Nor-ADR Injection is a brand of Noradrenaline (Norepinephrine) Bitartrate Injection, manufactured by American Remedies. It is primarily used in critical care settings to manage severe hypotension (low blood pressure) and shock. ________________________________________ ✅ Primary Uses Nor-ADR Injection is indicated for: • Septic Shock: A life-threatening condition caused by severe infection leading to dangerously low blood pressure. • Cardiogenic Shock: A state where the heart is unable to pump sufficient blood to meet the body's needs. Anaphylactic Shock: A severe allergic reaction causing a sudden drop in blood pressure. • Hypotension During Surgery or Trauma: To maintain adequate blood pressure during and after surgical procedures or traumatic events. • Cardiac Arrest: As an adjunct in the management of cardiac arrest to improve blood flow to vital organs. These indications are supported by clinical guidelines and pharmacological references. ________________________________________ ⚙️ Mechanism of Action Noradrenaline is a potent vasopressor that works by: Alpha-1 Adrenergic Receptor Activation: Causing vasoconstriction, which increases systemic vascular resistance and raises blood pressure. • Beta-1 Adrenergic Receptor Activation: Increasing heart rate and myocardial contractility, thereby enhancing cardiac output. This dual action helps restore blood pressure and improve perfusion to vital organs in shock states. ________________________________________ ⚠️ Precautions and Side Effects Precautions: • Administration: Should be administered intravenously under strict medical supervision, typically in an intensive care unit (ICU) setting. • Monitoring: Continuous monitoring of blood pressure and heart rate is essential during administration. • Contraindications: Should not be used in patients with mesenteric or peripheral vascular thrombosis unless absolutely necessary. Common Side Effects: • Hypertension (high blood pressure) • Headache Nausea • Anxiety • Dizziness Serious Side Effects: • Arrhythmias (irregular heartbeats) • Tissue necrosis at the injection site • Reduced renal perfusion leading to renal failure Immediate medical attention is required if any serious side effects occur.

Dobutacan 12 Injection is a brand of Dobutamine Hydrochloride 12.5 mg/mL, a synthetic catecholamine used in critical care settings to support heart function. It is administered intravenously under medical supervision. ________________________________________ 🩺 Medical Uses Dobutacan 12 Injection is indicated for: • Cardiac Decompensation: Acute heart failure due to conditions like myocardial infarction, cardiomyopathies, or post-cardiac surgery. • Cardiogenic Shock: A state of low cardiac output leading to inadequate tissue perfusion. • Septic Shock: A severe infection causing low blood pressure and organ dysfunction. • Stress Echocardiography: As a pharmacological agent to assess coronary artery disease when exercise is not feasible. It works by stimulating beta-1 adrenergic receptors, increasing heart contractility and stroke volume, thereby improving cardiac output. ________________________________________ ⚙️ Dosage and Administration Dobutacan 12 Injection is administered intravenously in a hospital setting. The typical dosage ranges from 2.5 to 10 mcg/kg/min, adjusted based on the patient's response. In some cases, doses up to 20 mcg/kg/min may be required. ________________________________________ ⚠️ Precautions and Contraindications Before using Dobutacan 12 Injection, inform your healthcare provider if you have: • Allergies to dobutamine or other components of the injection. • A history of arrhythmias or heart disease. • Kidney or liver problems. • A history of stroke or blood clots. This medication is typically administered by healthcare professionals in a clinical setting and is not intended for self-administration. It is usually given as an intramuscular (IM) or intravenous (IV) injection. ________________________________________ 💊 Side Effects Common side effects may include: • Headache • Nausea or vomiting • Dizziness or lightheadedness • Injection site reactions (pain, redness, or swelling) Serious side effects are rare but can occur. Seek immediate medical attention if you experience symptoms like chest pain, shortness of breath, or signs of gastrointestinal bleeding.

Amioron Injection is a prescription medication primarily used to manage serious cardiac arrhythmias, particularly life-threatening ventricular arrhythmias. ________________________________________ 🩺 Primary Uses • Ventricular Fibrillation (VF): A life-threatening irregular heart rhythm originating in the ventricles. • Ventricular Tachycardia (VT): A rapid heart rate originating from the ventricles, which may be unstable and require immediate treatment. Amioron is classified as a Class III antiarrhythmic agent and works by inhibiting certain electrical impulses in the heart, thereby stabilizing the heart rhythm. ________________________________________ ⚠️ Side Effects Common side effects may include: • Injection site reactions (pain, redness, swelling) • Dizziness or lightheadedness • Fatigue • Nausea Serious side effects can occur, including prolonged QT interval, hypotension, or worsening arrhythmias. Regular monitoring by healthcare professionals is essential during treatment. ________________________________________ 💊 Administration Amioron Injection is administered intravenously under strict medical supervision, typically in a hospital or emergency care setting. The dosage and duration depend on the specific cardiac condition and patient response. ________________________________________ ⚠️ Precautions • Inform your doctor if you have a history of thyroid disorders, liver disease, or respiratory issues. • Regular ECG monitoring is recommended during treatment. Use during pregnancy or breastfeeding should be discussed with a healthcare provider

Magnesium Chloride Injection is a sterile solution used to treat or prevent magnesium deficiency and related conditions. It's typically given when oral magnesium supplements are ineffective or inappropriate (e.g., in emergencies or hospitalized patients). 🔹 Main Uses of Magnesium Chloride Injection: 🧪 Treatment of Hypomagnesemia (Low Magnesium Levels) Used when blood magnesium levels drop too low, which can cause muscle cramps, fatigue, tremors, and arrhythmias. Common in alcoholics, diabetics, or those with malabsorption syndromes. 🫀 Cardiac Arrhythmias Especially effective in treating: Torsades de pointes (a type of ventricular tachycardia) Irregular heartbeats due to magnesium deficiency. 🤰 Eclampsia and Pre-eclampsia (Pregnancy-related Seizures) Magnesium sulfate is more commonly used, but magnesium chloride may be considered as an alternative. 💨 Severe Asthma Attacks (Adjunct Therapy) Can help relax bronchial smooth muscle and improve breathing during status asthmaticus when other treatments fail. ⚕️ Electrolyte Imbalance Correction Often used with other electrolytes (like potassium) in critical care settings to restore balance in ICU patients. 💉 How It's Given: Intravenously (IV) or Intramuscularly (IM) by a healthcare professional. Dosage depends on the severity of magnesium deficiency or the condition being treated. ⚠️ Precautions & Side Effects: Monitor serum magnesium levels to avoid overdose. High levels can cause: Low blood pressure Flushing Muscle weakness Slow heart rate Respiratory depression or cardiac arrest in severe overdose Use with caution in patients with kidney disease, as magnesium is excreted by the kidneys. ✅ Summary: Condition Use of MgCl Injection Hypomagnesemia ✅ Yes Torsades de Pointes ✅ Yes Pre-eclampsia / Eclampsia ✅ Alternative (to MgSO₄) Severe Asthma (adjunct) ✅ Yes Routine supplementation ⚠️ Only in hospital/clinical setting

Disodium Edetate Injection (also written as EDTA Disodium or Disodium EDTA) is a chelating agent with very limited and specific medical uses due to the risk of serious side effects. 🔹 Approved Medical Uses of Disodium Edetate Injection: 🔻 Treatment of Severe Hypercalcemia Primary use: Treats life-threatening high calcium levels in the blood. It binds to excess calcium ions and helps remove them from the body via the kidneys. 💊 Digitalis (Digoxin) Toxicity (rare/adjunct) In cases of digoxin overdose, disodium EDTA may be used to lower calcium, which worsens digoxin's toxic effects. ⚠️ NOT for Lead Poisoning ⚠️ Very important: Disodium EDTA is not used for lead poisoning. It can dangerously lower blood calcium and cause fatal hypocalcemia. The safe version for lead chelation is Calcium Disodium EDTA (CaNa₂EDTA). 💉 How It’s Given: Intravenously (IV) and must be administered slowly. Requires monitoring of calcium and kidney function. ⚠️ Risks and Side Effects: Severe hypocalcemia (can cause seizures, cardiac arrhythmias, or death). Kidney damage Nausea, vomiting, headache Blood pressure drops Injection site irritation 🚫 Not Approved For: “Detox” or anti-aging therapy Cardiovascular or atherosclerosis treatment (not FDA-approved and unsafe) ✅ Summary: Condition Use of Disodium EDTA Severe Hypercalcemia ✅ Yes Digoxin (digitalis) toxicity ⚠️ Rare, supportive Lead or heavy metal poisoning ❌ NO (use CaNa₂EDTA) Detox / cosmetic use ❌ Not approved/safe

LIVOMAG Injection (Magnesium Chloride Injection) is used to treat or prevent magnesium deficiency and manage various medical conditions that require magnesium supplementation. 🔹 Common Uses of LIVOMAG Injection: Magnesium Deficiency (Hypomagnesemia) Used when blood magnesium levels are low, especially in hospitalized or critically ill patients. Eclampsia & Pre-eclampsia (in pregnancy) Acts as a central nervous system depressant to prevent or treat seizures in pregnant women with eclampsia. Cardiac Arrhythmias Especially helpful in treating torsades de pointes, a specific type of irregular heartbeat. Severe Asthma (Adjunct therapy) IV magnesium can help relax bronchial muscles during acute asthma attacks when other treatments fail. Neuromuscular Function Support Used in cases of muscle cramps, spasms, or twitching due to low magnesium. Electrolyte Imbalance Correction Often part of treatment in critical care, especially in ICU settings when patients have multiple electrolyte imbalances. 💉 Dosage & Administration: Administered intravenously (IV) or intramuscularly (IM) depending on the clinical situation. Doses vary based on severity and condition being treated. ⚠️ Precautions & Side Effects: Too much magnesium can lead to low blood pressure, respiratory depression, or irregular heartbeat. Caution in patients with kidney disease, as magnesium is excreted by the kidneys. Monitor serum magnesium levels during treatment.

Research has shown that nutritional modifications can slow the progression of cardiac disease and improve quality of life of companion animals. Strongbeat is a unique formula that contains amino acids, vitamins, minerals and anti-oxidants that provide energy & strengthen heart muscle function in pets. Strongbeat can be used in dogs and cats with pre-existing suboptimal cardiovascular functions, in breeds that are predisposed to cardiovascular stress and to support the heart in geriatric or older patients.

Timipar (Timolol Maleate 0.5%) Ophthalmic Solution is a prescription eye drop used to manage elevated intraocular pressure (IOP) in conditions such as open-angle glaucoma and ocular hypertension. By reducing the production of fluid within the eye, it helps lower IOP, thereby reducing the risk of optic nerve damage and potential vision loss. ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common form of glaucoma where the drainage angle in the eye remains open, but the trabecular meshwork is partially blocked, leading to increased IOP. • Ocular Hypertension: A condition characterized by higher-than-normal IOP without any signs of glaucoma damage. ________________________________________ 💊 Dosage and Administration • Typical Dosage: Instill one drop of the 0.5% solution into the affected eye(s) twice daily. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. o After instilling the drop, gently press the corner of your eye (near the nose) for 1–2 minutes to prevent the medication from draining out. ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Bronchial asthma or a history of bronchial asthma. o Severe chronic obstructive pulmonary disease (COPD). o Sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock. • Cautions: o Use with caution in patients with a history of heart disease, diabetes, or thyroid disorders, as beta-blockers can mask symptoms of hypoglycemia and hyperthyroidism. o Monitor for potential additive effects when used with other systemic beta-blockers. ________________________________________ 🧪 Mechanism of Action Timolol is a non-selective beta-adrenergic antagonist (beta-blocker) that reduces aqueous humor production in the eye, leading to a decrease in IOP. Its onset of action is typically within 20 minutes, with effects lasting up to 24 hours.

Timipar (Timolol Maleate 0.25%) eye drops are a prescription medication primarily used to manage elevated intraocular pressure (IOP) associated with conditions like open-angle glaucoma and ocular hypertension. By reducing the production of aqueous humor, the fluid inside the eye, Timolol helps lower IOP, thereby reducing the risk of optic nerve damage and potential vision loss . ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common type of glaucoma where the drainage angle in the eye remains open, but the trabecular meshwork is partially blocked, leading to increased IOP. • Ocular Hypertension: A condition characterized by higher-than-normal IOP without any signs of glaucoma damage. ________________________________________ 💊 Dosage and Administration • Typical Dosage: Instill one drop of the 0.25% solution into the affected eye(s) once or twice daily, as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them . ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Bronchial asthma or a history of bronchial asthma. o Severe chronic obstructive pulmonary disease (COPD). • Sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock . • Cautions: o Use with caution in patients with a history of heart disease, diabetes, or thyroid disorders, as beta-blockers can mask symptoms of hypoglycemia and hyperthyroidism. o Monitor for potential additive effects when used with other systemic beta-blockers . ________________________________________ 🧪 Mechanism of Action Timolol is a non-selective beta-adrenergic antagonist (beta-blocker) that reduces aqueous humor production in the eye, leading to a decrease in IOP. Its onset of action is typically within 20 minutes, with effects lasting up to 24 hours .