Nor-ADR Injection is a brand of Noradrenaline (Norepinephrine) Bitartrate Injection, manufactured by American Remedies. It is primarily used in critical care settings to manage severe hypotension (low blood pressure) and shock. ________________________________________ ✅ Primary Uses Nor-ADR Injection is indicated for: • Septic Shock: A life-threatening condition caused by severe infection leading to dangerously low blood pressure. • Cardiogenic Shock: A state where the heart is unable to pump sufficient blood to meet the body's needs. Anaphylactic Shock: A severe allergic reaction causing a sudden drop in blood pressure. • Hypotension During Surgery or Trauma: To maintain adequate blood pressure during and after surgical procedures or traumatic events. • Cardiac Arrest: As an adjunct in the management of cardiac arrest to improve blood flow to vital organs. These indications are supported by clinical guidelines and pharmacological references. ________________________________________ ⚙️ Mechanism of Action Noradrenaline is a potent vasopressor that works by: Alpha-1 Adrenergic Receptor Activation: Causing vasoconstriction, which increases systemic vascular resistance and raises blood pressure. • Beta-1 Adrenergic Receptor Activation: Increasing heart rate and myocardial contractility, thereby enhancing cardiac output. This dual action helps restore blood pressure and improve perfusion to vital organs in shock states. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Administration: Should be administered intravenously under strict medical supervision, typically in an intensive care unit (ICU) setting. • Monitoring: Continuous monitoring of blood pressure and heart rate is essential during administration. • Contraindications: Should not be used in patients with mesenteric or peripheral vascular thrombosis unless absolutely necessary. Common Side Effects: • Hypertension (high blood pressure) • Headache Nausea • Anxiety • Dizziness Serious Side Effects: • Arrhythmias (irregular heartbeats) • Tissue necrosis at the injection site • Reduced renal perfusion leading to renal failure Immediate medical attention is required if any serious side effects occur.

Nitrocan 25 Injection is a brand of Nitroglycerin Injection 25 mg/5 mL, manufactured by American Remedies. It is primarily used in hospital settings for the management of certain cardiovascular conditions. ________________________________________ ✅ Primary Uses Nitrocan 25 Injection is indicated for: • Angina Pectoris: To treat and prevent chest pain caused by reduced blood flow to the heart. • Acute Myocardial Infarction (Heart Attack): To alleviate chest pain and improve blood flow to the heart muscle. Hypertension During Surgery: To control high blood pressure during and after surgical procedures. • Congestive Heart Failure: To reduce the workload on the heart and improve symptoms. ________________________________________ ⚙️ Mechanism of Action Nitroglycerin is a nitrate that, once administered, is converted into nitric oxide in the body. This leads to the relaxation and dilation of blood vessels, improving blood flow and reducing the heart's workload. ________________________________________ ⚠️ Precautions • Contraindications: Should not be used in patients with severe anemia, hypotension, or those taking medications for erectile dysfunction (e.g., sildenafil, tadalafil) due to the risk of a significant drop in blood pressure. • Monitoring: Requires careful monitoring of blood pressure and heart rate during administration. • Administration: Administered intravenously under medical supervision; dosage and duration are determined by the healthcare provider. ________________________________________ 💊 Common Side Effects • Headache • Dizziness or lightheadedness • Hypotension (low blood pressure) • Nausea or vomiting • Flushing

Milrican 10 is a brand of Milrinone Lactate Injection, manufactured by American Remedies. Milrinone is a phosphodiesterase-3 (PDE3) inhibitor that serves as both an inotropic agent and a vasodilator. ________________________________________ ✅ Primary Uses of Milrican 10 Milrican 10 is indicated for the short-term intravenous treatment of: • Severe congestive heart failure: Particularly in patients unresponsive to conventional therapies. • Acute decompensated heart failure: Including low output states following cardiac surgery. It is commonly used in intensive care units or during cardiac procedures to support heart function. ________________________________________ ⚙️ Mechanism of Action Milrinone works by inhibiting PDE3, leading to increased cyclic AMP (cAMP) levels in cardiac and vascular smooth muscle cells. This results in: • Increased myocardial contractility: Enhancing the heart's ability to pump blood. • Vasodilation: Relaxing blood vessels, which reduces the heart's workload and improves blood flow. ________________________________________ ⚠️ Important Considerations • Administration: Milrican 10 should only be administered intravenously under the supervision of a healthcare professional. • Monitoring: Patients receiving Milrican 10 require close monitoring of blood pressure, heart rate, and kidney function. • Contraindications: Not recommended for patients with severe dehydration, electrolyte imbalances, or known hypersensitivity to milrinone. • Pregnancy and Breastfeeding: Consult a doctor before use if pregnant or breastfeeding.

Alpostin 500mcg Injection Salt: Alprostadil (500mcg) Description Alpostin 500mcg Injection is used to treat patent ductus arteriosus (PDA), a heart defect that occurs in newborns. It improves blood circulation in such babies and helps treat this defect. Alpostin 500mcg Injection is used to treat patent ductus arteriosus (PDA), a heart defect that occurs in newborns. It improves blood circulation in such babies and helps treat this defect. Alpostin 500mcg Injection is given as an injection by a doctor or nurse and should not be used without medical supervision. The most common side effects of this medicine are interrupted breathing (apnea) and a high temperature for a short time period (transient pyrexia/fever). If your baby has these or any other side effects, let your doctor know. All babies can have Alpostin 500mcg Injection if they need it. The doctor will carry out tests before deciding whether to give this medicine to your baby. However, if your baby develops any signs of allergy to this medicine, such as wheezing, breathlessness, swelling of the face, hands, itchy rash, or redness of the skin, it is advised to not use this medicine. Consult your doctor if you have any doubts. Benefits 1. In Treatment of Patent ductus arteriosus (PDA): Patent ductus arteriosus (PDA) is a persistent opening between the two major blood vessels leading from the heart. Usually this opening closes shortly after birth, but it can remain open and lead to this heart defect in babies. Alpostin 500mcg Injection improves blood flow in such babies who have PDA. It is given as an injection by a doctor or nurse in a hospital setup. Follow your doctor’s instructions carefully to get the most benefit. Side Effects Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Common side effects of Alpostin: - Apnea (absence of breathing) - Fever

Prostal 500mcg Injection Salt Composition : Alprostadil Manufacturer : CELON LABORATORIES LTD Introduction to Prostal 500mcg Injection Prostal 500mcg injection contains active components called Alprostadil. This medication is often used to treat ED in men with difficulty achieving or maintaining an erection. It may be used to improve blood flow in patients with peripheral arterial disease (PAD), a condition in which blood flow to the extremities (usually the legs) is reduced. In newborns with certain heart conditions, such as PDA, it can open a blood vessel called the ductus arteriosus. It can also be used in diagnostic tests to assess blood flow in specific body areas, such as during penile Doppler ultrasound studies to evaluate erectile function. Individuals who have a known allergy or hypersensitivity to Alprostadil or any of its components should not use the medication. It should be avoided in men with penile implants or conditions that make penile injections unsafe, such as penile fibrosis, curvature, or priapism (prolonged erections). It should not be used in individuals with conditions predisposing them to priapism, such as sickle cell anemia, multiple myeloma, or leukemia. It should not be used in individuals who experience unexplained genital or pelvic pain, as it may indicate an underlying medical condition. Individuals with bleeding disorders or those taking anticoagulant medications (blood thinners) should use Prostal 500mcg injection cautiously, as it may increase the risk of bleeding at the injection site. It should not be used concomitantly with alpha-blocker medications used to treat conditions like benign prostatic hyperplasia (BPH) and high blood pressure, as it can lead to severe low blood pressure. It should not be used in infants with congenital heart defects who have conditions that are worsened by increased blood flow to the lungs. It can be used in elderly patients, but caution may be required. Uses of Prostal 500mcg Injection Erectile dysfunction (ED) Peripheral arterial disease (PAD) Patent ductus arteriosus (PDA) in Infants Diagnostic testing Therapeutic Effects of Prostal 500mcg Injection Prostal 500mcg injection binds to specific receptors on smooth muscle cells in blood vessels and various tissues. When it binds to these receptors, it triggers biochemical events that lead to vasodilation. It relaxes the smooth muscles in blood vessel walls, particularly in the penis, when used for erectile dysfunction. It involves promoting the relaxation of smooth muscle cells, improving blood flow to specific body areas, depending on its intended use. Interaction of Prostal 500mcg Injection with other drugs Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Prostal 500mcg injection, reducing effectiveness by causing undesirable side effects. More Information about Prostal 500mcg Injection Store at room temperature below 20 to 25°C Keep away from moisture, heat, and light. It should not be frozen. Keep away from children and pets. How to consume Prostal 500mcg Injection Prostal 500mcg injection can be administered via various routes, depending on the medical condition. For erectile dysfunction (ED), it can be injected directly into the penis (intracavernosal injection), applied topically to the penile tip (urethral application), or used as a urethral suppository. Safety Advices for Prostal 500mcg Injection Image Not Available Pregnancy If you are pregnant or trying to become pregnant, it is important to talk to your doctor before taking Prostal 500mcg injection. Image Not Available Breast Feeding There is limited research on the safety of Prostal 500mcg injection in breastfeeding women. It is important to talk to your doctor before taking this medication. Image Not Available Lungs If you have lung diseases, talking to your doctor before taking Prostal 500mcg injection is important. Image Not Available Liver Prostal 500mcg injection is metabolized in the liver, so individuals with severe liver disease may require dose adjustments. Patients with liver problems should discuss their condition with their healthcare provider before using it. Image Not Available Alcohol It is unsafe to drink alcohol while taking Prostal 500mcg injection. Excessive alcohol consumption can increase the risk of certain side effects. Image Not Available Driving Prostal 500mcg injection can cause dizziness or fainting, especially if low blood pressure occurs. If you experience any side effects, consult your healthcare provider before taking it while driving. Side Effects of Prostal 500mcg Injection Prostal 500mcg injection causes some side effects like all medications, although not everyone will experience them. Serious: Priapism Penile fibrosis Allergic reactions Low blood pressure Cardiovascular effects Bleeding Common:

Dobier S 50mg Injection Salt: Dobutamine (50mg) INTRODUCTION ABOUT DOBIER S 50MG INJECTION DOBIER S 50MG INJECTION contains Dobutamine which belongs to the group of medicines called Cardiac Stimulants. It is used to improve heart functions. It restores heartbeat and blood pressure to normal levels among patients undergoing open heart surgery and in patients having heart failure or any other severe heart conditions that reduces heart rate (such as shock or cardiomyopathies (enlargement of heart muscles)). It can also be used as an alternative to exercise during stress testing (a procedure used to detect heart problems). DOBIER S 50MG INJECTION is suitable for use both in adults and in children (including infants). Before receiving DOBIER S 50MG INJECTION inform your doctor if you have asthma or any other respiratory disorders. You must also inform your doctor if you have any allergic conditions or low blood volume as a precaution. DOBIER S 50MG INJECTION is not suitable for stress testing in patients having any heart or blood vessels disorders that hinder blood flow. It is also not recommended for use in pregnant and in breastfeeding women unless considered necessary by the physician. The most common side effects of receiving DOBIER S 50MG INJECTION are fast heartbeat, headache, high or low blood pressure, shortness of breath, inflammation at the injection site, nausea and urge to pass urine. Consult your doctor if any of these side effects worsens. USES OF DOBIER S 50MG INJECTION Improves heart functions by restoring normal heartbeat and blood pressure Manage heart failure Manage shock (cardiogenic or septic shock) Manage any heart conditions that may result in poor circulation around the body (such as cardiomyopathies, open heart surgery) Used as an alternative to exercise during stress testing HOW DOBIER S 50MG INJECTION WORKS DOBIER S 50MG INJECTION is a cardiac stimulant. It stimulates the heart and improves heart functions. It helps your heart to work more effectively by strengthening the pumping action of the heart. It also improves blood circulation around the body by expanding the blood vessels present all over the body. DIRECTIONS FOR USE DOBIER S 50MG INJECTION will be given only by a doctor or by a trained healthcare professional into the vein (intravenously). Your doctor will decide the correct dose, duration of therapy and site of administration for you depending upon your age, body weight and health condition. SIDE EFFECTS OF DOBIER S 50MG INJECTION COMMON increased heart rate chest pain abnormal heartbeat, palpitations high or low blood pressure narrowing of the blood vessels headache wheezing, shortness of breath increase in WBC count in blood increased bleeding tendency urge to pass urine nausea skin rash fever inflammation at the injection site HOW TO MANAGE SIDE EFFECTS Headache: Try to take rest. Apply a pain-relieving balm on your forehead. If the symptom does not improve, consult with your doctor. Nausea: Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens. Skin rash: Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens. Inflammation at the site of injection: Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor. WARNING & PRECAUTIONS PREGNANCY DOBIER S 50MG INJECTION is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before receiving this medicine if you are pregnant or think you may be pregnant or planning to have a baby. BREASTFEEDING DOBIER S 50MG INJECTION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving this medicine if you are breastfeeding. DRIVING AND USING MACHINES Do not drive or operate any machines if your ability is affected by DOBIER S 50MG INJECTION. ALLERGY Do not receive DOBIER S 50MG INJECTION if you are allergic to Dobutamine. LUNGS DOBIER S 50MG INJECTION should be used with caution in patients with asthma or any allergic or respiratory conditions. Therefore, consult your doctor before receiving it. HEART DISEASE DOBIER S 50MG INJECTION is not recommended for use in patients who have narrowing of blood vessels supplying the heart (coronary artery stenosis) or other heart disorders. It should be used with caution in patients with other heart problems (such as coronary artery disease, or acute heart failure). Therefore, consult your doctor before receiving it. OTHERS DOBIER S 50MG INJECTION is not recommended for use if you: have low blood volume (hypovolaemia) have any disorders in the blood vessels that hinders blood flow Before receiving DOBIER S 50MG INJECTION, inform your physician if you:

Dopacan Injection is a brand of Dopamine Hydrochloride, a potent vasopressor and inotropic agent used in critical care settings to manage various cardiovascular conditions. It is administered intravenously under medical supervision. ________________________________________ 🩺 Medical Uses Dopacan Injection is indicated for: • Shock Management: Including septic shock, cardiogenic shock, and hypovolemic shock. • Acute Heart Failure: To improve cardiac output and perfusion. • Severe Hypotension: Especially in patients unresponsive to volume resuscitation. • Renal Protection: To enhance renal blood flow and urine output in certain critically ill patients. Dopamine works by stimulating dopaminergic and beta-adrenergic receptors, leading to increased heart rate, contractility, and renal perfusion. At higher doses, it also stimulates alpha-adrenergic receptors, causing vasoconstriction and increased blood pressure. ________________________________________ ⚙️ Dosage and Administration Dopacan Injection is administered intravenously, with the dosage tailored to the patient's condition and response: • Low Dose (1–5 mcg/kg/min): Primarily stimulates dopaminergic receptors, increasing renal blood flow and urine output. • Medium Dose (5–15 mcg/kg/min): Stimulates beta-1 adrenergic receptors, enhancing heart rate and contractility. • High Dose (15–50 mcg/kg/min): Stimulates alpha-1 adrenergic receptors, leading to vasoconstriction and increased blood pressure. Continuous monitoring of blood pressure, heart rate, and urine output is essential during administration. ________________________________________ ⚠️ Precautions and Contraindications Before using Dopacan Injection, inform your healthcare provider if you have: • Allergies to dopamine or other components of the injection. • A history of heart rhythm disorders or coronary artery disease. • Pheochromocytoma (a rare tumor of the adrenal glands). • Diabetes, asthma, or sulfite allergies. • Circulatory disorders such as Raynaud's disease or Buerger's disease. • Recent use of monoamine oxidase inhibitors (MAOIs). This medication is typically administered by healthcare professionals in a clinical setting and is not intended for self-administration. ________________________________________ 💊 Side Effects Common side effects may include: • Palpitations or increased heart rate. • Nausea and vomiting. • Headache. • Difficulty breathing. • Gangrene (in rare cases, due to excessive vasoconstriction). Serious side effects are rare but can occur. Seek immediate medical attention if you experience symptoms like chest pain, shortness of breath, or signs of gastrointestinal bleeding.

Bisomax 5 Tablet is used to manage heart failure, particularly in patients recovering from a heart attack. It also treats high blood pressure (hypertension), angina (chest pain), and arrhythmia (irregular rhythms). It improves heart function, reduces strain, and lowers the risk of future cardiac events. Bisomax 5 Tablet helps improve cardiac output and prevent heart failure progression. It helps regulate blood pressure, enhances blood flow, and supports overall cardiovascular health. This makes it essential to post-myocardial infarction (heart attack) care, ensuring long-term heart protection. It may also be used to relieve the symptoms caused by an overactive thyroid gland. Your doctor may prescribe Bisomax 5 Tablet as part of a comprehensive heart care plan, often alongside lifestyle modifications like a heart-healthy diet, regular exercise, and smoking cessation. It is important to take Bisomax 5 Tablet exactly as directed by your doctor. Do not stop taking this medication without consulting your doctor, as sudden discontinuation may increase heart risks.

Top Avana is a prescription medication manufactured by Sunrise Remedies, combining two active ingredients: • Avanafil (50 mg): A phosphodiesterase type 5 (PDE5) inhibitor that enhances blood flow to the penis during sexual stimulation, aiding in achieving and maintaining an erection. • Dapoxetine (30 mg): A selective serotonin reuptake inhibitor (SSRI) that delays ejaculation, helping to manage premature ejaculation. ________________________________________ ✅ Primary Uses Top Avana is prescribed for men experiencing: 1. Erectile Dysfunction (ED): Difficulty in achieving or maintaining an erection sufficient for sexual activity. 2. Premature Ejaculation (PE): Ejaculation that occurs sooner than desired during sexual activity By addressing both conditions simultaneously, Top Avana enhances sexual performance and satisfaction. ________________________________________ ⚙️ How It Works • Avanafil: Inhibits PDE5, leading to increased levels of cyclic GMP, which relaxes smooth muscle and dilates blood vessels in the penis, facilitating an erection during sexual arousal. • Dapoxetine: Increases serotonin levels in the brain, which helps delay ejaculation and improves control over ejaculation timing. ________________________________________ ⏱️ Dosage and Administration • Recommended Dosage: One tablet (50 mg Avanafil + 30 mg Dapoxetine) taken orally. • Timing: Approximately 30 to 60 minutes before planned sexual activity. • Administration: Swallow the tablet whole with a glass of water. It can be taken with or without food. • Frequency: Do not exceed one tablet per day. ________________________________________ ⚠️ Precautions and Warnings • Contraindications: Avoid use if allergic to Avanafil, Dapoxetine, or any other components of the tablet. • Cardiovascular Health: Consult a healthcare provider if you have a history of heart disease, stroke, or low blood pressure. • Drug Interactions: Avoid concomitant use with nitrates, riociguat, or other PDE5 inhibitors. • Other Conditions: Inform your doctor if you have liver or kidney impairment, eye disorders like retinitis pigmentosa, or are taking other medications. ________________________________________ 🌡️ Possible Side Effects • Common Side Effects: Headache, dizziness, flushing, nasal congestion, indigestion, and visual disturbances. • Serious Side Effects: Seek immediate medical attention if you experience symptoms such as fainting, vision disturbances, or allergic reactions. ________________________________________ 📌 Important Note Top Avana is intended for use under the supervision of a healthcare professional. It is not FDA-approved for the treatment of sexual dysfunction in women, and its use should be considered only after a thorough evaluation by a doctor. If you have further questions or need more detailed information about Top Avana, please consult with a healthcare provider or pharmacist.