Marketer BDR Pharmaceuticals Internationals Pvt SALT COMPOSITION Rucaparib (300mg) Uses of Bdparib Tablet Sickle cell anemia Ovarian cancer Prostate cancer Blood cancer (Acute lymphocytic leukemia) Soft tissue sarcoma Hodgkin’s disease Product introduction Bdparib 300 Tablet is used in the treatment of prostate and ovarian cancers. It works by stopping the repair of damaged cancer cells, which stops their further growth, and kills the damaged cancer cells. Bdparib 300 Tablet can be taken with or without food, but better to have it at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as advised by the doctor. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include increased liver enzymes, decreased appetite, anemia, weakness, gastrointestinal disturbance, acute myeloid leukemia (blood cancer), and nasopharyngitis (inflammation of the throat and nasal passages). Inform your doctor if you notice fever, chills, sore throat, and severe diarrhea. Regular blood tests are required to check your blood cells along with the heart, liver, and blood uric acid levels. It is advised to stay hydrated while taking this medicine to overcome diarrhea. Before taking it, tell your doctor if you have heart disease, liver or kidney problems, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine, so let your healthcare team know about all the medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Effective contraception by both males and females during the treatment is important to avoid pregnancy. Benefits of Bdparib Tablet In Ovarian cancer Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Bdparib 300 Tablet kills the cancer cells and also prevents the repair of damaged cancer cells. It is an effective medicine but has some side effects that may be bothersome. Consult your doctor to know about the ways that can help you avoid these side effects. Side effects of Bdparib Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Bdparib Nasopharyngitis (inflammation of the throat and nasal passages) Rash Increased liver enzymes Decreased appetite Anemia (low number of red blood cells) Weakness Gastrointestinal disturbance Myelodysplastic syndrome Acute myeloid leukemia (blood cancer) How to use Bdparib Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bdparib 300 Tablet may be taken with or without food, but it is better to take it at a fixed time. How Bdparib Tablet works Bdparib 300 Tablet prevents (by blocking certain proteins) cancer cells from repairing their damaged DNA, causing them to die. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Bdparib 300 Tablet. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Bdparib 300 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Marketer BDR Pharmaceuticals Internationals Pvt SALT COMPOSITION Rucaparib (200mg) Uses of Bdparib Tablet Sickle cell anemia Ovarian cancer Prostate cancer Blood cancer (Acute lymphocytic leukemia) Soft tissue sarcoma Hodgkin’s disease Benefits of Bdparib Tablet In Ovarian cancer Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too. It usually spreads to the pelvis and stomach. Bdparib 200 Tablet kills the cancer cells and also prevents the repair of damaged cancer cells. It is an effective medicine but has some side effects that may be bothersome. Consult your doctor to know about the ways that can help you avoid these side effects. Side effects of Bdparib Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Bdparib Nasopharyngitis (inflammation of the throat and nasal passages) Rash Increased liver enzymes Decreased appetite Anemia (low number of red blood cells) Weakness Gastrointestinal disturbance Myelodysplastic syndrome Acute myeloid leukemia (blood cancer) How to use Bdparib Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bdparib 200 Tablet may be taken with or without food, but it is better to take it at a fixed time. How Bdparib Tablet works Bdparib 200 Tablet prevents (by blocking certain proteins) cancer cells from repairing their damaged DNA, causing them to die. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Bdparib 200 Tablet. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Bdparib 200 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding CONSULT YOUR DOCTOR Bdparib 200 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. warnings Driving CONSULT YOUR DOCTOR It is not known whether Bdparib 200 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. warnings Kidney SAFE IF PRESCRIBED Bdparib 200 Tablet is safe to use in patients with kidney disease. No dose adjustment of Bdparib 200 Tablet is recommended. warnings Liver SAFE IF PRESCRIBED Bdparib 200 Tablet is safe to use in patients with liver disease. No dose adjustment of Bdparib 200 Tablet is recommended.

Marketer Getwell Pharma (I) Pvt Ltd SALT COMPOSITION Thiotepa (15mg) Storage Store below 30°C Uses of Tepawel Injection Malignant melanoma Hodgkin’s disease Multiple myeloma Brain tumor Blood cancer Breast cancer Non-small cell lung cancer Ovarian cancer Lung cancer Product introduction Tepawel 15mg Injection is used in the treatment of cancers of the brain, breast, lungs, and ovaries. It is used in combination with other cancer medicine during hematopoietic progenitor cell transplantation (HPCT). It may be also used to treat other conditions, as determined by the doctor. Tepawel 15mg Injection is generally given under the supervision of a healthcare professional. Your doctor will decide the dose and duration of the treatment based on the severity of your condition and what you are being treated for. It may take several weeks or months for you to see or feel the benefits but do not stop getting the injection unless your doctor tells you to. The most common side effects of this medicine include decreased white blood count, anemia, low blood platelets, increased liver enzymes, increased bilirubin in the blood, mucosal inflammation, hemorrhage, diarrhea, blood in urine, and rash. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidneys, liver, and heart function during treatment with this medicine. Before taking it, tell your doctor if you have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Side effects of Tepawel Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Tepawel Decreased white blood cell count (neutrophils) Anemia (low number of red blood cells) Low blood platelets Increased liver enzymes Increased bilirubin in the blood Mucosal inflammation Hemorrhage Rash Diarrhea Blood in urine How to use Tepawel Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Tepawel Injection works Tepawel 15mg Injection is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Tepawel 15mg Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Tepawel 15mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor. warnings Breast feeding UNSAFE Tepawel 15mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. warnings Driving UNSAFE Tepawel 15mg Injection may cause side effects which could affect your ability to drive. It is likely that certain adverse events of Tepawel 15mg Injection are dizziness, headache, and blurred vision which could affect your ability to drive. warnings Kidney SAFE IF PRESCRIBED Tepawel 15mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Tepawel 15mg Injection may not be needed in these patients. Please consult your doctor. warnings Liver CAUTION Tepawel 15mg Injection should be used with caution in patients with liver disease. Dose adjustment of Tepawel 15mg Injection may be needed. Please consult your doctor. Regular monitoring of liver function tests may be advised while you are taking this medicine.

Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Leuprolide (22.5mg) Salt Synonyms Leuprorelin Storage Store in a refrigerator (2 - 8°C). Do not freeze. Uses of Leulide Injection Prostate cancer Endometriosis Uterine fibroids Precocious puberty (premature puberty) Female infertility Product introduction Leulide Depot 22.5mg Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty). Leulide Depot 22.5mg Injection is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Decreased libido, increased sweating, fatigue, muscle weakness, and hot flashes are some very common side effects of this medicine. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. It might cause menstrual periods to stop for a period of 7- 12 weeks, inform your doctor if menstrual bleeding continues even during the treatment. Before taking this medicine, inform your doctor if you have a history of drinking alcohol, smoking, and osteoporosis. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Side effects of Leulide Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Leulide Decreased libido Testicular atrophy Increased sweating Fatigue Muscle weakness Erectile dysfunction Hot flashes How to use Leulide Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Leulide Injection works Leulide Depot 22.5mg Injection reduces the amount of sex hormones (testosterone in men and estrogen in women). It works by decreasing the blood levels of testosterone in males. Leulide Depot 22.5mg Injection also acts by shutting off hormones made by the ovaries (female reproductive organs), so the estrogen (one of the hormones that causes females to have periods) level is lowered.

Marketer Sun Pharmaceutical Industries Ltd SALT COMPOSITION Leuprolide (11.25mg) Salt Synonyms Leuprorelin Storage Store below 25°C Uses of Lupride Injection Prostate cancer Endometriosis Uterine fibroids Precocious puberty (premature puberty) Female infertility Product introduction Lupride Depot 11.25mg Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty). Lupride Depot 11.25mg Injection is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Decreased libido, increased sweating, fatigue, muscle weakness, and hot flashes are some very common side effects of this medicine. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. It might cause menstrual periods to stop for a period of 7- 12 weeks, inform your doctor if menstrual bleeding continues even during the treatment. Before taking this medicine, inform your doctor if you have a history of drinking alcohol, smoking, and osteoporosis. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Side effects of Lupride Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Lupride Decreased libido Testicular atrophy Increased sweating Fatigue Muscle weakness Erectile dysfunction Hot flashes How to use Lupride Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Lupride Injection works Lupride Depot 11.25mg Injection reduces the amount of sex hormones (testosterone in men and estrogen in women). It works by decreasing the blood levels of testosterone in males. Lupride Depot 11.25mg Injection also acts by shutting off hormones made by the ovaries (female reproductive organs), so the estrogen (one of the hormones that causes females to have periods) level is lowered.

Clofi 50mg contains Clomiphene Citrate 50mg, and it's the standard starting dose used for treating female infertility, especially due to problems with ovulation. 🩺 Main Uses of Clofi 50mg: 💡 Inducing Ovulation in Women: Most commonly used for women with Polycystic Ovary Syndrome (PCOS) or anovulation (when the ovaries don't release eggs regularly). It helps stimulate ovulation to improve chances of pregnancy. 👶 Female Infertility (Unexplained or Hormonal): For women who have irregular periods, delayed ovulation, or hormonal imbalances affecting fertility. 👨‍⚕️ Male Infertility (Off-label use): Used to increase testosterone and sperm production in men with low testosterone or low sperm count. Often part of long-term hormone balance therapy. ⚙️ How Clofi 50mg Works: Clomiphene tricks the body into thinking estrogen is low → this causes the brain to release more FSH (Follicle Stimulating Hormone) and LH (Luteinizing Hormone) → triggers the ovaries to mature and release an egg. 💊 Typical Dosage (for Women): Usually taken on Days 2–6 or 3–7 of the menstrual cycle. One tablet (50mg) daily for 5 days. Ovulation usually occurs 5–10 days after the last dose. If ovulation doesn’t occur, your doctor may increase the dose in the next cycle (e.g., 100mg or 150mg). ⚠️ Possible Side Effects: Hot flashes Bloating or abdominal discomfort Mood swings or irritability Breast tenderness Visual disturbances (rare) Ovarian hyperstimulation or cysts (rare) ❗ Important Notes: Should be taken under medical supervision, with monitoring by ultrasound or hormone tests. Increases chances of multiple pregnancies (twins or more). Not suitable for women with certain conditions like liver disease, abnormal vaginal bleeding, or ovarian cysts (non-PCOS-related).

Tropicamide Ophthalmic Solution USP 0.5% is a sterile, anticholinergic eye drop used primarily for diagnostic purposes in ophthalmology. ________________________________________ 🔍 Primary Uses 1. Pupillary Dilation (Mydriasis): Tropicamide 0.5% is employed to dilate the pupil, facilitating detailed examination of the retina, optic nerve, and other internal eye structures during procedures like fundoscopy and slit-lamp assessments. 2. Cycloplegia: It temporarily paralyzes the ciliary muscle, preventing accommodation (focusing), which is useful in refractive error assessments. 3. Management of Uveitis: Tropicamide 0.5% is utilized in treating conditions like acute and subacute iridocyclitis, chronic iridocyclitis, and to prevent adhesions and disruptions of the iris and ciliary body. ________________________________________ ⚠️ Side Effects While generally well-tolerated, potential side effects may include: • Temporary stinging or burning sensation upon instillation • Blurred vision • Sensitivity to light (photophobia) • Dry mouth • Headache • Nausea or vomiting • Pale skin • Central nervous system disturbances, including agitation or confusion, especially in pediatric patients ________________________________________ 🧪 Usage Instructions • Administration: Instill one or two drops into the affected eye(s) as directed by your healthcare provider. • Contact Lenses: Remove contact lenses before application. • Hygiene: Avoid touching the dropper tip to any surface to prevent contamination. • Post-application: Apply gentle pressure to the inner corner of the eye for 1–3 minutes to minimize systemic absorption. ________________________________________ ⚠️ Precautions • Driving and Operating Machinery: Avoid engaging in activities requiring clear vision, such as driving, until the effects of the medication have worn off. • Pediatric Use: Use with caution in children, as anticholinergic drugs may cause CNS disturbances. • Pregnancy and Breastfeeding: Consult your healthcare provider before use during pregnancy or while breastfeeding.

Biotrav (Travoprost) Ophthalmic Solution Biotrav is a prescription eye drop containing travoprost, a prostaglandin analog used to lower intraocular pressure (IOP) in individuals with open-angle glaucoma or ocular hypertension. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common type of glaucoma characterized by gradual loss of vision due to increased IOP. • Ocular Hypertension: Elevated IOP without optic nerve damage, which can lead to glaucoma if untreated. ________________________________________ 💊 Dosage and Administration • Recommended Dosage: Instill one drop into the affected eye(s) once daily in the evening. • Application Tips: o Wash hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to travoprost or any component of the formulation. o Active or suspected ocular infections. o History of hypersensitivity to prostaglandin analogs. • Cautions: o Use with caution in patients with a history of uveitis, macular edema, or retinal vein occlusion. o May cause changes in eye color, eyelash growth, and skin pigmentation around the eyes. o Consult a healthcare provider before use if pregnant, planning to become pregnant, or breastfeeding. ________________________________________ 🧪 Mechanism of Action Travoprost works by increasing the outflow of aqueous humor through the trabecular meshwork and uveoscleral pathways, thereby reducing IOP. This helps prevent damage to the optic nerve and loss of vision associated with glaucoma and ocular hypertension.

Biotrav-T (Travoprost and Timolol Maleate) Ophthalmic Solution is a prescription eye drop used to manage elevated intraocular pressure (IOP) in individuals with open-angle glaucoma or ocular hypertension. It combines two medications—travoprost (a prostaglandin analog) and timolol maleate (a non-selective beta-blocker)—to reduce IOP through complementary mechanisms. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common form of glaucoma characterized by gradual loss of vision due to increased IOP. • Ocular Hypertension: Elevated IOP without optic nerve damage, which can lead to glaucoma if untreated. ________________________________________ 💊 Dosage and Administration • Recommended Dosage: Instill one drop into the affected eye(s) once daily, preferably in the evening. • Application Tips: o Wash hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Active or suspected ocular infections. o History of hypersensitivity to beta-blockers. • Cautions: o Use with caution in patients with cardiovascular or pulmonary diseases, as timolol may exacerbate conditions like asthma, bradycardia, or heart block. o Monitor for potential systemic absorption effects, including hypotension or bradycardia. o Consult a healthcare provider before use if pregnant, planning to become pregnant, or breastfeeding. ________________________________________