Combinib 250mg Tablet is used in the treatment of breast cancer. It works by stopping or slowing down the growth of cancer cells. It is either used alone or in combination with some other medicine to cure advanced-stage breast cancer. Combinib 250mg Tablet should be taken on an empty stomach or an hour before or 2 hours after a meal. The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine. Inform your doctor if you notice a severe headache, confusion, problems with your eyesight, nausea, or vomiting. Your doctor may check your liver function before, during, and after treatment with this medicine. Before taking Combinib 250mg Tablet, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details. Uses of Combinib Tablet Pancreatic cancer Small cell lung cancer Liver cancer Kidney cancer Thyroid cancer Blood cancer (Chronic myeloid leukaemia) Gastrointestinal stromal tumour Cancer of colon and rectum Non-small cell lung cancer Soft tissue sarcoma Chronic idiopathic myelofibrosis Breast cancer Side effects of Combinib Tablet Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Combinib Abdominal pain Back pain Breathing problems Constipation Cough Diarrhea Fatigue Headache Hot flashes Increased bilirubin in the blood Insomnia (difficulty in sleeping) Joint pain Liver damage Loss of appetite Mucosal inflammation Nausea Pain in extremities Rash Stomatitis (Inflammation of the mouth) Vomiting Weakness Weight gain How to use Combinib Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combinib 250mg Tablet is to be taken empty stomach. How Combinib Tablet works Combinib 250mg Tablet is an anti-cancer medication. It works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which are responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways. Safety advice warnings Alcohol CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Combinib 250mg Tablet. Please consult your doctor. warnings Pregnancy CONSULT YOUR DOCTOR Combinib 250mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor. warnings Breast feeding UNSAFE Combinib 250mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby. warnings Driving UNSAFE Combinib 250mg Tablet may cause side effects which could affect your ability to drive. warnings Kidney CAUTION Combinib 250mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor. Limited information is available on the use of Combinib 250mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. warnings Liver CAUTION Combinib 250mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Combinib 250mg Tablet may be needed. Please consult your doctor. Limited information is available on the use of this medicine in patients with the severe liver disease.

INTRODUCTION ABOUT I DOX 20MG INJECTION I DOX 20MG INJECTION contains Doxorubicin which belongs to the group of medicines called Anti-cancer agents. It is used to manage certain types of cancers. It is used either alone or along with other anti-cancer medicines. Cancer is a disease in which some of the cells of the body grow uncontrollably and spread to other parts of the body. Before receiving I DOX 20MG INJECTION, inform your doctor if you have or ever had heart disease, either before or during radiotherapy, had or having live or live-attenuated vaccinations, are currently taking or have recently taken Trastuzumab (used in the management of certain cancers). There are no adequate and well-controlled studies in pregnant women. Consult your doctor during breast-feeding before starting management with this medicine as it may pass through the breast milk and possibly harm your child. Consult your doctor for advice before receiving the medicine. The most common side effects of I DOX 20MG INJECTION are infection, lack of appetite, inflammation in the mouth, diarrhea, nausea, vomiting, reddening, swelling, pain, numbness and tingling in the palms and feet may also occur whilst being managed with this medicine. Hair loss is very common and may be quite severe, beard growth may stop in men, fever, feeling weak, chills, abnormal ECG (electrical trace of the heart) results, raised levels of liver enzymes (as detected by a blood test) can determine if the medicine is having an abnormal effect on your liver, weight increased in patients with early breast cancer. USES OF I DOX 20MG INJECTION Used to manage certain types of cancer HOW I DOX 20MG INJECTION WORKS I DOX 20MG INJECTION works by suppressing the activity of an enzyme (topoisomerase II) involved in the DNA multiplication of the cancer cells. On the other hand, this also forms harmful chemicals (free radicals) which cause damage to the DNA. This slowdown the growth of cancer cells and eventually works against them. DIRECTIONS FOR USE I DOX 20MG INJECTION will be administered intravenously (IV) into the vein by your doctor or nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition. SIDE EFFECTS OF I DOX 20MG INJECTION COMMON infection lack of appetite inflammation in the mouth diarrhea nausea, vomiting hair loss beard growth may stop (in men) redness, swelling and blistering on the palms of the hands and soles of the feet (palmar-plantar erythrodysesthesia syndrome) chills weakness abnormal ECG raised levels of liver enzymes weight increased in patients with early breast cancer blood poisoning heart problems conjunctivitis (red watery eyes) lacrimation, excess tear production shortness of breath and swelling of the ankles increased heart rate inflammation of the throat and gullet stomach pain skin rashes, redness, hives nails and skin may appear darker than usual injection site reactions such as redness and swelling neutropenia thrombocytopenia malaise/asthenia infertility (in women) absence or decrease in sperm count (in men) UNCOMMON embolism (blockage in the bloodstream) RARE Stop receiving I DOX 20MG INJECTION and contact your doctor immediately if you experience any of the following side effects: dizzy, feverish, short of breath with a tight chest or throat or having an itchy rash anemia (low red blood cell count) decrease in white blood cell counts which in turn causes an increase in infections and a raised temperature (fever) platelets can be affected which could make a bruise or bleed more easily decreased activity in bone marrow reddening of urine dehydration inflammation of veins irritation or bleeding in the intestines inflammation of the lining of the stomach heartburn soreness or ulcers in the mouth

Winolap DS 2.5 ml Eye Drops Active Ingredient: Olopatadine Hydrochloride 0.2% Manufacturer: Sun Pharmaceutical Industries Ltd. Uses Winolap DS Eye Drops are primarily used to: Treat Allergic Conjunctivitis: Relieves symptoms of eye redness, itching, and watering due to allergens like pollen, dust, or pet dander. Provide Relief: Reduces eye irritation and inflammation caused by allergies. How It Works Olopatadine is an antihistamine that blocks histamine release from mast cells. This helps reduce allergic symptoms in the eyes such as itching, redness, and swelling. How to Use Wash your hands thoroughly before use. Tilt your head back and gently pull down the lower eyelid. Instill 1 drop into the affected eye(s) as directed (typically twice daily). Close your eye and gently press the inner corner of the eye near the nose for about 1 minute to help keep the drops in the eye. Recap the bottle and wash your hands again. Common Side Effects Mild burning or stinging sensation after application. Temporary blurred vision. Mild irritation or redness of the eye. Precautions Allergies: Avoid use if allergic to Olopatadine or any other ingredients in the drops. Contact Lenses: Remove contact lenses before using the drops and wait 15 minutes before reinserting them. Pregnancy & Breastfeeding: Consult your doctor before using this product. Children: Not recommended for children under 3 years old. Driving: May cause blurred vision temporarily, so avoid driving until vision is clear.

Tobi-D (Tobramycin with Dexamethasone) Eye Drops is a prescription ophthalmic solution combining an antibiotic and a corticosteroid to treat specific bacterial eye infections accompanied by inflammation. ________________________________________ ✅ Primary Uses Tobi-D is primarily used for: • Bacterial Conjunctivitis: Infection of the conjunctiva (the membrane covering the white part of the eye and the inner surface of the eyelids). • Keratitis: Infection of the cornea. • Post-surgical Infections: Prophylactic treatment or management of infections following eye surgeries. It addresses both the infection and the inflammation associated with these conditions. ________________________________________ 💊 Dosage and Administration • Standard Dosage: Instill 1–2 drops into the affected eye(s) every 4–6 hours, or as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them. ________________________________________ ⚠️ Contraindications and Cautions • Contraindications: o Hypersensitivity to tobramycin, dexamethasone, or any component of the formulation. o Active viral infections of the eye, such as herpes simplex keratitis. o Untreated fungal or mycobacterial infections of the eye. • Cautions: o Use with caution in patients with a history of glaucoma, as corticosteroids can increase intraocular pressure. o Prolonged use may lead to cataract formation or secondary ocular infections. o Consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. ________________________________________ 🧪 Mechanism of Action • Tobramycin: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, leading to bacterial cell death. • Dexamethasone: A corticosteroid that reduces inflammation by inhibiting the release of inflammatory mediators. Together, these components address both the infection and the inflammation associated with certain eye conditions.

Timipar (Timolol Maleate 0.25%) eye drops are a prescription medication primarily used to manage elevated intraocular pressure (IOP) associated with conditions like open-angle glaucoma and ocular hypertension. By reducing the production of aqueous humor, the fluid inside the eye, Timolol helps lower IOP, thereby reducing the risk of optic nerve damage and potential vision loss . ________________________________________ ✅ Primary Uses • Open-Angle Glaucoma: A common type of glaucoma where the drainage angle in the eye remains open, but the trabecular meshwork is partially blocked, leading to increased IOP. • Ocular Hypertension: A condition characterized by higher-than-normal IOP without any signs of glaucoma damage. ________________________________________ 💊 Dosage and Administration • Typical Dosage: Instill one drop of the 0.25% solution into the affected eye(s) once or twice daily, as directed by your healthcare provider. • Application Tips: o Wash your hands before use. o Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. o If you wear contact lenses, remove them before applying the drops and wait at least 15 minutes before reinserting them . ________________________________________ ⚠️ Precautions and Contraindications • Contraindications: o Hypersensitivity to any component of the formulation. o Bronchial asthma or a history of bronchial asthma. o Severe chronic obstructive pulmonary disease (COPD). • Sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock . • Cautions: o Use with caution in patients with a history of heart disease, diabetes, or thyroid disorders, as beta-blockers can mask symptoms of hypoglycemia and hyperthyroidism. o Monitor for potential additive effects when used with other systemic beta-blockers . ________________________________________ 🧪 Mechanism of Action Timolol is a non-selective beta-adrenergic antagonist (beta-blocker) that reduces aqueous humor production in the eye, leading to a decrease in IOP. Its onset of action is typically within 20 minutes, with effects lasting up to 24 hours .

HYLA FRESH (Sodium Hyaluronate) Eye Drops are designed to provide relief for dry, tired, or irritated eyes. These drops combine sodium hyaluronate with Euphrasia officinalis (Eyebright) extract, offering a soothing effect for various eye discomforts. ________________________________________ 🔍 Uses • Dry Eye Relief: HYLA FRESH helps alleviate dryness caused by environmental factors such as air conditioning, heating, or prolonged screen time. • Contact Lens Comfort: Provides lubrication to reduce discomfort associated with contact lens wear. Environmental Irritation: Soothes eyes irritated by wind, dust, or pollen exposure. Post-Surgical Care: Assists in the healing process following eye surgeries by maintaining moisture and reducing irritation. ________________________________________ 💧 Dosage and Administration • General Dosage: Instill 1–2 drops into the affected eye(s) as needed. • Application Method: 1. Wash your hands thoroughly. 2. Tilt your head back and gently pull down the lower eyelid to create a small pocket. 3. Place the dropper tip near the eye without touching it. 4. Squeeze the bottle to release the prescribed number of drops. 5. Close your eye and blink several times to spread the solution evenly. ________________________________________ ⚠️ Side Effects and Precautions • Common Side Effects: o Temporary blurred vision. o Mild burning or stinging sensation upon application. • Serious Side Effects: o Persistent eye discomfort or redness. o Signs of an allergic reaction (rash, itching, swelling). • Precautions: o Consult a healthcare provider before use if you have any known allergies to the ingredients. o Avoid touching the dropper tip to any surface to prevent contamination. o If you wear contact lenses, remove them before applying the drops unless otherwise directed by your doctor.

Blink Plus (Polyethylene & Propylene Glycol) Ophthalmic Solution is an over-the-counter eye drop formulation designed to provide relief for dry or irritated eyes. Here's an overview of its uses, dosage, side effects, and safety considerations: ________________________________________ 🔍 Uses Blink Plus combines two lubricating agents: • Polyethylene Glycol 400 (0.4%): Acts as a lubricant to relieve dryness and irritation by providing moisture to the eyes. It creates a protective layer on the eye's surface, reducing discomfort and enhancing tear film stability. Propylene Glycol (0.3%): Functions as a solvent and humectant, helping to dissolve and stabilize the active ingredients while attracting moisture to the eye, aiding in hydration and alleviating dryness. This combination is used to treat dry eye symptoms caused by environmental factors such as wind, sun, air conditioning, or prolonged screen time. ________________________________________ 💧 Dosage and Administration • General Dosage: Instill one or two drops into the affected eye(s) as needed. • Application Method: 1. Wash your hands thoroughly before use. 2. Tilt your head back slightly and pull down the lower eyelid to form a pouch. 3. Hold the dropper above the eye and instill the prescribed number of drops. 4. Close the eye gently and apply gentle pressure to the inner corner of the eye for 1 to 2 minutes to prevent the medication from draining away. 5. Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. ________________________________________ ⚠️ Safety and Side Effects • Common Side Effects: o Temporary blurred vision. o Mild burning or stinging sensation upon application. o Eye discomfort or irritation. • Redness or watering of the eyes. • Serious Side Effects: o Persistent eye pain or swelling. o Allergic reactions such as rash, itching, swelling, or severe dizziness. • Precautions: o Consult your doctor if you are pregnant or breastfeeding, as the safety of Blink Plus during these periods is not well-established. o Use with caution if you have a history of eye infections or other eye conditions. o Avoid driving or operating machinery if you experience blurred vision or visual disturbances.

Paricar (Pilocarpine Nitrate 2% Eye Drops) is a miotic ophthalmic solution primarily used to manage certain eye conditions by reducing intraocular pressure. ________________________________________ 🔍 Uses 1. Treatment of Glaucoma and Ocular Hypertension Pilocarpine Nitrate 2% is employed to lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It facilitates the drainage of aqueous humor from the eye, thereby reducing IOP and helping prevent vision loss and nerve damage. 2. Management of Acute Angle-Closure Glaucoma In acute angle-closure glaucoma, Pilocarpine Nitrate 2% may be used to constrict the pupil, facilitating the opening of the angle between the iris and cornea, which helps in reducing IOP. 3. Induction of Miosis Pilocarpine Nitrate 2% is utilized to induce miosis (pupil constriction) during certain eye surgeries or to reverse the effects of drugs used to dilate the pupil during eye examinations. ________________________________________ 💧 Dosage and Administration • General Dosage: Instill one drop into the affected eye(s) 1 to 4 times daily, as directed by your healthcare provider. • Application Method: 1. Wash your hands thoroughly before use. 2. Tilt your head back slightly and pull down the lower eyelid to form a pouch. 3. Hold the dropper above the eye and instill the prescribed number of drops. 4. Close the eye gently and apply gentle pressure to the inner corner of the eye for 1 to 2 minutes to prevent the medication from draining away. 5. Avoid touching the dropper tip to any surface, including the eye, to prevent contamination. ________________________________________ ⚠️ Safety and Side Effects • Common Side Effects: o Temporary eye discomfort, such as stinging or burning sensations. o Blurred vision. o Headache. • Visual disturbances. • Serious Side Effects: o Although rare, systemic absorption may lead to increased blood pressure, headache, or dizziness. • Precautions: o Consult your doctor if you are pregnant or breastfeeding, as the safety of Pilocarpine Nitrate 2% during these periods is not well-established. o Use with caution if you have a history of retinal diseases or other eye conditions. o Avoid driving or operating machinery if you experience blurred vision or visual disturbances.

Biopat Olopatadine Hydrochloride 0.2% Ophthalmic Solution is an antihistamine eye drop used to treat allergic conjunctivitis, providing relief from symptoms such as itchy, red, or watery eyes. ________________________________________ 🔍 Uses This eye drop is specifically indicated for the temporary relief of ocular itching associated with allergic conjunctivitis. Common allergens include pollen, ragweed, grass, and animal hair and dander . ________________________________________ 💧 How It Works Olopatadine functions as both an antihistamine and a mast cell stabilizer. It blocks histamine release and prevents the activation of mast cells, which are involved in allergic reactions, thereby reducing eye inflammation and irritation . ⚠️ Warnings and Precautions • For external use only. • Do not use if the solution changes color or becomes cloudy. • Avoid use if sensitive to any ingredient in the product. • Not intended for treating contact lens-related irritation. • Remove contact lenses before use and wait at least 10 minutes before reinserting them .