Kidney disease is a silent killer in dogs & cats. In older population, as many as 10% of dogs and 35% cats have chronic kidney disease. Kynetra is a kidney health support formula that contains proven Chinese herbs and vitamins that help to maintain and support kidney function. has potential to slow down the progression of kidney disease. Kynetra contains scientifically proven Chinese herbs, Rehmannia glutinosa, Astragalus, Cordycepsus sinensis, is indicated for AKI – Acute Kidney Injury & Chronic CKD Conditions Slows down CKD Progression Supplementation is beneficial in CKD including nephropathy secondary to diabetes, and hypertension Helps in recovery from vitamin deficiency caused by CKD Has shown potential to decrease serum creatinine, increase creatine clearance Reduce proteinuria and alleviate CKD-associated complications Helps in preventing damage to nephrons from oxidative stress caused by CKD. Improves Kidneys function by reducing excretion of proteins. Acts as reno protective.

Piratacan 200 Injection contains Piracetam 200 mg, a nootropic medication that enhances cognitive function and neurological health. It is used in both adults and children above 8 years of age for various neurological conditions. ________________________________________ 🧠 Common Uses 1. Cognitive Disorders in the Elderly Piratacan 200 Injection is used to manage memory loss, lack of concentration, mood changes, and behavioral alterations associated with aging. 2. Myoclonus (Movement Disorders) It is effective in treating myoclonus, a condition characterized by involuntary muscle jerks. 3. Vertigo (Dizziness) The injection helps alleviate dizziness and balance issues, improving overall stability. 4. Dyslexia in Children In children above 8 years, Piratacan 200 Injection is used to treat learning difficulties, particularly those related to reading and understanding text. ________________________________________ ⚙️ Mechanism of Action Piracetam, the active ingredient in Piratacan 200 Injection, acts on the brain and nervous system by: Enhancing the activity of acetylcholine, a neurotransmitter vital for memory and learning. • Improving oxygen and glucose utilization in the brain. • Protecting against shortness of oxygen, thereby supporting overall brain function. ________________________________________ 💉 Administration Piratacan 200 Injection is administered intravenously or intramuscularly by a healthcare professional. The dosage and frequency depend on the specific condition being treated and the patient's response to therapy. ________________________________________ ⚠️ Side Effects Common side effects may include: • Nausea or vomiting • Headache • Abdominal pain • Pain at the injection site • These side effects are generally mild and temporary. However, if they persist or worsen, consult your healthcare provider. ________________________________________ ⚠️ Precautions Before receiving Piratacan 200 Injection, inform your doctor if you have: • Kidney or liver disease • Bleeding disorders • Allergies to piracetam or any other ingredients in the injection. • Additionally, disclose any other medications you are taking, as interactions may occur. Pregnant or breastfeeding individuals should consult their healthcare provider before use.

Milrican 10 is a brand of Milrinone Lactate Injection, manufactured by American Remedies. Milrinone is a phosphodiesterase-3 (PDE3) inhibitor that serves as both an inotropic agent and a vasodilator. ________________________________________ ✅ Primary Uses of Milrican 10 Milrican 10 is indicated for the short-term intravenous treatment of: • Severe congestive heart failure: Particularly in patients unresponsive to conventional therapies. • Acute decompensated heart failure: Including low output states following cardiac surgery. It is commonly used in intensive care units or during cardiac procedures to support heart function. ________________________________________ ⚙️ Mechanism of Action Milrinone works by inhibiting PDE3, leading to increased cyclic AMP (cAMP) levels in cardiac and vascular smooth muscle cells. This results in: • Increased myocardial contractility: Enhancing the heart's ability to pump blood. • Vasodilation: Relaxing blood vessels, which reduces the heart's workload and improves blood flow. ________________________________________ ⚠️ Important Considerations • Administration: Milrican 10 should only be administered intravenously under the supervision of a healthcare professional. • Monitoring: Patients receiving Milrican 10 require close monitoring of blood pressure, heart rate, and kidney function. • Contraindications: Not recommended for patients with severe dehydration, electrolyte imbalances, or known hypersensitivity to milrinone. • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.

Combinib 250mg Tablet is used in the treatment of breast cancer. It works by stopping or slowing down the growth of cancer cells. It is either used alone or in combination with some other medicine to cure advanced-stage breast cancer. Combinib 250mg Tablet should be taken on an empty stomach or an hour before or 2 hours after a meal. The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea, or vomiting. Your doctor may check your liver function before, during, and after treatment with this medicine. Before taking Combinib 250mg Tablet, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details. Uses of Combinib Tablet Pancreatic cancer Small cell lung cancer Liver cancer Kidney cancer Thyroid cancer Blood cancer (Chronic myeloid leukaemia) Gastrointestinal stromal tumour Cancer of colon and rectum Non-small cell lung cancer Soft tissue sarcoma Chronic idiopathic myelofibrosis Breast cancer Side effects of Combinib Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Combinib Abdominal pain Back pain Breathing problems Constipation Cough Diarrhea Fatigue Headache Hot flashes Increased bilirubin in the blood Insomnia (difficulty in sleeping) Joint pain Liver damage Loss of appetite Mucosal inflammation Nausea Pain in extremities Rash Stomatitis (Inflammation of the mouth) Vomiting Weakness Weight gain How to use Combinib Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combinib 250mg Tablet is to be taken empty stomach. How Combinib Tablet works Combinib 250mg Tablet is an anti-cancer medication. It works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which are responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Combinib 250mg Tablet. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Combinib 250mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor. warnings Breast feeding UNSAFE Combinib 250mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. warnings Driving UNSAFE Combinib 250mg Tablet may cause side effects which could affect your ability to drive. warnings Kidney CAUTION Combinib 250mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor. Limited information is available on the use of Combinib 250mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. warnings Liver CAUTION Combinib 250mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor. Limited information is available on the use of this medicine in patients with the severe liver disease.

Marketer Cipla Ltd SALT COMPOSITION Abiraterone Acetate (250mg) Storage Store below 30°C Uses of Xbira Tablet Sickle cell anemia Prostate cancer Blood cancer (Acute lymphocytic leukemia) Soft tissue sarcoma Hodgkin’s disease Product introduction Xbira 250mg Tablet is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy. Xbira 250mg Tablet should not be taken on an empty stomach. Taking it with food may cause side effects. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include vomiting, decreased potassium level in blood, edema (swelling), decreased white blood cell count, fatigue and increased liver enzymes. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Other than this, yellowing of skin, loss of appetite, shortness of breath, dark urine and nausea can happen, which indicate some liver problem. Your doctor might check you for liver function, blood pressure, and the level of potassium in your blood. Before taking it, tell your doctor if have high blood pressure, heart problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment. There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details. Side effects of Xbira Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Xbira Edema (swelling) Vomiting Decreased potassium level in blood Fatigue Anemia (low number of red blood cells) Urinary tract infection Diarrhea High blood pressure Cough Joint swelling How to use Xbira Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xbira 250mg Tablet is to be taken empty stomach. How Xbira Tablet works Xbira 250mg Tablet is an anticancer medication. It works by preventing androgen (male hormone) production in man. This is done by inhibiting an enzyme (CYP17) that is responsible for the production of androgen. This is how it slows down the growth of prostate cancer.

Marketer Cipla Ltd SALT COMPOSITION Abiraterone Acetate (500mg) Storage Store below 30°C Uses of Xbira Tablet Sickle cell anemia Prostate cancer Blood cancer (Acute lymphocytic leukemia) Soft tissue sarcoma Hodgkin’s disease Product introduction Xbira 500 Tablet is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy. Xbira 500 Tablet should not be taken on an empty stomach. Taking it with food may cause side effects. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include vomiting, decreased potassium level in blood, edema (swelling), decreased white blood cell count, fatigue and increased liver enzymes. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Other than this, yellowing of skin, loss of appetite, shortness of breath, dark urine and nausea can happen, which indicate some liver problem. Your doctor might check you for liver function, blood pressure, and the level of potassium in your blood. Before taking it, tell your doctor if have high blood pressure, heart problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment. There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details. Side effects of Xbira Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Xbira Edema (swelling) Vomiting Decreased potassium level in blood Fatigue Anemia (low number of red blood cells) Urinary tract infection Diarrhea High blood pressure Cough Joint swelling How to use Xbira Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xbira 500 Tablet is to be taken empty stomach. How Xbira Tablet works Xbira 500 Tablet is an anticancer medication. It works by preventing androgen (male hormone) production in man. This is done by inhibiting an enzyme (CYP17) that is responsible for the production of androgen. This is how it slows down the growth of prostate cancer.

Dobutacan 12 Injection is a brand of Dobutamine Hydrochloride 12.5 mg/mL, a synthetic catecholamine used in critical care settings to support heart function. It is administered intravenously under medical supervision. ________________________________________ 🩺 Medical Uses Dobutacan 12 Injection is indicated for: • Cardiac Decompensation: Acute heart failure due to conditions like myocardial infarction, cardiomyopathies, or post-cardiac surgery. • Cardiogenic Shock: A state of low cardiac output leading to inadequate tissue perfusion. • Septic Shock: A severe infection causing low blood pressure and organ dysfunction. • Stress Echocardiography: As a pharmacological agent to assess coronary artery disease when exercise is not feasible. It works by stimulating beta-1 adrenergic receptors, increasing heart contractility and stroke volume, thereby improving cardiac output. ________________________________________ ⚙️ Dosage and Administration Dobutacan 12 Injection is administered intravenously in a hospital setting. The typical dosage ranges from 2.5 to 10 mcg/kg/min, adjusted based on the patient's response. In some cases, doses up to 20 mcg/kg/min may be required. ________________________________________ ⚠️ Precautions and Contraindications Before using Dobutacan 12 Injection, inform your healthcare provider if you have: • Allergies to dobutamine or other components of the injection. • A history of arrhythmias or heart disease. • Kidney or liver problems. • A history of stroke or blood clots. This medication is typically administered by healthcare professionals in a clinical setting and is not intended for self-administration. It is usually given as an intramuscular (IM) or intravenous (IV) injection. ________________________________________ 💊 Side Effects Common side effects may include: • Headache • Nausea or vomiting • Dizziness or lightheadedness • Injection site reactions (pain, redness, or swelling) Serious side effects are rare but can occur. Seek immediate medical attention if you experience symptoms like chest pain, shortness of breath, or signs of gastrointestinal bleeding.

Calciglu Injection is a medicinal formulation containing Calcium Gluconate, produced by American Remedies. It is primarily used to address conditions arising from calcium deficiencies. ________________________________________ 🩺 Uses of Calciglu Injection Calciglu Injection is administered intravenously to treat: • Hypocalcemia: Low blood calcium levels due to various causes. • Hypocalcemic Tetany: Muscle spasms or cramps resulting from low calcium levels. • Hypoparathyroidism: A condition where the parathyroid glands produce insufficient parathyroid hormone, leading to low calcium levels. • Calcium Deficiency During Pregnancy or Rapid Growth: Increased calcium requirements during these periods. • Hyperkalemia: High potassium levels in the blood, where calcium gluconate can help stabilize the heart's electrical activity. Magnesium Toxicity: Overdose of magnesium sulfate, often used in obstetric care, where calcium gluconate acts as an antidote. • Cardiac Arrest: To support heart function during resuscitation efforts. • Lead or Fluoride Poisoning: Calcium gluconate can bind to certain toxins, aiding in their removal from the body. ________________________________________ ⚠️ Precautions • Administration: Should be administered by a healthcare professional via intravenous injection. • Monitoring: Regular monitoring of calcium levels is essential to avoid complications. • Kidney Function: Use with caution in patients with renal impairment, as calcium accumulation can occur. • Drug Interactions: Inform your healthcare provider of all medications you're taking to avoid potential interactions.

Canrise D3 6L Injection is a high-dose Vitamin D3 (Cholecalciferol) supplement manufactured by American Remedies. It is primarily used to address significant Vitamin D deficiencies and related bone health issues. ________________________________________ 🩺 Uses of Canrise D3 6L Injection • Vitamin D Deficiency: To replenish low levels of Vitamin D, which is essential for calcium absorption and bone health. • Osteoporosis: To improve calcium absorption and bone mineralization, reducing the risk of fractures. • Osteomalacia: To treat softening of the bones due to Vitamin D deficiency. • Adjuvant in Calcium Supplementation: To enhance the effectiveness of calcium supplements in individuals with low Vitamin D levels. ________________________________________ 💊 Mechanism of Action Vitamin D3 aids in the absorption of calcium and phosphate from the intestine, regulates calcium levels in the blood, and supports bone mineralization. It also plays a role in immune function and inflammation reduction. ________________________________________ ⚠️ Precautions • Contraindications: Individuals with hypercalcemia (high calcium levels), hypercalciuria (high calcium in urine), or severe kidney impairment should avoid this injection. • Monitoring: Regular monitoring of calcium and phosphate levels is recommended during treatment. • Administration: Should be administered under medical supervision, typically in a clinical setting.