clear view of the retina, optic nerve, and other structures inside the eye. Cycloplegia: Tropind is used to temporarily paralyze the ciliary muscle in the eye, which controls the lens's focusing ability. This is useful during certain types of eye exams, such as refraction tests, to evaluate the eye's refractive error without interference from accommodation (focusing). Treatment of Certain Eye Conditions: It may also be used to treat or manage certain eye conditions, such as uveitis (inflammation of the middle layer of the eye), to relieve pain and prevent further spasms of the eye muscles. How it works: Tropind contains tropicamide, which is an anticholinergic agent that works by blocking the action of acetylcholine on the muscles of the iris (pupil) and the ciliary body, causing pupil dilation and paralysis of accommodation. Administration: It is usually instilled directly into the eye as drops. The effects typically last for a few hours, depending on the individual and the purpose of use. Side effects: Potential side effects may include temporary blurry vision, sensitivity to light (due to pupil dilation), or stinging when the drops are first applied. Always follow the instructions provided by your healthcare provider or the product label when using Tropind.

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