Timipar (Timolol Maleate 0.5%) Ophthalmic Solution is a prescription eye drop used to manage elevated intraocular pressure (IOP) in conditions such as open-angle glaucoma and ocular hypertension. By reducing the production of fluid within the eye, it helps lower IOP, thereby reducing the risk of optic nerve damage and potential vision loss. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common form of glaucoma where the drainage angle in the eye remains open, but the trabecular meshwork is partially blocked, leading to increased IOP. • Ocular Hypertension: A condition characterized by higher-than-normal IOP without any signs of glaucoma damage. ________________________________________ 💊 Dosage and Administration • Typical Dosage: Instill one drop of the 0.5% solution into the affected eye(s) twice daily. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. o After instilling the drop, gently press the corner of your eye (near the nose) for 1–2 minutes to prevent the medication from draining out. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Bronchial asthma or a history of bronchial asthma. o Severe chronic obstructive pulmonary disease (COPD). o Sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock. • Cautions: o Use with caution in patients with a history of heart disease, diabetes, or thyroid disorders, as beta-blockers can mask symptoms of hypoglycemia and hyperthyroidism. o Monitor for potential additive effects when used with other systemic beta-blockers. ________________________________________ 🧪 Mechanism of Action Timolol is a non-selective beta-adrenergic antagonist (beta-blocker) that reduces aqueous humor production in the eye, leading to a decrease in IOP. Its onset of action is typically within 20 minutes, with effects lasting up to 24 hours.

Timipar (Timolol Maleate 0.25%) eye drops are a prescription medication primarily used to manage elevated intraocular pressure (IOP) associated with conditions like open-angle glaucoma and ocular hypertension. By reducing the production of aqueous humor, the fluid inside the eye, Timolol helps lower IOP, thereby reducing the risk of optic nerve damage and potential vision loss . ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common type of glaucoma where the drainage angle in the eye remains open, but the trabecular meshwork is partially blocked, leading to increased IOP. • Ocular Hypertension: A condition characterized by higher-than-normal IOP without any signs of glaucoma damage. ________________________________________ 💊 Dosage and Administration • Typical Dosage: Instill one drop of the 0.25% solution into the affected eye(s) once or twice daily, as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them . ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Bronchial asthma or a history of bronchial asthma. o Severe chronic obstructive pulmonary disease (COPD). • Sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock . • Cautions: o Use with caution in patients with a history of heart disease, diabetes, or thyroid disorders, as beta-blockers can mask symptoms of hypoglycemia and hyperthyroidism. o Monitor for potential additive effects when used with other systemic beta-blockers . ________________________________________ 🧪 Mechanism of Action Timolol is a non-selective beta-adrenergic antagonist (beta-blocker) that reduces aqueous humor production in the eye, leading to a decrease in IOP. Its onset of action is typically within 20 minutes, with effects lasting up to 24 hours .

Nor-ADR Injection is a brand of Noradrenaline (Norepinephrine) Bitartrate Injection, manufactured by American Remedies. It is primarily used in critical care settings to manage severe hypotension (low blood pressure) and shock. ________________________________________ ✅ Primary Uses Nor-ADR Injection is indicated for: • Septic Shock: A life-threatening condition caused by severe infection leading to dangerously low blood pressure. • Cardiogenic Shock: A state where the heart is unable to pump sufficient blood to meet the body's needs. Anaphylactic Shock: A severe allergic reaction causing a sudden drop in blood pressure. • Hypotension During Surgery or Trauma: To maintain adequate blood pressure during and after surgical procedures or traumatic events. • Cardiac Arrest: As an adjunct in the management of cardiac arrest to improve blood flow to vital organs. These indications are supported by clinical guidelines and pharmacological references. ________________________________________ ⚙️ Mechanism of Action Noradrenaline is a potent vasopressor that works by: Alpha-1 Adrenergic Receptor Activation: Causing vasoconstriction, which increases systemic vascular resistance and raises blood pressure. • Beta-1 Adrenergic Receptor Activation: Increasing heart rate and myocardial contractility, thereby enhancing cardiac output. This dual action helps restore blood pressure and improve perfusion to vital organs in shock states. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Administration: Should be administered intravenously under strict medical supervision, typically in an intensive care unit (ICU) setting. • Monitoring: Continuous monitoring of blood pressure and heart rate is essential during administration. • Contraindications: Should not be used in patients with mesenteric or peripheral vascular thrombosis unless absolutely necessary. Common Side Effects: • Hypertension (high blood pressure) • Headache Nausea • Anxiety • Dizziness Serious Side Effects: • Arrhythmias (irregular heartbeats) • Tissue necrosis at the injection site • Reduced renal perfusion leading to renal failure Immediate medical attention is required if any serious side effects occur.

Nitrocan 25 Injection is a brand of Nitroglycerin Injection 25 mg/5 mL, manufactured by American Remedies. It is primarily used in hospital settings for the management of certain cardiovascular conditions. ________________________________________ ✅ Primary Uses Nitrocan 25 Injection is indicated for: • Angina Pectoris: To treat and prevent chest pain caused by reduced blood flow to the heart. • Acute Myocardial Infarction (Heart Attack): To alleviate chest pain and improve blood flow to the heart muscle. Hypertension During Surgery: To control high blood pressure during and after surgical procedures. • Congestive Heart Failure: To reduce the workload on the heart and improve symptoms. ________________________________________ ⚙️ Mechanism of Action Nitroglycerin is a nitrate that, once administered, is converted into nitric oxide in the body. This leads to the relaxation and dilation of blood vessels, improving blood flow and reducing the heart's workload. ________________________________________ ⚠️ Precautions • Contraindications: Should not be used in patients with severe anemia, hypotension, or those taking medications for erectile dysfunction (e.g., sildenafil, tadalafil) due to the risk of a significant drop in blood pressure. • Monitoring: Requires careful monitoring of blood pressure and heart rate during administration. • Administration: Administered intravenously under medical supervision; dosage and duration are determined by the healthcare provider. ________________________________________ 💊 Common Side Effects • Headache • Dizziness or lightheadedness • Hypotension (low blood pressure) • Nausea or vomiting • Flushing

Milrican 10 is a brand of Milrinone Lactate Injection, manufactured by American Remedies. Milrinone is a phosphodiesterase-3 (PDE3) inhibitor that serves as both an inotropic agent and a vasodilator. ________________________________________ ✅ Primary Uses of Milrican 10 Milrican 10 is indicated for the short-term intravenous treatment of: • Severe congestive heart failure: Particularly in patients unresponsive to conventional therapies. • Acute decompensated heart failure: Including low output states following cardiac surgery. It is commonly used in intensive care units or during cardiac procedures to support heart function. ________________________________________ ⚙️ Mechanism of Action Milrinone works by inhibiting PDE3, leading to increased cyclic AMP (cAMP) levels in cardiac and vascular smooth muscle cells. This results in: • Increased myocardial contractility: Enhancing the heart's ability to pump blood. • Vasodilation: Relaxing blood vessels, which reduces the heart's workload and improves blood flow. ________________________________________ ⚠️ Important Considerations • Administration: Milrican 10 should only be administered intravenously under the supervision of a healthcare professional. • Monitoring: Patients receiving Milrican 10 require close monitoring of blood pressure, heart rate, and kidney function. • Contraindications: Not recommended for patients with severe dehydration, electrolyte imbalances, or known hypersensitivity to milrinone. • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.

Nipress 50mg Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Nitroprusside (50mg) Storage Store below 30°C Uses of Nipress Injection Angina (heart-related chest pain) Heart Failure Coronary artery disease Hypertensive emergency Anal fissure Product introduction Nipress 50mg Injection is a medicine used in the immediate treatment of hypertensive emergency (severely increased blood pressure) and acute heart failure. It brings about an immediate reduction in blood pressure and the workload of the heart. Nipress 50mg Injection is given as a drip into the vein under the supervision of a doctor. Your doctor is the right person to decide the dose and duration, hence do not try to self-administered the injection at home. Regular monitoring of blood pressure is required while on treatment. Decreased blood pressure (hypotension) may occur as a side effect of this medicine. Inform your doctor if you are pregnant, planning to conceive or breastfeeding. It is also advisable to avoid medication like sildenafil or tadalafil while on treatment as it may cause a sudden lowering of blood pressure. Side effects of Nipress Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Nipress Cyanide poisoning Decreased blood pressure How to use Nipress Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Nipress Injection works Nipress 50mg Injection is a vasodilator. It works by relaxing the muscles in your blood vessels to help them widen and results in the lowering of blood pressure. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Nipress 50mg Injection. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Nipress 50mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. warnings Breast feeding CONSULT YOUR DOCTOR Nipress 50mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. warnings Driving CONSULT YOUR DOCTOR It is not known whether Nipress 50mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. warnings Kidney SAFE IF PRESCRIBED Nipress 50mg Injection is safe to use in patients with kidney disease. No dose adjustment of Nipress 50mg Injection is recommended. However, talk to your doctor if you have any underlying kidney disease.

Nitrocin 5ML Injection Marketer Samarth Life Sciences Pvt Ltd SALT COMPOSITION Nitroglycerin (5mg/ml) Salt Synonyms Glyceryl Trinitrate Storage Store below 30°C Uses of Nitrocin Injection Angina (heart-related chest pain) Heart Failure Treatment of Hypertension (high blood pressure) Coronary artery disease Hypertensive emergency Anal fissure Product introduction Nitrocin 5mg Injection is used to treat and prevent heart-related chest pain (angina) and hypertension (high blood pressure) during surgery. This medicine works by relaxing and widening blood vessels so blood can flow more easily to the heart. It has a very short-lived effect. Nitrocin 5mg Injection is given as an injection under the supervision of a doctor with careful blood pressure monitoring. This is given as a continuous infusion into a vein and should not be stopped abruptly. It should not be mixed with any other medication of any kind. The most common side effect of Nitrocin 5mg Injection is a headache which may be severe. This can sometimes be helped by drinking plenty of fluids and avoiding alcohol. You may also experience lightheadedness, which could increase your risk of having a fall. There are other, rarer side effects, some of them serious. Ask your doctor and read the leaflet which comes with the medicine to make sure you are keeping safe. Do not use Nitrocin 5mg Injection if you are taking medicines to treat high blood pressure in your lungs (pulmonary hypertension), or erectile dysfunction; or if you have anemia or glaucoma (increased pressure inside the eye). Always tell your doctor what other health conditions you have and what other medicines you are taking. It is best not to drink alcohol with this medicine as it increases some of the side effects. If you are affected by dizziness, avoid driving. If you are pregnant, thinking about becoming pregnant, or breastfeeding, ask your doctor before taking this medicine. Benefits of Nitrocin Injection In Treatment of Hypertension (high blood pressure) Nitrocin 5mg Injection is used to treat hypertension in hypertensive emergencies. It rapidly dilates (widens) the blood vessels. This rapid vasodilation helps reduce blood pressure levels, relieving the strain on the heart and improving blood flow to vital organs. It is typically used in critical situations where immediate blood pressure reduction is necessary, such as severe high blood pressure that can lead to organ damage or other life-threatening complications. Side effects of Nitrocin Injection Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Nitrocin Blurred vision Decreased blood pressure Dizziness Headache Increased heart rate Lightheadedness Paresthesia (tingling or pricking sensation) How to use Nitrocin Injection Your doctor or nurse will give you this medicine. Kindly do not self administer. How Nitrocin Injection works Nitrocin 5mg Injection is a nitrate. It works by improving blood supply to heart and relaxing the blood vessels which decreases the oxygen demand of the heart and reduces its workload, thereby preventing/treating attacks of angina (chest pain). Relaxation of blood vessels lowers blood pressure. Safety advice warnings Alcohol UNSAFE Consuming alcohol while taking Nitrocin 5mg Injection may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction). warnings Pregnancy SAFE IF PRESCRIBED Nitrocin 5mg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. warnings Breast feeding SAFE IF PRESCRIBED Nitrocin 5mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. warnings Driving UNSAFE Nitrocin 5mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. warnings Kidney SAFE IF PRESCRIBED Nitrocin 5mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Nitrocin 5mg Injection may not be needed in these patients. Please consult your doctor. warnings Liver CONSULT YOUR DOCTOR There is limited information available on the use of Nitrocin 5mg Injection in patients with liver disease. Please consult your doctor.

Dobier S 50mg Injection Salt: Dobutamine (50mg) INTRODUCTION ABOUT DOBIER S 50MG INJECTION DOBIER S 50MG INJECTION contains Dobutamine which belongs to the group of medicines called Cardiac Stimulants. It is used to improve heart functions. It restores heartbeat and blood pressure to normal levels among patients undergoing open heart surgery and in patients having heart failure or any other severe heart conditions that reduces heart rate (such as shock or cardiomyopathies (enlargement of heart muscles)). It can also be used as an alternative to exercise during stress testing (a procedure used to detect heart problems). DOBIER S 50MG INJECTION is suitable for use both in adults and in children (including infants). Before receiving DOBIER S 50MG INJECTION inform your doctor if you have asthma or any other respiratory disorders. You must also inform your doctor if you have any allergic conditions or low blood volume as a precaution. DOBIER S 50MG INJECTION is not suitable for stress testing in patients having any heart or blood vessels disorders that hinder blood flow. It is also not recommended for use in pregnant and in breastfeeding women unless considered necessary by the physician. The most common side effects of receiving DOBIER S 50MG INJECTION are fast heartbeat, headache, high or low blood pressure, shortness of breath, inflammation at the injection site, nausea and urge to pass urine. Consult your doctor if any of these side effects worsens. USES OF DOBIER S 50MG INJECTION Improves heart functions by restoring normal heartbeat and blood pressure Manage heart failure Manage shock (cardiogenic or septic shock) Manage any heart conditions that may result in poor circulation around the body (such as cardiomyopathies, open heart surgery) Used as an alternative to exercise during stress testing HOW DOBIER S 50MG INJECTION WORKS DOBIER S 50MG INJECTION is a cardiac stimulant. It stimulates the heart and improves heart functions. It helps your heart to work more effectively by strengthening the pumping action of the heart. It also improves blood circulation around the body by expanding the blood vessels present all over the body. DIRECTIONS FOR USE DOBIER S 50MG INJECTION will be given only by a doctor or by a trained healthcare professional into the vein (intravenously). Your doctor will decide the correct dose, duration of therapy and site of administration for you depending upon your age, body weight and health condition. SIDE EFFECTS OF DOBIER S 50MG INJECTION COMMON increased heart rate chest pain abnormal heartbeat, palpitations high or low blood pressure narrowing of the blood vessels headache wheezing, shortness of breath increase in WBC count in blood increased bleeding tendency urge to pass urine nausea skin rash fever inflammation at the injection site HOW TO MANAGE SIDE EFFECTS Headache: Try to take rest. Apply a pain-relieving balm on your forehead. If the symptom does not improve, consult with your doctor. Nausea: Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens. Skin rash: Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens. Inflammation at the site of injection: Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor. WARNING & PRECAUTIONS PREGNANCY DOBIER S 50MG INJECTION is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before receiving this medicine if you are pregnant or think you may be pregnant or planning to have a baby. BREASTFEEDING DOBIER S 50MG INJECTION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving this medicine if you are breastfeeding. DRIVING AND USING MACHINES Do not drive or operate any machines if your ability is affected by DOBIER S 50MG INJECTION. ALLERGY Do not receive DOBIER S 50MG INJECTION if you are allergic to Dobutamine. LUNGS DOBIER S 50MG INJECTION should be used with caution in patients with asthma or any allergic or respiratory conditions. Therefore, consult your doctor before receiving it. HEART DISEASE DOBIER S 50MG INJECTION is not recommended for use in patients who have narrowing of blood vessels supplying the heart (coronary artery stenosis) or other heart disorders. It should be used with caution in patients with other heart problems (such as coronary artery disease, or acute heart failure). Therefore, consult your doctor before receiving it. OTHERS DOBIER S 50MG INJECTION is not recommended for use if you: have low blood volume (hypovolaemia) have any disorders in the blood vessels that hinders blood flow Before receiving DOBIER S 50MG INJECTION, inform your physician if you:

INTRODUCTION ABALAM 600/300 is a combination of Abacavir and Lamivudine which belongs to the group of medicines called Anti-viral agents. It is used in the management of HIV infection in adults, adolescents and in children (weighing above 25 kgs). HIV (human immunodeficiency virus) infection is a viral infection that damages our immune system and weakens our body’s ability to fight against various infections. Both abacavir and lamivudine are nucleoside reverse transcriptase inhibitors. They work by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. This prevents further multiplication of viral cells within the body. Also, they can improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. ABALAM 600/300 cannot not manage HIV infection completely. It can reduce only the number of viral cells present in the body and maintains them at a lower level. During management with ABALAM 600/300 your doctor will closely monitor your body weight, blood cholesterol levels and blood sugar levels to reduce the risk of unwanted side effects. Do not take ABALAM 600/300 if you are allergic to abacavir or lamivudine. Before taking ABALAM 600/300 inform your doctor if you have diabetes or any liver (hepatitis C or B infection), kidney or heart problems. If you are already taking ABALAM 600/300 to manage hepatitis B or C infection, do not stop taking it without consulting your doctor. Even if you take ABALAM 600/300, it is important for you to follow certain measures to prevent the spread of infections to the other people (such as avoid having unprotected sexual intercourse or sharing needles or personal items like toothbrush, razors etc with other people). ABALAM 600/300 is not recommended for use in pregnant or breastfeeding women. The most common side effects of taking ABALAM 600/300 are difficulty in sleeping, increased signs of infections, nausea, stomach pain, headache, or dizziness. Consult your doctor if any of these side effects worsens. Also inform your doctor immediately if you experience severe fever with extreme tiredness, sudden changes in body weight or severe stomach pain along with dark urine after taking ABALAM 600/300. USES OF ABALAM 600/300 Manages HIV infection in adults, adolescents and in children (weighing above 25 kgs) HOW ABALAM 600/300 WORKS ABALAM 600/300 is an anti-retroviral medicine. It controls the multiplication of viral cell within the body, by blocking the actions of certain viral enzymes (HIV-reverse transcriptase) that is required for the viral cell to grow and multiply. It can also improve immunity in the affected patients by increasing the number of certain types of white blood cells (CD4) in the body which is required to fight against various infections. DIRECTIONS FOR USE Take ABALAM 600/300 as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. ABALAM 600/300 can be taken with or without meals. Your doctor will decide the correct dose and for how long ABALAM 600/300 must be taken depending upon your age, body weight and severity of the infection. Do not stop taking ABALAM 600/300 without consulting your doctor as it may reduce its effectiveness. SIDE EFFECTS OF ABALAM 600/300 COMMON difficulty in sleeping feeling depressed headache, tiredness, dizziness nausea, diarrhoea fever, skin rash stomach pain loss of appetite irritated or runny nose hair loss UNCOMMON decrease in RBC, WBC, and platelets RARE Stop taking ABALAM 600/300 and contact your doctor immediately if you experience any of the following side effects: signs of allergic reactions (such as skin rash, fever, accompanied with sore throat, cough, nausea, vomiting, stomach pain, diarrhea, tiredness, joint pain, muscle pain, swelling of the neck, difficulty in breathing, mouth ulcers, occasional headaches, inflammation of the eye, low blood pressure, sense of tingling or numbness of hands or feet) pure red cell aplasia (failure of bone marrow to produce new red blood cells) signs of infections (such as fever, headache, stomach-ache, breathing difficulty) signs of auto-immune disorders (such as rapid or irregular heartbeat, tremor, hyperactivity, general weakness) signs of osteonecrosis (death of bone cells causing joint stiffness, pain in the hip, knee or shoulder and difficulty in moving) signs of liver problems (such as yellowing of the skin and whites of the eye, dark urine, light-coloured stools, loss of appetite, nausea, pain, tenderness on the right side of stomach) heart attack changes in body fat (such as increase fat in the shoulder and neck (buffalo hump), breast, and in the middle body or fat loss from the legs, arms, or face)