Abhope 50mg Injection
Buy Abhope 50mg Liposomal Amphotericin B Injection in Kingston, Jamaica. Trusted antifungal supplier for hospitals and distributors.
Generic Name: Liposomal Amphotericin B (50mg)
Manufacturer / Marketer: Abbott
Regulatory Status: NPPA Regulated
Prescription: Required
Storage: Store in a refrigerator (2°C – 8°C). Do not freeze.
Product Description
Abhope 50mg Injection is a liposomal formulation of Amphotericin B, an antifungal and antiprotozoal medication. It is primarily used for the treatment of severe systemic fungal infections and visceral leishmaniasis (kala-azar).
This liposomal delivery system enhances drug targeting to infected tissues while minimizing exposure to healthy cells, significantly reducing toxicity—especially nephrotoxicity—compared to conventional Amphotericin B formulations.
Abhope 50mg Injection works by binding to ergosterol, a vital component of fungal and protozoal cell membranes. This interaction disrupts membrane integrity, leading to leakage of cellular contents and ultimately causing cell death.
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Therapeutic Indications
Abhope 50mg Injection is indicated for:
Treatment of severe systemic fungal infections, including aspergillosis, cryptococcosis, mucormycosis, and candidiasis.
Treatment of visceral leishmaniasis (kala-azar) caused by Leishmania donovani.
Dosage and Administration
Administered intravenously by a qualified healthcare professional only.
Dosage and treatment duration depend on the type and severity of infection, patient weight, and clinical response.
Must not be administered by rapid infusion or intramuscular route.
Renal and hepatic function should be monitored regularly during therapy.
Mechanism of Action
Liposomal Amphotericin B binds to ergosterol in the cell membranes of susceptible fungi and protozoa. The binding forms transmembrane pores, increasing permeability and leading to leakage of essential cellular components.
The liposomal encapsulation allows targeted drug delivery to infected sites, reduces systemic toxicity, and improves therapeutic outcomes, particularly in immunocompromised patients.
Benefits of Abhope 50mg Injection
Broad-spectrum activity against pathogenic fungi and Leishmania species.
Lower renal toxicity and improved tolerability versus conventional Amphotericin B.
Effective first-line treatment for severe, life-threatening fungal infections.
Enhanced safety profile suitable for use in immunocompromised and critically ill patients.
Common Side Effects
Most side effects are mild and resolve as the body adjusts to the medication. Common adverse reactions include:
Fever and chills
Nausea and vomiting
Decreased potassium levels (hypokalemia)
Mild infusion-related reactions
Patients should be closely monitored for electrolyte imbalance and renal function throughout treatment.
Precautions & Warnings
Pregnancy: Considered generally safe when prescribed; animal studies indicate minimal fetal risk.
Breastfeeding: Not recommended; potential transfer to breast milk may harm the infant.
Kidney Impairment: Generally safe, though monitoring is advised.
Liver Impairment: Use with caution; limited data available.
Alcohol: Safety not established; consult physician before consumption.
Driving/Operating Machinery: Use caution if experiencing dizziness, fatigue, or infusion-related effects.
Storage Instructions
Store under refrigeration (2°C – 8°C).
Do not freeze or shake.
Protect from light and keep out of reach of children.
Key Highlights
Category: Antifungal / Antiprotozoal
Form: Injection (Liposomal formulation)
Strength: 50 mg per vial
Route of Administration: Intravenous infusion
Manufacturer: Abbott
Regulatory Status: NPPA Regulated
