BIOFENAC Diclofenac Sodium USP is an anti-inflammatory eye drop used primarily to treat eye conditions that involve pain, swelling, and inflammation. It contains Diclofenac Sodium, which is a nonsteroidal anti-inflammatory drug (NSAID). 🔹 Primary Uses Post-Operative Inflammation BIOFENAC is commonly used after eye surgeries, such as cataract surgery, to help reduce inflammation and pain. Ocular Pain Relief It helps alleviate pain and discomfort caused by conditions like post-traumatic inflammation or other inflammatory eye conditions. Keratitis Treatment for inflammation of the cornea (keratitis), which can occur due to injury, infection, or other conditions. Conjunctivitis (inflammation of the conjunctiva) Can be used to manage eye inflammation caused by allergic reactions or other irritants. 🔹 How It Works Diclofenac Sodium is an NSAID that works by inhibiting the production of certain chemicals in the body known as prostaglandins, which are responsible for causing inflammation, pain, and swelling. By blocking these chemicals, BIOFENAC helps reduce inflammation and provides pain relief. ⚠️ Common Side Effects Stinging or burning upon application Eye irritation or redness Temporary blurred vision Dry eyes or feeling of a foreign body in the eye Sensitivity to light (photophobia) 🔹 Usage Tips Frequency: Typically used 2-4 times a day, depending on your doctor's recommendations, especially after surgery or for controlling inflammation. Application: Wash your hands before using the drops. Tilt your head back and pull down your lower eyelid to form a small pocket. Instill 1 drop into the pocket without touching the dropper to your eye. Gently close your eye and blink a few times to spread the medication evenly. If you need to use multiple eye medications, wait about 5–10 minutes between applications. Contact Lenses: Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them. 🔹 Precautions Eye Infections: Diclofenac may mask the symptoms of an eye infection. If you have an eye infection, consult your doctor before using this medication. Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding, as NSAIDs may not be recommended in some cases. Allergies: If you have a history of allergic reactions to NSAIDs, aspirin, or other related medications, let your doctor know before using BIOFENAC. Long-Term Use: Prolonged use of NSAIDs can increase the risk of corneal damage or other complications, so it should be used with caution for extended periods.

CYCLOSIM 0.1% Eye Drops contain Cyclosporine A, which is an immunosuppressive drug. These eye drops are primarily used for conditions related to dry eyes and inflammation. Here's a detailed overview of its uses: 🔹 Primary Uses Treatment of Dry Eye Disease (Keratoconjunctivitis Sicca) Cyclosporine A in CYCLOSIM 0.1% is commonly used to treat dry eye disease associated with inflammation. It helps by increasing tear production and reducing the inflammation in the eye, making it useful for those who have chronic dry eye caused by insufficient tear production. Inflammatory Eye Conditions It can help reduce inflammation in the eyes, particularly in conditions where the immune system is involved in causing eye irritation or dry eye symptoms. 🔹 How It Works Cyclosporine A is an immunosuppressive agent that modulates the immune system by inhibiting the production of certain cytokines (especially interleukin-2). In the context of dry eyes, this helps to reduce inflammation in the tear glands and promotes tear production. ⚠️ Common Side Effects Burning or stinging sensation in the eye upon application Redness in the eye Eye discomfort or feeling of a foreign object in the eye Watery eyes Temporary blurred vision (typically resolves shortly after application) 🔹 Usage Tips Frequency: Typically applied twice a day, about 12 hours apart, in each affected eye. Application: Wash your hands thoroughly before using the drops. Tilt your head back and pull down the lower eyelid to form a small pocket. Instill 1 drop into the pocket of the lower eyelid. Close your eye gently and blink several times to help spread the medication. If you use other eye medications, wait at least 5–10 minutes between applications. Contact Lenses: Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting. 🔹 Precautions Infections: If you have an active eye infection, this medication may not be appropriate as it could exacerbate it. Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding before using Cyclosporine A eye drops. Other Medications: Always inform your doctor if you are using other eye medications or oral medications that may interact with Cyclosporine.

INTRODUCTION ABOUT RITUXIREL 100 INJECTION RITUXIREL 100 INJECTION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals). It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). RITUXIREL 100 INJECTION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion). Before receiving RITUXIREL 100 INJECTION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. RITUXIREL 100 INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving RITUXIREL 100 INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with RITUXIREL 100 INJECTION. The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens. USES OF RITUXIREL 100 INJECTION It is used to manage: Blood cancer (Chronic lymphocytic leukaemia) Lymph cancer (Non-Hodgkin’s Lymphoma) Rheumatoid arthritis (joint pain and inflammation) Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals) HOW RITUXIREL 100 INJECTION WORKS RITUXIREL 100 INJECTION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases. DIRECTIONS FOR USE RITUXIREL 100 INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RITUXIREL 100 INJECTION COMMON increased infections (bacterial, viral or fungal) low RBC, WBC and platelet counts in blood nausea, vomiting, diarrhea, stomach pain, constipation, indigestion mouth ulcers hair loss fever, chills, pneumonia, shingles, cold, sinusitis thrush, urinary tract infection headache, dizziness, tiredness, weakness hepatitis B infection high blood sugar and cholesterol levels weight loss, lack of appetite numbness, tingling, pricking, burning sensation on the skin restlessness, problems in falling asleep, anxiety, depression flushing (skin redness) eye inflammation or watery eyes ringing sound in the ears, ear pain uneven or fast heart rate, high or low blood pressure shortness of breath, runny nose, nasal itching and repeated sneezing increased sweating, night sweats muscle pain, joint pain, back pain, neck pain pain while passing urine fungal foot infection (athlete’s foot) tremors (shakiness) swelling of the hands or ankles UNCOMMON blood clotting problems changes in taste slow heart rate chest tightness and lung problems RARE Contact your doctor immediately if you experience any of the following side effects: fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems) signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever)

INTRODUCTION ABOUT RITUXIREL 500MG INJECTION RITUXIREL 500MG INJECTION contains Rituximab which belongs to the group of medicines called Anticancer drugs. It is used to manage blood cancer (leukaemia) and lymph cancer (lymphoma). It can also be used to manage various auto-immune disease conditions such as rheumatoid arthritis, granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) and pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals). It is mostly used in combination with other cytotoxic anticancer agents to achieve better results. It is suitable for use both in adults and in children (aged 6 months or older). RITUXIREL 500MG INJECTION will be administered to you only by an oncologist or a trained professional into your vein (as intravenous infusion). Before receiving RITUXIREL 500MG INJECTION inform your doctor if you have any heart problems (such as chest pain, heart attack, heart failure or abnormal heartbeat). You must also inform your doctor if you currently have or previously had hepatitis B infection or any other mild infections (including minor cough and cold) as a precaution. RITUXIREL 500MG INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women receiving RITUXIREL 500MG INJECTION must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with RITUXIREL 500MG INJECTION. The most common side effects of receiving this medicine are fever, chills, skin rashes with itching, shortness of breath and low blood pressure. Consult your doctor if any of these side effect worsens. USES OF RITUXIREL 500MG INJECTION It is used to manage: Blood cancer (Chronic lymphocytic leukaemia) Lymph cancer (Non-Hodgkin’s Lymphoma) Rheumatoid arthritis (joint pain and inflammation) Granulomatosis with polyangiitis or microscopic polyangiitis (inflammation of blood vessels) Pemphigus vulgaris (severe skin blistering and peeling especially on the mouth, nose, throat, eyes and genitals) HOW RITUXIREL 500MG INJECTION WORKS RITUXIREL 500MG INJECTION is a monoclonal antibody. It destroys the immune cells (B-cells) that triggers cancer formation. It also reduces the production of certain chemicals within the body (such as rheumatoid factor, T-cells, cytokines) that causes inflammation, pain and swelling which helps in managing various autoimmune diseases. DIRECTIONS FOR USE RITUXIREL 500MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF RITUXIREL 500MG INJECTION COMMON increased infections (bacterial, viral or fungal) low RBC, WBC and platelet counts in blood nausea, vomiting, diarrhea, stomach pain, constipation, indigestion mouth ulcers hair loss fever, chills, pneumonia, shingles, cold, sinusitis thrush, urinary tract infection headache, dizziness, tiredness, weakness hepatitis B infection high blood sugar and cholesterol levels weight loss, lack of appetite numbness, tingling, pricking, burning sensation on the skin restlessness, problems in falling asleep, anxiety, depression flushing (skin redness) eye inflammation or watery eyes ringing sound in the ears, ear pain uneven or fast heart rate, high or low blood pressure shortness of breath, runny nose, nasal itching and repeated sneezing increased sweating, night sweats muscle pain, joint pain, back pain, neck pain pain while passing urine fungal foot infection (athlete’s foot) tremors (shakiness) swelling of the hands or ankles UNCOMMON blood clotting problems changes in taste slow heart rate chest tightness and lung problems RARE Contact your doctor immediately if you experience any of the following side effects: fever, chills, shivering, nausea, vomiting, skin rashes with blisters and itching, flushing, pain at the infusion site, headache, tiredness, wheezing, high blood pressure, palpitations, swelling of throat or tongue, runny or itchy nose and chest pain fever, cough, sore throat, burning pain while passing urine, feeling weak or generally unwell signs of brain problem (such as memory loss, trouble thinking, difficulty in walking or vision problems) signs of severe skin reactions (such as severe skin blistering and redness that may appear on the on the mucous membranes, such as inside the mouth, the genital areas or the eyelids, with fever) HOW TO MANAGE SIDE EFFECTS Constipation Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.

Cyclomune 0.05% About the brand Cyclomune is brand of Sun Pharmaceuticals having salt Cyclosporine. Sun Pharmaceuticals is one of biggest generic drug manufacturer throughout global markets. It has served more than 150 markets globally. It has more than 2000 marketed products and is the leading pharmaceutical drug company of India. About the drug Cyclomune is drug having Cyclosporine as salt. Cyclosporine eye drops work differently as compared to cyclosporine used in different dosage forms. Cyclosporine is an immunosuppressant drug. It interferes with the immune system of the body. Cyclosporine eye drops help in curing the dry eye condition when used as an ophthalmic solution. Manufacturer of the drug Cyclomune is manufactured by Sun Pharmaceutical in India. Strength of the drug The 3 ml solution of Cyclomune contains 0.5 % strength of Cyclosporine. USA equivalent brand Restasis is the US brand equivalent to Cyclomune available in USA markets. Uses of the drug Cyclomune is used for dry eye conditions. It has proven effects to cure chronic dry eye conditions. How does it work? As an eye drop, Cyclomune works as a partial modulator of the immune system. Tear production in the eyes gets lowered due to the accumulation of dead lymphocytes cells in tear glands. Cyclomune eye drops works by reversing the cycle and hence helps in increasing the tear production from tear glands. How to take the drug? Take the medicine as directed by your physician. It should be taken twice in a day with a gap of 12 hours in between in both eyes. Efforts shall be made to take the drug drops the same time every day. Dosage needed Cyclomune eye drops shall be taken twice in a day. For correct dosage take your physician advice and guidelines. How long should drug to be continued? It shall be continued as directed by your doctor. Do not overdose yourself with the eye drops. What if you miss the dosage? Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not instill a double dose to make up for a missed one. Drug interaction with other More than 800 drug interactions have been reported with use of Cyclosporine. It interacts with atorvastatin, aspirin, Calcium 600 D, docusate, amlodipine, pregabalin, Zyrtec etc. When not to take the drug Avoid taking the drug if you are allergic to any of the constituents of the drug Cyclomune. Consult your doctor for further advise. Side effects of intake Side effects associated with the drug are, burning, itching, stinging, redness, or pain of the eyes overflow of tears red eyes eye discharge blurred vision or other vision changes feeling that something is in the eye Overdose effects Shaking, headache, dizziness, unusual growth of body hair, nausea/vomiting, diarrhea, stomach upset, flushing or Unusual growth and swelling of the gums may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. General information and precautions Do not let anyone else use your medication. Ask your pharmacist any doubts you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. carry this list with you every time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

About Bimat 0.03% wv It is an effective treatment for Open Angle Glaucoma and eyelash development. Bimatoprost is included in BIMAT 0.03% wv as its active ingredient. Ajanta Pharmaceuticals manufactures these popular eye drops. Uses of Bimat 0.03% wv 0.03% wv solution of Bimat is used in the following conditions: Open-Angle Glaucoma Glaucoma is a group of disorders that affect a person's eyes. Open-Angle Glaucoma is the most prevalent, painless condition that causes vision loss and irreversible blindness. Intraocular pressure increases at an alarming rate in Open-Angle Glaucoma, resulting in vision loss. Bimat, 0.03% wv, aids in treating Open-Angle Glaucoma by lowering intraocular pressure. Hypotrichosis Hypotrichosis is a disorder in which hair development slows or hair loss occurs in a specific body area. Bimat eye drops have been demonstrated to aid in repairing hair in the eye area, primarily eyelashes, when used by patients. How does the drug work? The major element in Bimat 0.03% wv is Bimatoprost. These eye drops are primarily to aid in opening clogged drainage pathways in the eye area. The intraocular pressure gets reduced when the eye's drainage channels are opened. It is because the extra fluid in the inner space of the eye is discharged. The active ingredient Bimatoprost is an FDA-approved salt. It is also available as alternative medicines like Careprost 3 ml. of 0.03% and Lumigan 3 ml (of 0.03%). How to take the drug? The drops should be put in one eye at a time, with caution Pull the lower eyelid down with your index finger and make a pocket in the eye. Close and open the eyelid to disperse the medication across the ocular area. Use only one drop each day, and follow the doctor's instructions. To treat Hypotrichosis, gently apply the drop with an applicator to the root of the upper eyelashes region. It is normally advised to take one dose per day. But, you should strictly follow the doctor's prescription for the proper doses. In case you miss any dose, skip it and continue with the usual schedule of your dose. Do not double the dose or overdose yourself. For better results, try taking medicine at the same time every day. Side Effects of BIMAT 0.03% wv The following are some of the side effects of taking BIMAT eye drops: Eye dryness Watering eyes Itchy eyes Discomfort in the eyes Burning feeling in the eyes Changes in eyesight Blurred vision Interactions Drug Interactions Other Prostaglandins Ophthalmic medications like Latanoprost, Tafluprost, Travoprost, and Unoprostone may interact with this drug Food Interactions Non-prescription drugs, vitamins, nutritional supplements, and herbal items you are taking or intend to use may interact with Bimat 0.03% Disease Interactions If you have had renal or liver problems, Uveitis (eye inflammation), or Macular Edema (fluid buildup in the eye resulting in swelling), tell your doctor Precautions to be taken You should avoid the usage of solution in the following cases: Wearing contact lenses: You should remove the contact lenses before using eye drops. You can wear the contact lenses back after 2 hours of application Consumed Alcohol: Intake of Alcohol with Bimat 0.03%wv can adversely affect your liver Pregnant or planning on conceiving: The eyedrops can affect the fetus or pregnant women Allergic to Bimatoprost Experiencing discomfort in your eye Suffering from headaches Storage Store the drug away from sunlight and in a cool and dry place. Frequently Asked Questions What happens if I stop using Bimat 0.03% wv? The eyelashes may revert to their previous state after several weeks or months if you stop using Bimat Eye Drop. If you have noticed any eyelid skin darkening, it might go away after a few weeks or months. How long does it take for Bimat 0.03 % wv to take effect? Bimat Eye Drops may begin working within 4 hours of dosing. Is Bimatoprost safe to use? Bimatoprost is an FDA-approved salt and can be effectively used to treat Open-angle Glaucoma and Hypotrichosis.

HYLA FRESH (Sodium Hyaluronate) Eye Drops are designed to provide relief for dry, tired, or irritated eyes. These drops combine sodium hyaluronate with Euphrasia officinalis (Eyebright) extract, offering a soothing effect for various eye discomforts. ________________________________________ 🔍 Uses • Dry Eye Relief: HYLA FRESH helps alleviate dryness caused by environmental factors such as air conditioning, heating, or prolonged screen time. • Contact Lens Comfort: Provides lubrication to reduce discomfort associated with contact lens wear. Environmental Irritation: Soothes eyes irritated by wind, dust, or pollen exposure. Post-Surgical Care: Assists in the healing process following eye surgeries by maintaining moisture and reducing irritation. ________________________________________ 💧 Dosage and Administration • General Dosage: Instill 1–2 drops into the affected eye(s) as needed. • Application Method: 1. Wash your hands thoroughly. 2. Tilt your head back and gently pull down the lower eyelid to create a small pocket. 3. Place the dropper tip near the eye without touching it. 4. Squeeze the bottle to release the prescribed number of drops. 5. Close your eye and blink several times to spread the solution evenly. ________________________________________ ⚠️ Side Effects and Precautions • Common Side Effects: o Temporary blurred vision. o Mild burning or stinging sensation upon application. • Serious Side Effects: o Persistent eye discomfort or redness. o Signs of an allergic reaction (rash, itching, swelling). • Precautions: o Consult a healthcare provider before use if you have any known allergies to the ingredients. o Avoid touching the dropper tip to any surface to prevent contamination. o If you wear contact lenses, remove them before applying the drops unless otherwise directed by your doctor.

Povar (Povidone Iodine) Eye Drops are antiseptic ophthalmic solutions primarily used for preoperative and postoperative eye care, as well as for certain eye infections. The active ingredient, povidone-iodine, is a broad-spectrum antimicrobial agent effective against bacteria, viruses, and fungi. ________________________________________ 🔍 Uses of Povidone Iodine Eye Drops 1. Preoperative Antisepsis Applied to the ocular surface before eye surgeries such as cataract or glaucoma procedures to reduce the risk of postoperative infections. 2. Postoperative Care Used after eye surgeries to prevent infection and promote healing of the ocular surface. 3. Treatment of Conjunctivitis In some cases, povidone-iodine eye drops are used to treat bacterial or viral conjunctivitis, commonly known as pink eye. 4. Prevention of Ophthalmia Neonatorum Instilled in newborns' eyes shortly after birth to prevent gonococcal or chlamydial eye infections. ________________________________________ ⚠️ Safety and Side Effects • Common Side Effects Temporary stinging or burning sensation upon application. Mild irritation or redness of the eye. Temporary yellow discoloration of the whites of the eyes or surrounding skin. Serious Side Effects Signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing. If any of these occur, seek immediate medical attention. Precautions o Do not use if allergic to iodine or any components of the product. o Use with caution in individuals with thyroid disorders due to potential iodine absorption. o Not recommended for use in infants under one month of age. o Avoid concurrent use with other antiseptic eye drops containing mercury-based preservatives or sodium thiosulfate.

Blink Plus (Polyethylene & Propylene Glycol) Ophthalmic Solution is an over-the-counter eye drop formulation designed to provide relief for dry or irritated eyes. Here's an overview of its uses, dosage, side effects, and safety considerations: ________________________________________ 🔍 Uses Blink Plus combines two lubricating agents: • Polyethylene Glycol 400 (0.4%): Acts as a lubricant to relieve dryness and irritation by providing moisture to the eyes. It creates a protective layer on the eye's surface, reducing discomfort and enhancing tear film stability. Propylene Glycol (0.3%): Functions as a solvent and humectant, helping to dissolve and stabilize the active ingredients while attracting moisture to the eye, aiding in hydration and alleviating dryness. This combination is used to treat dry eye symptoms caused by environmental factors such as wind, sun, air conditioning, or prolonged screen time. ________________________________________ 💧 Dosage and Administration • General Dosage: Instill one or two drops into the affected eye(s) as needed. • Application Method: 1. Wash your hands thoroughly before use. 2. Tilt your head back slightly and pull down the lower eyelid to form a pouch. 3. Hold the dropper above the eye and instill the prescribed number of drops. 4. Close the eye gently and apply gentle pressure to the inner corner of the eye for 1 to 2 minutes to prevent the medication from draining away. 5. Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. ________________________________________ ⚠️ Safety and Side Effects • Common Side Effects: o Temporary blurred vision. o Mild burning or stinging sensation upon application. o Eye discomfort or irritation. • Redness or watering of the eyes. • Serious Side Effects: o Persistent eye pain or swelling. o Allergic reactions such as rash, itching, swelling, or severe dizziness. • Precautions: o Consult your doctor if you are pregnant or breastfeeding, as the safety of Blink Plus during these periods is not well-established. o Use with caution if you have a history of eye infections or other eye conditions. o Avoid driving or operating machinery if you experience blurred vision or visual disturbances.