Introduction to Xolnic 4mg Injection Xolnic 4mg contains the active substance Zoledronic Acid. It belongs to the group of substances called bisphosphonates. It is used to reduce the amount of calcium in the blood in adult patients where it is too high due to the presence of a tumor. Tumors can accelerate normal bone change in such a way that the release of calcium from bone is increased. This condition is known as tumor-induced hypercalcemia (TIH). It is also used to prevent bone complications in adult patients with multiple myeloma and bone metastases from solid tumors (spread of cancer from the primary site to the bone), in addition to standard cancer therapy. Xolnic 4mg is also indicated to prevent or treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause. It is also used to treat osteoporosis in men. It is used to treat Paget’s disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Other uses include treating or preventing osteoporosis in men and women taking glucocorticoids (a corticosteroid medication that may cause osteoporosis). Do not take this injection if you are allergic to zoledronic acid, another bisphosphonate, or any other ingredients of this medicine and if you are pregnant or breastfeeding. Before initiating the treatment, inform your physician if you have kidney or liver problems, bone diseases, pain, swelling, or jaw numbness. This medicine is not recommended for use in adolescents and children below the age of 18 years. Xolnic 4mg is not cancer chemotherapy and will not slow or stop the spread of cancer. However, it can be used to treat bone diseases in patients with cancer. Uses of Xolnic 4mg Injection Treat hypercalcemia of malignancy Multiple myeloma Bone metastases from solid tumors Osteoporosis in postmenopausal women Osteoporosis in men Paget’s disease of bone Therapeutic Effects of Xolnic 4mg Injection Xolnic 4mg primarily inhibits bone resorption. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood. Interaction of Xolnic 4mg Injection with other drugs Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications like aminoglycosides, loop diuretics, and nephrotoxic drugs may interact with Xolnic 4mg and reduce its effectiveness by causing undesirable side effects. More Information about Xolnic 4mg Injection Store Xolnic 4mg at room temperature (20°C to 25°C) keep the injection away from the reach of children and pets. If you have missed any dosing appointments, inform your doctor and schedule immediately. How to consume Xolnic 4mg Injection It should only be administered by a trained doctor or nurse. It will be given as a drip (infusion) into your vein. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors. Do not self-administer the medication. Safety Advices for Xolnic 4mg Injection Image Not Available Pregnancy Xolnic 4mg is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Image Not Available Breast Feeding Breastfeeding is not recommended in patients taking Xolnic 4mg because the medicine passes into the breast milk in small amounts and may harm your baby. Image Not Available Lungs It is unknown whether Xolnic 4mg can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment. Image Not Available Liver It is unknown whether Xolnic 4mg can be used in patients with liver disorders. Inform your physician if you have liver problems before initiating the therapy. Image Not Available Alcohol Caution is advised when consuming alcohol with Xolnic 4mg. Please consult your doctor. Image Not Available Driving It is unsafe to drive or operate heavy machinery after using Xolnic 4mg as this medicine causes drowsiness and sleepiness. Side Effects of Xolnic 4mg Injection Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Common Nausea, vomiting Fatigue Anemia Bone pain Constipation, diarrhea dyspnea, and fever Swelling in the legs and feet Decreased weight Abdominal pain Muscle pain Tiredness Serious Changes in heart rhythm Severe hypersensitivity skin reactions Decreased calcium levels Severe bone pain Severe kidney problems Unusual fractures of the bone

Canrise D3 6L Injection is a high-dose Vitamin D3 (Cholecalciferol) supplement manufactured by American Remedies. It is primarily used to address significant Vitamin D deficiencies and related bone health issues. ________________________________________ 🩺 Uses of Canrise D3 6L Injection • Vitamin D Deficiency: To replenish low levels of Vitamin D, which is essential for calcium absorption and bone health. • Osteoporosis: To improve calcium absorption and bone mineralization, reducing the risk of fractures. • Osteomalacia: To treat softening of the bones due to Vitamin D deficiency. • Adjuvant in Calcium Supplementation: To enhance the effectiveness of calcium supplements in individuals with low Vitamin D levels. ________________________________________ 💊 Mechanism of Action Vitamin D3 aids in the absorption of calcium and phosphate from the intestine, regulates calcium levels in the blood, and supports bone mineralization. It also plays a role in immune function and inflammation reduction. ________________________________________ ⚠️ Precautions • Contraindications: Individuals with hypercalcemia (high calcium levels), hypercalciuria (high calcium in urine), or severe kidney impairment should avoid this injection. • Monitoring: Regular monitoring of calcium and phosphate levels is recommended during treatment. • Administration: Should be administered under medical supervision, typically in a clinical setting.

Disodium Edetate Injection (also written as EDTA Disodium or Disodium EDTA) is a chelating agent with very limited and specific medical uses due to the risk of serious side effects. 🔹 Approved Medical Uses of Disodium Edetate Injection: 🔻 Treatment of Severe Hypercalcemia Primary use: Treats life-threatening high calcium levels in the blood. It binds to excess calcium ions and helps remove them from the body via the kidneys. 💊 Digitalis (Digoxin) Toxicity (rare/adjunct) In cases of digoxin overdose, disodium EDTA may be used to lower calcium, which worsens digoxin's toxic effects. ⚠️ NOT for Lead Poisoning ⚠️ Very important: Disodium EDTA is not used for lead poisoning. It can dangerously lower blood calcium and cause fatal hypocalcemia. The safe version for lead chelation is Calcium Disodium EDTA (CaNa₂EDTA). 💉 How It’s Given: Intravenously (IV) and must be administered slowly. Requires monitoring of calcium and kidney function. ⚠️ Risks and Side Effects: Severe hypocalcemia (can cause seizures, cardiac arrhythmias, or death). Kidney damage Nausea, vomiting, headache Blood pressure drops Injection site irritation 🚫 Not Approved For: “Detox” or anti-aging therapy Cardiovascular or atherosclerosis treatment (not FDA-approved and unsafe) ✅ Summary: Condition Use of Disodium EDTA Severe Hypercalcemia ✅ Yes Digoxin (digitalis) toxicity ⚠️ Rare, supportive Lead or heavy metal poisoning ❌ NO (use CaNa₂EDTA) Detox / cosmetic use ❌ Not approved/safe

Disodium EDTA Injection (Ethylenediaminetetraacetic acid, disodium salt) is a chelating agent, similar to calcium disodium EDTA, but with different uses, safety profile, and risks. It’s much less commonly used today due to safety concerns and has narrower indications. 🔹 Main Uses of Disodium EDTA Injection: 🦙 Hypercalcemia (High Blood Calcium Levels) It can be used in emergency treatment of severe hypercalcemia, especially when rapid calcium reduction is required. It works by binding free calcium ions in the blood. 🫀 Digitalis Toxicity (rare use) Sometimes used to manage digoxin toxicity by lowering calcium levels, as excess calcium can worsen digoxin effects. 🧪 Experimental or Unapproved Use: Chelation therapy for atherosclerosis (plaque buildup in arteries): Previously promoted in 'alternative' medicine as a treatment for heart disease. ⚠️ Not FDA-approved for cardiovascular use due to risk of severe side effects including death. ⚠️ Important Warnings & Safety Concerns: Disodium EDTA has been associated with fatal hypocalcemia (low calcium levels) when misused. Because of this, it is generally not used for lead poisoning—Calcium Disodium EDTA (CaNa₂EDTA) is the preferred and safer agent. It requires hospital setting administration with continuous monitoring. 💉 How It’s Given: Administered via IV infusion. Given slowly to prevent rapid electrolyte shifts and heart complications. 🚫 Not Used For: Lead poisoning — too dangerous due to calcium depletion. General detox — not approved or supported by scientific evidence.

Doxypet Mono contains Doxycycline, the drug of choice in Vector borne diseases like Babesiosis, Ehrlichiosis and Leptospirosis. Doxycycline acts as anti-protozoal antibiotic. Doxypet Mono is indicated for quick relief from severe protozoal infections when dog is not taking food by mouth or is vomiting.

Hyperphosphatemia or high phosphorus levels in the blood is one of the most common conditions during the progression of kidney disease in dogs and cats. Phosphate binders are medications used to reduce the absorption of dietary phosphate. Sevelamer carbonate is a calcium-free, aluminium-free, non-metal phosphate binder for dogs & cats. Phoslure treats hyperphosphatemia in patients with chronic kidney disease without the risk of hypercalcemia or aluminium toxicity. It significantly slows the progression of vascular calcification as compared to calcium-phosphate binders and reduces cardiovascular morbidity and mortality.

Tobi (Tobramycin Ophthalmic Solution) is a prescription antibiotic eye drop used to treat bacterial infections of the eye. It contains 0.3% tobramycin, a broad-spectrum aminoglycoside antibiotic effective against various gram-positive and gram-negative bacteria. ________________________________________ ✅ Primary Uses • Bacterial Conjunctivitis: Infection of the conjunctiva (the membrane covering the white part of the eye and the inner surface of the eyelids). • Blepharitis: Inflammation of the eyelid margins, often associated with bacterial infection. • Keratitis: Infection of the cornea. • Post-surgical Infections: Prophylactic treatment or management of infections following eye surgeries. Tobramycin ophthalmic solution is typically used alone or in combination with other medications, depending on the severity and type of infection . ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye every 4 hours during the day. • Severe Infections: In some cases, the dosage may be increased to 2 drops every hour, as directed by a healthcare provider . • Application Tips: o Wash hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If wearing contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: • Hypersensitivity to tobramycin or any component of the formulation . • Cautions: o Use with caution in pregnant or breastfeeding women; consult a healthcare provider before use . o Prolonged use may lead to the development of resistant bacteria. o Should not be used in children without medical supervision. ________________________________________

Timipar (Timolol Maleate 0.5%) Ophthalmic Solution is a prescription eye drop used to manage elevated intraocular pressure (IOP) in conditions such as open-angle glaucoma and ocular hypertension. By reducing the production of fluid within the eye, it helps lower IOP, thereby reducing the risk of optic nerve damage and potential vision loss. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common form of glaucoma where the drainage angle in the eye remains open, but the trabecular meshwork is partially blocked, leading to increased IOP. • Ocular Hypertension: A condition characterized by higher-than-normal IOP without any signs of glaucoma damage. ________________________________________ 💊 Dosage and Administration • Typical Dosage: Instill one drop of the 0.5% solution into the affected eye(s) twice daily. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. o After instilling the drop, gently press the corner of your eye (near the nose) for 1–2 minutes to prevent the medication from draining out. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Bronchial asthma or a history of bronchial asthma. o Severe chronic obstructive pulmonary disease (COPD). o Sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock. • Cautions: o Use with caution in patients with a history of heart disease, diabetes, or thyroid disorders, as beta-blockers can mask symptoms of hypoglycemia and hyperthyroidism. o Monitor for potential additive effects when used with other systemic beta-blockers. ________________________________________ 🧪 Mechanism of Action Timolol is a non-selective beta-adrenergic antagonist (beta-blocker) that reduces aqueous humor production in the eye, leading to a decrease in IOP. Its onset of action is typically within 20 minutes, with effects lasting up to 24 hours.

Timipar (Timolol Maleate 0.25%) eye drops are a prescription medication primarily used to manage elevated intraocular pressure (IOP) associated with conditions like open-angle glaucoma and ocular hypertension. By reducing the production of aqueous humor, the fluid inside the eye, Timolol helps lower IOP, thereby reducing the risk of optic nerve damage and potential vision loss . ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common type of glaucoma where the drainage angle in the eye remains open, but the trabecular meshwork is partially blocked, leading to increased IOP. • Ocular Hypertension: A condition characterized by higher-than-normal IOP without any signs of glaucoma damage. ________________________________________ 💊 Dosage and Administration • Typical Dosage: Instill one drop of the 0.25% solution into the affected eye(s) once or twice daily, as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them . ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Bronchial asthma or a history of bronchial asthma. o Severe chronic obstructive pulmonary disease (COPD). • Sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock . • Cautions: o Use with caution in patients with a history of heart disease, diabetes, or thyroid disorders, as beta-blockers can mask symptoms of hypoglycemia and hyperthyroidism. o Monitor for potential additive effects when used with other systemic beta-blockers . ________________________________________ 🧪 Mechanism of Action Timolol is a non-selective beta-adrenergic antagonist (beta-blocker) that reduces aqueous humor production in the eye, leading to a decrease in IOP. Its onset of action is typically within 20 minutes, with effects lasting up to 24 hours .