STELARA 130 mg Injection
@ERNESTPHARMACEUTICALPVTLTD
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Description
STELARA (Ustekinumab) 130 mg is a biologic, human monoclonal antibody that targets immune signaling proteins involved in inflammation. Specifically, it binds to the p40 subunit shared by interleukin-12 (IL-12) and interleukin-23 (IL-23).
By blocking these cytokines, STELARA modulates the immune response and helps reduce chronic inflammation.
Drugs.com
STELARA is indicated for treatment of:
Moderate to severe plaque psoriasis
European Medicines Agency (EMA)
Psoriatic arthritis
Moderately to severely active Crohn’s disease
Moderately to severely active ulcerative colitis
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Mechanism of Action
Ustekinumab binds specifically to the p40 subunit of IL-12 and IL-23.
By blocking IL-12 and IL-23, it reduces the activation of key inflammatory pathways (including certain T-cells) that contribute to chronic inflammatory diseases.
This immunomodulation helps decrease inflammation in skin, joints, and the gastrointestinal tract.
Benefits of STELARA 130 mg Injection
Reduces Skin Lesions in Psoriasis: Helps clear plaques, scaling, and redness, improving quality of life.
Improves Joint Symptoms: Reduces pain, swelling, and inflammation in psoriatic arthritis.
Manages Inflammatory Bowel Disease: In Crohn’s disease and ulcerative colitis, STELARA helps control flares, reduce abdominal pain, and improve bowel function.
Long Dosing Interval: After initial dosing, maintenance injections are spaced out (depending on disease), which improves convenience.
European Medicines Agency (EMA)
Targeted Therapy: Because it specifically blocks IL-12 and IL-23, it may avoid some broader immunosuppressive side effects of older therapies.
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Ernest Pharmaceutical Pvt. Ltd.
📧 Email: exports@ernestpharmaceuticals.com
Side Effects of STELARA 130 mg Injection
Common Side Effects
Upper respiratory tract infections (e.g., cold, sore throat)
Headache
Fatigue / tiredness
Injection site reactions (itching, redness, pain)
Gastrointestinal symptoms (in patients with IBD): abdominal pain, diarrhea, nausea
Serious / Less Common Side Effects
Increased risk of infections, including serious infections (due to immune suppression)
Allergic reactions: swelling, hives, shortness of breath
Rarely: posterior reversible encephalopathy syndrome (PRES) — a neurological condition that can cause seizures, confusion, headache, or vision changes.
Possible long-term risks: malignancy (due to immune modulation)
Safety and Precautions
Screening for latent infections (e.g., tuberculosis) is advised before starting STELARA.
Patients should be monitored for signs of infection throughout treatment.
Use with caution in patients with a history of malignancy.
Live vaccines should generally be avoided during treatment.
Pregnant or breastfeeding patients should discuss risks and benefits with their physician.
Regular follow-up and laboratory monitoring may be required as advised by the treating physician.
Conclusion
STELARA 130 mg Injection (Ustekinumab) is a modern, targeted biologic therapy that effectively treats autoimmune inflammatory conditions like psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. By inhibiting key inflammatory cytokines (IL-12 and IL-23), it offers strong disease control, improved quality of life, and a favorable dosing schedule. While generally well tolerated, patients should be monitored for infections and rare neurological effects.
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