Imipenem & Cilastatin 500mg Injection Exporter from India to USA, UK, Australia, Singapore, Thailand, and Jamaica | Premium Carbapenem Antibiotic Supplier | Ernest Impex Global Medicine Logistics

Extensive Product Profile: Understanding Imipenem and Cilastatin for Injection 500 mg

Imipenem and Cilastatin for Injection 500 mg is a potent, broad-spectrum carbapenem antibiotic combination. It consists of Imipenem, a thienamycin antibiotic, and Cilastatin sodium, a specific enzyme inhibitor that prevents the renal metabolism of imipenem, thereby maintaining higher therapeutic concentrations of the antibiotic in the body.

1. Clinical Indications & Usage

This combination therapy is indicated for the treatment of serious bacterial infections caused by susceptible organisms. Its broad spectrum makes it a vital option for hospital-based care, including:

Lower Respiratory Tract Infections: Management of severe pneumonia and bronchitis.

Urinary Tract Infections (UTIs): Treatment of complicated and uncomplicated infections, including pyelonephritis.

Intra-Abdominal Infections: Used in the treatment of peritonitis and other complex infections within the abdomen.

Gynecological Infections: Management of postpartum infections and endometritis.

Skin and Soft Tissue Infections: Treatment of severe skin infections, including those involving diabetic foot ulcers.

Bone and Joint Infections: Used for the treatment of osteomyelitis and septic arthritis.

Septicemia and Endocarditis: Management of severe systemic bacterial infections and serious heart valve infections.

2. Mechanism of Action

The combination utilizes a dual-component strategy to maximize antibacterial efficacy:

Imipenem: Acts as a potent bactericidal agent by binding to Penicillin-Binding Proteins (PBPs) in the bacterial cell wall, which inhibits cell wall peptidoglycan synthesis, leading to bacterial cell death.

Cilastatin: While it possesses no inherent antibacterial activity, it acts as a competitive, reversible inhibitor of the enzyme dehydropeptidase I, found in the renal brush border. By inhibiting this enzyme, cilastatin prevents the renal degradation of imipenem, ensuring that sufficient levels of the antibiotic reach the site of infection and reducing potential renal toxicity.

3. Administration and Dosing

Route: Administered exclusively via intravenous (IV) infusion.

Preparation: The sterile powder must be reconstituted with compatible IV fluids (such as 0.9% Sodium Chloride) and further diluted for infusion.

Dosing: Dosage is strictly personalized by a healthcare provider based on the patient’s age, body weight, severity of the infection, and renal function. It is typically administered every 6 to 8 hours.

⚠️ Safety, Side Effects, and Monitoring

Hypersensitivity: Contraindicated in patients with a history of severe hypersensitivity (anaphylaxis) to any carbapenem or beta-lactam antibiotic.

CNS Precautions: As with other carbapenems, there is a risk of central nervous system (CNS) adverse effects, including seizures. Patients with a history of CNS disorders or renal impairment should be monitored closely.

Common Side Effects: Observed side effects include nausea, vomiting, diarrhea, local injection site reactions (e.g., phlebitis), and skin rashes.

Monitoring: Patients should be monitored for signs of C. difficile-associated diarrhea and for clinical response during the treatment course.

📦 Storage and Handling

Storage: Keep the un-reconstituted powder in its original packaging at controlled room temperature (20°C to 25°C), away from moisture and direct light.

Stability: Reconstituted solutions should be used immediately according to institutional sterile protocols to maintain efficacy.

PRESCRIPTION MEDICINE IS : YES

Clinical Disclaimer: This profile is compiled for medical professional information and clinical research. Imipenem and Cilastatin for Injection 500 mg is a prescription-only medication and must be administered strictly under the supervision of a licensed physician. Its use during pregnancy or breastfeeding should be evaluated by a doctor based on the potential benefit versus risk.

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