INTRODUCTION ABOUT ENCORATE CHRONO 500MG TABLET ENCORATE CHRONO 500MG TABLET is a combination of Sodium valproate and Valproic acid, which belong to the group of medicines called Anticonvulsant/Antiepileptic drugs. It is used to manage epilepsy in adults and children. It is also used to manage bipolar disorders. Epilepsy is an abnormal electrical activity in the brain and nervous system. The symptoms may include temporary confusion, muscle stiffness, jerky movements in legs or arms, loss of consciousness, psychological symptoms (such as anxiety or fear), etc. ENCORATE CHRONO 500MG TABLET is not recommended for use in patients with liver problems or with a family history of liver problems, porphyria (a hereditary disease that affects the skin or nervous system), blood coagulation or clotting disorders, pancreatic diseases (inflammation of the pancreas), urea cycle disorder (a genetic disorder) or Alpers-Huttenlocher syndrome (a rare disorder that affects brain, liver & muscles), etc. ENCORATE CHRONO 500MG TABLET should be used with caution in patients with kidney problems or lung diseases (such as chronic obstructive pulmonary disease) and diabetes. ENCORATE CHRONO 500MG TABLET is also not recommended for use in pregnant and breastfeeding women. It should be used with caution in children (below 2 years of age). Consult your doctor before taking the medicine. The common side effects of taking ENCORATE CHRONO 500MG TABLET may include dizziness, headache, sleep disorders, clumsiness/unsteadiness, trembling of hands and arms and nervousness. Consult your doctor if any of the symptoms worsen or persist. USES OF ENCORATE CHRONO 500MG TABLET Manage epilepsy Manage bipolar disorders HOW ENCORATE CHRONO 500MG TABLET WORKS ENCORATE CHRONO 500MG TABLET helps in managing epilepsy, where sodium valproate and valproic acid effectively increases the GABA (a neurotransmitter/chemical messenger) concentration in the central nervous system by reducing its degradation. It also blocks certain ion channels which reduce high-frequency neuronal activity in the brain, thereby reliving seizure activity. DIRECTIONS FOR USE Take ENCORATE CHRONO 500MG TABLET as advised by your physician. Swallow the medicine with a glass of water with or after food. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition. SIDE EFFECTS OF ENCORATE CHRONO 500MG TABLET COMMON headache sleep disorders clumsiness or unsteadiness trembling of hands and arms nervousness changing moods blurred vision ringing in ears deafness dizziness flu abdominal or stomach pain heartburn nausea and vomiting diarrhoea skin rash hair loss or thinning of hair back pain change in menstrual periods lack or loss of strength mental confusion aggression convulsion memory problems becoming unreactive bedwetting signs of liver damage such as skin and eyes that appear yellowish (jaundice), abdominal pain and swelling. signs of inflammation of the pancreas (pancreatitis) such as upper abdominal pain, abdomen tenderness, fever and rapid pulse signs of Fanconi syndrome (a disorder of kidney tubes) such as excessive thirst, urination, vomiting overgrown gum tissue agitation disturbance in attention abnormal behaviour hyperactivity learning disorder UNCOMMON unusual bleeding or bruising abnormal dreams anxiety feeling sad irritability pain in joints cough constipation dry eyes spots before the eyes ear infection ear pain runny nose dental pain bloating muscle pains or stiffness tiredness weight gain or loss learning disorder coma loss of muscle control brittle bones and fractures shortness of breath chest pain blood clotting problems RARE Stop taking ENCORATE CHRONO 500MG TABLET and contact your doctor if you experience any of the following side effects: signs of allergic reactions such as swelling of the face, lips, eyelids, throat and tongue, which may cause difficulty in breathing and swallowing signs of altered levels of ammonia in the blood characterized by vomiting, balance issues and lack of alertness signs of liver problems characterized by nausea, vomiting, tiredness, sleepiness, weakness, stomach pain, yellowing of the skin or whites of the eye signs of inflammation of the pancreas characterized by acute abdominal pain chest pain shortness of breath hallucinations suicidal thoughts psychosis (mental disorder causing disconnection from reality) toxic epidermal necrolysis (life-threatening skin disorder causing widespread skin pain, rashes, blisters, sores and crusting) Steven-Johnson syndrome (a skin disorder characterized by painful rashes and blisters on the skin) anaphylaxis (severe allergic reaction characterized by shortness of breath, fainting or fastened heartbeat) erythema multiforme (a skin condition characterized by raised red rashes on the skin)

Aromacalm® is dedicated to dogs and cats prone to stress and stress-associated skin disorders. This collar helps calm your pets while soothing and hydrating their skin. Changes of environment (moving, adoption, cohabitation, separation…) Occasional situations (traveling, veterinay consultation, excessive noise…) The patented technology of Aromacalm® enables a continuous and constant diffusion of the ingredients during 1 month. A specific safety quick-release system specifically designed for cats will allow the Aromacalm® collar to enlarge and break in case of important tension.

Tropicamide Ophthalmic Solution USP 0.5% is a sterile, anticholinergic eye drop used primarily for diagnostic purposes in ophthalmology. ________________________________________ 🔍 Primary Uses 1. Pupillary Dilation (Mydriasis): Tropicamide 0.5% is employed to dilate the pupil, facilitating detailed examination of the retina, optic nerve, and other internal eye structures during procedures like fundoscopy and slit-lamp assessments. 2. Cycloplegia: It temporarily paralyzes the ciliary muscle, preventing accommodation (focusing), which is useful in refractive error assessments. 3. Management of Uveitis: Tropicamide 0.5% is utilized in treating conditions like acute and subacute iridocyclitis, chronic iridocyclitis, and to prevent adhesions and disruptions of the iris and ciliary body. ________________________________________ ⚠️ Side Effects While generally well-tolerated, potential side effects may include: • Temporary stinging or burning sensation upon instillation • Blurred vision • Sensitivity to light (photophobia) • Dry mouth • Headache • Nausea or vomiting • Pale skin • Central nervous system disturbances, including agitation or confusion, especially in pediatric patients ________________________________________ 🧪 Usage Instructions • Administration: Instill one or two drops into the affected eye(s) as directed by your healthcare provider. • Contact Lenses: Remove contact lenses before application. • Hygiene: Avoid touching the dropper tip to any surface to prevent contamination. • Post-application: Apply gentle pressure to the inner corner of the eye for 1–3 minutes to minimize systemic absorption. ________________________________________ ⚠️ Precautions • Driving and Operating Machinery: Avoid engaging in activities requiring clear vision, such as driving, until the effects of the medication have worn off. • Pediatric Use: Use with caution in children, as anticholinergic drugs may cause CNS disturbances. • Pregnancy and Breastfeeding: Consult your healthcare provider before use during pregnancy or while breastfeeding.

Tropind Plus is a combination ophthalmic solution containing Tropicamide 0.8% and Phenylephrine 5%. This formulation is primarily used for both diagnostic and therapeutic purposes in ophthalmology. 🩺 Primary Uses of Tropind Plus 1. Pupillary Dilation (Mydriasis): The combination of Tropicamide and Phenylephrine effectively dilates the pupil, allowing eye care professionals to conduct thorough examinations of the retina, optic nerve, and other internal structures. 2. Cycloplegia: Tropicamide paralyzes the ciliary muscle, preventing accommodation (focusing), which is useful in refractive error assessments. 3. Uveitis Management: In cases of uveitis, Tropind Plus helps alleviate pain and prevents further spasms of the eye muscles. 4. Preoperative Preparation: Before surgeries like cataract extraction or retinal procedures, dilating the pupil is essential for clear visualization of the posterior segment. 5. Retinal Imaging: Facilitates procedures such as fundus photography and optical coherence tomography (OCT) by ensuring adequate pupil dilation. ⚙️ How It Works • Tropicamide is a parasympatholytic agent that inhibits the contraction of the circular muscle and paralyzes the ciliary muscle, leading to pupil dilation and cycloplegia. Phenylephrine is a sympathomimetic drug that causes contraction of the radial muscle of the iris, contributing to pupil dilation. Together, these agents produce rapid and effective dilation of the pupil, facilitating detailed eye examinations and procedures. ⚠️ Side Effects Common side effects may include: • Eye pain or stinging • Blurred vision • Sensitivity to light (photophobia) • Allergic reactions These effects are typically temporary and resolve shortly after the examination. 🧪 Safety and Precautions • Driving and Operating Machinery: Avoid activities that require clear vision, such as driving, immediately after application, as the solution can cause temporary blurred vision. • Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or while breastfeeding, as safety data may be limited. • Drug Interactions: Be cautious when using Tropind Plus with certain medications, especially monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants, as interactions may occur.

Biotrav (Travoprost) Ophthalmic Solution Biotrav is a prescription eye drop containing travoprost, a prostaglandin analog used to lower intraocular pressure (IOP) in individuals with open-angle glaucoma or ocular hypertension. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common type of glaucoma characterized by gradual loss of vision due to increased IOP. • Ocular Hypertension: Elevated IOP without optic nerve damage, which can lead to glaucoma if untreated. ________________________________________ 💊 Dosage and Administration • Recommended Dosage: Instill one drop into the affected eye(s) once daily in the evening. • Application Tips: o Wash hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to travoprost or any component of the formulation. o Active or suspected ocular infections. o History of hypersensitivity to prostaglandin analogs. • Cautions: o Use with caution in patients with a history of uveitis, macular edema, or retinal vein occlusion. o May cause changes in eye color, eyelash growth, and skin pigmentation around the eyes. o Consult a healthcare provider before use if pregnant, planning to become pregnant, or breastfeeding. ________________________________________ 🧪 Mechanism of Action Travoprost works by increasing the outflow of aqueous humor through the trabecular meshwork and uveoscleral pathways, thereby reducing IOP. This helps prevent damage to the optic nerve and loss of vision associated with glaucoma and ocular hypertension.

Biotrav-T (Travoprost and Timolol Maleate) Ophthalmic Solution is a prescription eye drop used to manage elevated intraocular pressure (IOP) in individuals with open-angle glaucoma or ocular hypertension. It combines two medications—travoprost (a prostaglandin analog) and timolol maleate (a non-selective beta-blocker)—to reduce IOP through complementary mechanisms. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common form of glaucoma characterized by gradual loss of vision due to increased IOP. • Ocular Hypertension: Elevated IOP without optic nerve damage, which can lead to glaucoma if untreated. ________________________________________ 💊 Dosage and Administration • Recommended Dosage: Instill one drop into the affected eye(s) once daily, preferably in the evening. • Application Tips: o Wash hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Active or suspected ocular infections. o History of hypersensitivity to beta-blockers. • Cautions: o Use with caution in patients with cardiovascular or pulmonary diseases, as timolol may exacerbate conditions like asthma, bradycardia, or heart block. o Monitor for potential systemic absorption effects, including hypotension or bradycardia. o Consult a healthcare provider before use if pregnant, planning to become pregnant, or breastfeeding. ________________________________________

Tobi-D (Tobramycin with Dexamethasone) Eye Drops is a prescription ophthalmic solution combining an antibiotic and a corticosteroid to treat specific bacterial eye infections accompanied by inflammation. ________________________________________ ✅ Primary Uses Tobi-D is primarily used for: • Bacterial Conjunctivitis: Infection of the conjunctiva (the membrane covering the white part of the eye and the inner surface of the eyelids). • Keratitis: Infection of the cornea. • Post-surgical Infections: Prophylactic treatment or management of infections following eye surgeries. It addresses both the infection and the inflammation associated with these conditions. ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye(s) every 4–6 hours, or as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Contraindications and Cautions • Contraindications: o Hypersensitivity to tobramycin, dexamethasone, or any component of the formulation. o Active viral infections of the eye, such as herpes simplex keratitis. o Untreated fungal or mycobacterial infections of the eye. • Cautions: o Use with caution in patients with a history of glaucoma, as corticosteroids can increase intraocular pressure. o Prolonged use may lead to cataract formation or secondary ocular infections. o Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. ________________________________________ 🧪 Mechanism of Action • Tobramycin: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, leading to bacterial cell death. • Dexamethasone: A corticosteroid that reduces inflammation by inhibiting the release of inflammatory mediators. Together, these components address both the infection and the inflammation associated with certain eye conditions.

Tobi-F (Tobramycin Sulphate and Fluorometholone) Ophthalmic Solution is a prescription eye drop that combines an antibiotic and a corticosteroid to treat specific eye conditions. ________________________________________ ✅ Primary Uses Tobi-F is primarily used to manage inflammatory eye conditions where a steroid is indicated and where there is a risk of or existing superficial bacterial infection. The combination of tobramycin and fluorometholone addresses both the infection and the inflammation. ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye(s) every 4–6 hours, or as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Contraindications and Cautions • Contraindications: o Hypersensitivity to tobramycin, fluorometholone, or any component of the formulation. o Active viral infections of the eye, such as herpes simplex keratitis. • Untreated fungal or mycobacterial infections of the eye. • Cautions: o Use with caution in patients with a history of glaucoma, as corticosteroids can increase intraocular pressure. o Prolonged use may lead to cataract formation or secondary ocular infections. o Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Tobi (Tobramycin Ophthalmic Solution) is a prescription antibiotic eye drop used to treat bacterial infections of the eye. It contains 0.3% tobramycin, a broad-spectrum aminoglycoside antibiotic effective against various gram-positive and gram-negative bacteria. ________________________________________ ✅ Primary Uses • Bacterial Conjunctivitis: Infection of the conjunctiva (the membrane covering the white part of the eye and the inner surface of the eyelids). • Blepharitis: Inflammation of the eyelid margins, often associated with bacterial infection. • Keratitis: Infection of the cornea. • Post-surgical Infections: Prophylactic treatment or management of infections following eye surgeries. Tobramycin ophthalmic solution is typically used alone or in combination with other medications, depending on the severity and type of infection . ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye every 4 hours during the day. • Severe Infections: In some cases, the dosage may be increased to 2 drops every hour, as directed by a healthcare provider . • Application Tips: o Wash hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If wearing contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: • Hypersensitivity to tobramycin or any component of the formulation . • Cautions: o Use with caution in pregnant or breastfeeding women; consult a healthcare provider before use . o Prolonged use may lead to the development of resistant bacteria. o Should not be used in children without medical supervision. ________________________________________