Marketer Steadfast Medishield Pvt Ltd SALT COMPOSITION Valganciclovir (450mg) Storage Store below 30°C Uses of Valstead Tablet Treatment of Cytomegalovirus Infection Herpes labialis Genital herpes infection Chickenpox Herpes Simplex Virus Infections Eye infections by Herpes simplex virus Chronic hepatitis C virus (HCV) infection Product introduction Valstead 450mg Tablet is used to treat cytomegalovirus (CMV) infection of the retina (retinitis) in adult patients with acquired immunodeficiency syndrome (AIDS). It is also used for the prevention of CMV infection in patients who have received an organ transplant from a CMV-infected donor. Valstead 450mg Tablet should be taken in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. It should be taken with food. If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. You should drink plenty of water while on treatment with this medicine as it helps to prevent dehydration and kidney damage. It may lead to a few common side effects like fever, diarrhea, vomiting, anemia, low white blood cell, and low platelet level. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding. Benefits of Valstead Tablet In Treatment of Cytomegalovirus Infection Cytomegalovirus infection is a common virus infection which may have no symptoms at all or may have symptoms like fever and fatigue. Severe infection may show symptoms involving the eyes, brain, or other internal organs. This virus is spread through sexual and nonsexual contact with body secretions in people who are immunocompromised or those who have undergone any transplant. Valstead 450mg Tablet helps to prevent multiplication of the infection causing virus and treats the infection. Keep taking it in the dose and duration prescribed by the doctor to get maximum benefit. Side effects of Valstead Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Valstead Diarrhea Fever Vomiting Anemia (low number of red blood cells) Decreased white blood cell count Low blood platelets Insomnia (difficulty in sleeping) Tremors How to use Valstead Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Valstead 450mg Tablet is to be taken with food. How Valstead Tablet works Valstead 450mg Tablet is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

Clocivir 500 Injection is an intravenous formulation containing Acyclovir 500 mg, manufactured by American Remedies. It is primarily used to treat severe viral infections caused by herpes viruses. ________________________________________ 🩺 Uses of Clocivir 500 Injection Clocivir 500 Injection is indicated for: • Herpes Simplex Infections in Immunocompromised Patients: Including severe primary or non-primary genital herpes. • Herpes Simplex Encephalitis: A serious brain infection caused by the herpes simplex virus. • Neonatal Herpes Simplex Virus Infection: In newborns. • Varicella-Zoster Infections in Immunocompromised Patients: Such as severe cases of chickenpox or shingles. • Severe Herpes Zoster (Shingles): In immunocompetent patients with very severe acute local or systemic manifestations. ________________________________________ 💊 Mechanism of Action Acyclovir, the active ingredient in Clocivir, is a synthetic purine nucleoside analogue. It exerts its antiviral effects by inhibiting viral DNA synthesis, thereby preventing the replication of herpes viruses. Acyclovir is converted to its active form, Acyclovir Triphosphate, within infected cells, which then interferes with viral DNA polymerase. ________________________________________ ⚠️ Precautions • Administration: Clocivir 500 Injection should be administered by a healthcare professional through slow intravenous infusion over a 1-hour period to minimize the risk of kidney damage. • Hydration: Adequate hydration is essential during treatment to prevent dehydration and kidney damage. • Kidney Function: Use with caution in patients with pre-existing kidney conditions. • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Clocivir 250 Injection is an intravenous formulation containing Acyclovir 250 mg, manufactured by American Remedies. It is primarily used to treat severe viral infections caused by herpes viruses. ________________________________________ 🩺 Uses of Clocivir 250 Injection Clocivir 250 Injection is indicated for: • Herpes Simplex Virus Infections: Including severe cases in immunocompromised patients. • Genital Herpes: Especially primary or non-primary severe cases. • Herpes Zoster (Shingles): In immunocompetent patients with severe manifestations. • Chickenpox (Varicella Zoster Virus Infection): Particularly in immunocompromised individuals. • Herpes Simplex Encephalitis: A severe brain infection caused by the herpes simplex virus. ________________________________________ 💊 Mechanism of Action Acyclovir, the active ingredient in Clocivir, is a synthetic purine nucleoside analogue. It exerts its antiviral effects by inhibiting viral DNA synthesis, thereby preventing the replication of herpes viruses. Acyclovir is converted to its active form, Acyclovir Triphosphate, within infected cells, which then interferes with viral DNA polymerase . ________________________________________ ⚠️ Precautions • Administration: Clocivir 250 Injection should be administered by a healthcare professional through slow intravenous infusion over a 1-hour period to minimize the risk of kidney damage . • Hydration: Adequate hydration is essential during treatment to prevent dehydration and kidney damage. • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding. • Drug Interactions: Inform your healthcare provider about all other medications you are taking to avoid potential interactions.

Vetachlor-M contains the anti-fungal agent Miconazole and the antiseptic Chlorhexidine. While miconazole provides relief from dermatological conditions associated with fungal infections like ringworm, superficial skin infections, chlorhexidine is a broad-spectrum antimicrobial with demonstrated activity against both gram-positive and gram-negative bacteria, yeasts, and viruses. Vetachlor-M is indicated for the fungal infections and dermatitis associated with Staphylococcus intermedius, Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes.

Tobi-D (Tobramycin with Dexamethasone) Eye Drops is a prescription ophthalmic solution combining an antibiotic and a corticosteroid to treat specific bacterial eye infections accompanied by inflammation. ________________________________________ ✅ Primary Uses Tobi-D is primarily used for: • Bacterial Conjunctivitis: Infection of the conjunctiva (the membrane covering the white part of the eye and the inner surface of the eyelids). • Keratitis: Infection of the cornea. • Post-surgical Infections: Prophylactic treatment or management of infections following eye surgeries. It addresses both the infection and the inflammation associated with these conditions. ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye(s) every 4–6 hours, or as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Contraindications and Cautions • Contraindications: o Hypersensitivity to tobramycin, dexamethasone, or any component of the formulation. o Active viral infections of the eye, such as herpes simplex keratitis. o Untreated fungal or mycobacterial infections of the eye. • Cautions: o Use with caution in patients with a history of glaucoma, as corticosteroids can increase intraocular pressure. o Prolonged use may lead to cataract formation or secondary ocular infections. o Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. ________________________________________ 🧪 Mechanism of Action • Tobramycin: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, leading to bacterial cell death. • Dexamethasone: A corticosteroid that reduces inflammation by inhibiting the release of inflammatory mediators. Together, these components address both the infection and the inflammation associated with certain eye conditions.

Tobi-F (Tobramycin Sulphate and Fluorometholone) Ophthalmic Solution is a prescription eye drop that combines an antibiotic and a corticosteroid to treat specific eye conditions. ________________________________________ ✅ Primary Uses Tobi-F is primarily used to manage inflammatory eye conditions where a steroid is indicated and where there is a risk of or existing superficial bacterial infection. The combination of tobramycin and fluorometholone addresses both the infection and the inflammation. ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye(s) every 4–6 hours, or as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Contraindications and Cautions • Contraindications: o Hypersensitivity to tobramycin, fluorometholone, or any component of the formulation. o Active viral infections of the eye, such as herpes simplex keratitis. • Untreated fungal or mycobacterial infections of the eye. • Cautions: o Use with caution in patients with a history of glaucoma, as corticosteroids can increase intraocular pressure. o Prolonged use may lead to cataract formation or secondary ocular infections. o Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Povar (Povidone Iodine) Eye Drops are antiseptic ophthalmic solutions primarily used for preoperative and postoperative eye care, as well as for certain eye infections. The active ingredient, povidone-iodine, is a broad-spectrum antimicrobial agent effective against bacteria, viruses, and fungi. ________________________________________ 🔍 Uses of Povidone Iodine Eye Drops 1. Preoperative Antisepsis Applied to the ocular surface before eye surgeries such as cataract or glaucoma procedures to reduce the risk of postoperative infections. 2. Postoperative Care Used after eye surgeries to prevent infection and promote healing of the ocular surface. 3. Treatment of Conjunctivitis In some cases, povidone-iodine eye drops are used to treat bacterial or viral conjunctivitis, commonly known as pink eye. 4. Prevention of Ophthalmia Neonatorum Instilled in newborns' eyes shortly after birth to prevent gonococcal or chlamydial eye infections. ________________________________________ ⚠️ Safety and Side Effects • Common Side Effects Temporary stinging or burning sensation upon application. Mild irritation or redness of the eye. Temporary yellow discoloration of the whites of the eyes or surrounding skin. Serious Side Effects Signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing. If any of these occur, seek immediate medical attention. Precautions o Do not use if allergic to iodine or any components of the product. o Use with caution in individuals with thyroid disorders due to potential iodine absorption. o Not recommended for use in infants under one month of age. o Avoid concurrent use with other antiseptic eye drops containing mercury-based preservatives or sodium thiosulfate.

Loto-M belongs to a group of medications called ‘Antibiotics and Corticosteroids’ used to treat bacterial eye infections or eye discomfort. It is also used in patients who have undergone eye surgeries. It is used to treat eye inflammation caused by allergies, shingles, iritis (inflammation of the coloured part of the eye (iris)), uveitis (inflammation of the middle layer of the eye (uvea)), eye injury, radiation, and chemical burns. A bacterial eye infection occurs when bacteria invade any part of the eyeball or its surrounding tissues, including the cornea (clear front surface of the eye) and the conjunctiva (thin membrane lining the outer eye and inner eyelids). Loto-M is used to prevent or treat only bacterial eye infections. It does not work against infections caused by viruses and fungus.

Hepcvel Tablet is a combination of two antiviral medicines. This prescription medicine is used in the treatment of chronic hepatitis C virus (HCV) infection. It fights against the viruses to resolve the infection. Hepcvel Tablet should be taken in the prescribed dose and duration. It can be taken with or without food, but take it at the same time daily. It is advised not to consume more than the recommended dose. It is important to inform your doctor if you have any health conditions such as liver or kidney disease. It is harmful to consume alcohol along with this medicine, so it is advised to limit or avoid alcohol. The course of the medicine should be completed for better results. The common side effects of this medicine include fatigue, anemia, nausea, headache, insomnia, and diarrhea. You should drink plenty of fluid and eat a healthy diet to prevent or overcome the side effects. Before taking the medicine, inform your doctor if you are taking any other medicines or supplements.